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Author Details

Jill M Spoerke
1996
32
24
PMIDPaper TitleJournal TitlePublished Year
36401732The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HRâ¿¿+â¿¿/HER2â¿¿-) advanced/metastatic breast cancer.Breast Cancer Res Treat2023
36530475, a enhancer mutation, is an allele of .2022
32247862Genomic Analysis of Circulating Tumor Cells at the Single-Cell Level.J Mol Diagn2020
30617129Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in a Squamous Lung Cancer Clinical Cohort.Clinical Cancer Research2019
30171174Genomic Alterations Associated with Recurrence and TNBC Subtype in High-Risk Early Breast Cancers.Molecular Cancer Research2019
30185228A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer.Breast Cancer Res2018
29936259Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA.J Mol Diagn2018
28798270A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors.Oncologist2017
27603005A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study).Cancer2016
28721382The molecular landscape of high-risk early breast cancer: comprehensive biomarker analysis of a phase III adjuvant population.npj Breast Cancer2016
26759240Activating Mutations in PIK3CB Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β.Cancer Research2016
26787751Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors.Clin Cancer Res2016
27174596Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant.Nature Communications2016
26951309Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma.Journal of Clinical Oncology2016
25370471First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors.Clin Cancer Res2015
24520381Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers.PLoS ONE2014
25338319Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples.Breast Cancer Res Treat2014
24366379Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer.Oncogenesis2013
23284662Mutation scanning using MUT-MAP, a high-throughput, microfluidic chip-based, multi-analyte panel.PLoS ONE2012
22402123ERK inhibition overcomes acquired resistance to MEK inhibitors.Molecular Cancer Therapeutics2012
23136191Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models.Clinical Cancer Research2012
21868360miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer.Sci Signal2011
21673316TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer.Sci Signal2011
21998291GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.Molecular Cancer Therapeutics2011
20838621Molecular biomarker analyses using circulating tumor cells.PLoS One2010
19056674Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays.Molecular Cancer Therapeutics2008
17154430Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase.ChemMedChem2007
15208781A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.Am J Hum Genet2004
10704412EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans.Current Biology2000
10508845High-throughput isolation of Caenorhabditis elegans deletion mutants.Genome Res1999
28565720DIVERGENCE IN SYMBIOTIC COMPATIBILITY IN A LEGUME-BRADYRHIZOBIUM MUTUALISM.Evolution; international journal of organic evolution1996
28568881NONRANDOM GENOTYPIC ASSOCIATIONS IN A LEGUME-BRADYRHIZOBIUM MUTUALISM.Evolution; international journal of organic evolution1996
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