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Author Details

Alpha A Fowler
Virginia Commonwealth University
1978
127
41
PMIDPaper TitleJournal TitlePublished Year
36297099Biological Effects of Intravenous Vitamin C on Neutrophil Extracellular Traps and the Endothelial Glycocalyx in Patients with Sepsis-Induced ARDS.Nutrients2022
36057279Opportunities for improved clinical trial designs in acute respiratory distress syndrome.Lancet Respir Med2022
34684565Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis.Nutrients2021
33620405Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.JAMA2021
32317004In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol.Trials2020
32013700Vitamin C Intravenous Treatment In the Setting of Atrial Fibrillation Ablation: Results From the Randomized, Double-Blinded, Placebo-Controlled CITRIS-AF Pilot Study.J Am Heart Assoc2020
32096845Vitamin C for Sepsis and Acute Respiratory Failure-Reply.JAMA2020
31978969The Emerging Role of Vitamin C as a Treatment for Sepsis.Nutrients2020
31140644Hematopoietic stem cell mobilization following PD-1 blockade: Cytokine release syndrome after transplantation managed with ascorbic acid.Eur J Haematol2019
31801567Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.Trials2019
31267566Reduced plasma ascorbic acid levels in recipients of myeloablative conditioning and hematopoietic cell transplantation.Eur J Haematol2019
31322812Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment.J Thromb Haemost2019
31573637Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial.JAMA2019
31343474Supply Chain Delays in Antimicrobial Administration After the Initial Clinician Order and Mortality in Patients With Sepsis.Crit Care Med2019
30953543The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.Trials2019
29538225Interventional vitamin C: A strategy for attenuation of coagulopathy and inflammation in a swine multiple injuries model.J Trauma Acute Care Surg2018
28704937Attenuation of Red Blood Cell Storage Lesions with Vitamin C.Antioxidants (Basel)2017
28224112Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome.World J Crit Care Med2017
28224106Impact of high dose vitamin C on platelet function.World J Crit Care Med2017
27188767Conservative fluid management prevents age-associated ventilator induced mortality.Exp Gerontol2016
26290474Vitamin C promotes wound healing through novel pleiotropic mechanisms.Int Wound J2016
27891260Intravenous Vitamin C Administered as Adjunctive Therapy for Recurrent Acute Respiratory Distress Syndrome.Case Rep Crit Care2016
25286290Lung cancer screening with low-dose computed tomography: an analysis of the MEDCAC decision.J Thorac Imaging2015
26612352Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?Crit Care2015
23917525Attenuation of sepsis-induced organ injury in mice by vitamin C.JPEN J Parenter Enteral Nutr2014
25294953Resolution of sterile inflammation: role for vitamin C.Mediators Inflamm2014
24484547Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis.J Transl Med2014
23576683Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase.J Lipid Res2013
23939536Vitamin C: a novel regulator of neutrophil extracellular trap formation.Nutrients2013
22523283Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid.Am J Physiol Lung Cell Mol Physiol2012
22830464Antibiotic prevention of acute exacerbations of COPD.N Engl J Med2012
21358394Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury.Crit Care Med2011
19524066Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes.Vascul Pharmacol2009
18287886Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury.J Cardiovasc Pharmacol2008
17336340Hypoxia inducible factor-1 modulates hemin-induced IL-8 secretion in microvascular endothelium.Microvasc Res2007
17545479Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium.Am J Physiol Heart Circ Physiol2007
17577107Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure.J Cardiovasc Pharmacol2007
16306444Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury.Circ Res2006
17108344Clinical practice. Acute bronchitis.N Engl J Med2006
15805230HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation.Am J Physiol Heart Circ Physiol2005
16234848Hypoxia inducible factor-1: regulation by nitric oxide in posthypoxic microvascular endothelium.Biochem Cell Biol2005
14656710Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites.Am J Physiol Gastrointest Liver Physiol2004
12765172'My doctor said I had an abnormal chest X-ray'...Respiration2003
12914933Regulation of hypoxia inducible factor-1 by nitric oxide in contrast to hypoxia in microvascular endothelium.FEBS Lett2003
14613754Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn's disease.Clin Nutr2003
12008118Reoxygenating microvascular endothelium exhibits temporal dissociation of NF-kappaB and AP-1 activation.Free Radic Biol Med2002
12361806Atypical mechanism of NF-kappaB activation during reoxygenation stress in microvascular endothelium: a role for tyrosine kinases.Free Radic Biol Med2002
11464091Obstructive granulomatous bronchiolitis due to Mycobacterium avium complex in an immunocompetent man.Respiration2001
11399048Nitric oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation.Exp Cell Res2001
11440632Redox imbalance in Crohn's disease intestinal smooth muscle cells causes NF-kappaB-mediated spontaneous interleukin-8 secretion.J Interferon Cytokine Res2001
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Collaborators

Emory University
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Virginia Commonwealth University
Co-authored papers 6
Virginia Commonwealth University
Co-authored papers 6
Virginia Commonwealth University
Co-authored papers 6
Emory University School of Medicine
Co-authored papers 6
Johns Hopkins University
Co-authored papers 4
Thomas Jefferson University
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Johns Hopkins University
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Berry Consultants LLC
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Johns Hopkins School of Medicine
Co-authored papers 4
Johns Hopkins University School of Medicine
Co-authored papers 4
Vanderbilt University Medical Center
Co-authored papers 4
9Stanford University
Co-authored papers 4
Vanderbilt University
Co-authored papers 4
Emory University School of Medicine
Co-authored papers 4
Duke University
Co-authored papers 4
University of Wisconsin School of Medicine and Public Health
Co-authored papers 4
Eastern Virginia Medical School and Sentara Healthcare
Co-authored papers 4
Vanderbilt University Medical Center
Co-authored papers 3
Vanderbilt University School of Medicine
Co-authored papers 3
Vanderbilt University Medical Center
Co-authored papers 3
Molecular and Clinical Nutrition Section
Co-authored papers 2
Medical College of Wisconsin
Co-authored papers 2
Cleveland Clinic
Co-authored papers 1
Emory University
Co-authored papers 1
Johns Hopkins University School of Medicine
Co-authored papers 1
Emory University
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INSERM UMR-S , Universite de Paris Cite
Co-authored papers 1