Author details

Full Name

Sarel J Fleishman

Affiliation

ORCID

Career Start Year

2002

Papers

110

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36689349	Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions.		2023
37550425	Computational optimization of antibody humanness and stability by systematic energy-based ranking.		2023
37087500	Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases.		2023
37210560	Designed active-site library reveals thousands of functional GFP variants.		2023
37460146	The C-terminal tail of CSNAP attenuates the CSN complex.		2023
36881618	Computational design of BclxL inhibitors that target transmembrane domain interactions.		2023
37131620	Evolutionary paths that link orthogonal pairs of binding proteins.		2023
36634164	Combinatorial assembly and design of enzymes.		2023
36808692	Design of a stable human acid-Î²-glucosidase: towards improved Gaucher disease therapy and mutation classification.	FEBS J	2023
37385581	Stable Mammalian Serum Albumins Designed for Bacterial Expression.	J Mol Biol	2023
37253751	Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family.		2023
35323195	Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope.	Antibodies	2022
36366766	Designed High-Redox Potential Laccases Exhibit High Functional Diversity.	ACS Catalysis	2022
36040259	Assessing and enhancing foldability in designed proteins.	Protein Science	2022
35386102	Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin.	Computational and Structural Biotechnology Journal	2022
35506657	De novo-designed transmembrane domains tune engineered receptor functions.	Elife	2022
35641498	Computationally designed hyperactive Cas9 enzymes.	Nature Communications	2022
36320402	Protein quaternary structures in solution are a mixture of multiple forms.	Chem Sci	2022
36188189	Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern.	iScience	2022
37850148	What Have We Learned from Design of Function in Large Proteins?		2022
35173332	Structure and receptor recognition by the Lassa virus spike complex.	Nature	2022
35179866	Stable and Functionally Diverse Versatile Peroxidases Designed Directly from Sequences.	Journal of the American Chemical Society	2022
35102291	Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.	Nat Biotechnol	2022
35325236	Stabilization of the SARS-CoV-2 receptor binding domain by protein core redesign and deep mutational scanning.	Protein Engineering, Design and Selection	2022
34845448	Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning.		2021
33901536	Extending the New Generation of Structure Predictors to Account for Dynamics and Allostery.	Journal of Molecular Biology	2021
33781758	Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.	J Mol Biol	2021
34211966	Computational Enzyme Engineering Pipelines for Optimized Production of Renewable Chemicals.	Frontiers in Bioengineering and Biotechnology	2021
34337607	Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction.	JACS Au	2021
34310051	Direct-MS analysis of antibody-antigen complexes.	Proteomics	2021
33040418	The AbDesign computational pipeline for modular backbone assembly and design of binders and enzymes.	Protein Science	2021
33367682	PROSS 2: a new server for the design of stable and highly expressed protein variants.		2021
34464610	The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against viral variants.	Cell Reports	2021
34783546	A Rationally and Computationally Designed Fluorescent Biosensor for d-Serine.	ACS Sensors	2021
31325330	Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5.	Proteins: Structure, Function and Bioinformatics	2020
33688632	One-step sequence and structure-guided optimization of HIV-1 envelope gp140.	Curr Res Struct Biol	2020
33085658	Correction: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.	PLoS Comput Biol	2020
32505941	Practically useful protein-design methods combining phylogenetic and atomistic calculations.	Current Opinion in Structural Biology	2020
31442220	Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.	PLoS Comput Biol	2019
30951584	AbPredict 2: a server for accurate and unstrained structure prediction of antibody variable domains.	Bioinformatics	2019
31461441	A lipophilicity-based energy function for membrane-protein modelling and design.	PLoS Computational Biology	2019
29677494	Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.	Mol Cell	2018
30459276	Design and in vitro realization of carbon-conserving photorespiration.	Proceedings of the National Academy of Sciences of the United States of America	2018
30270109	Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.	Mol Cell	2018
30018351	A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen.	Scientific Reports	2018
30018322	Highly active enzymes by automated combinatorial backbone assembly and sequence design.	Nat Commun	2018
30106564	Estimating Interprotein Pairwise Interaction Energies in Cell Lysates from a Single Native Mass Spectrum.	Analytical Chemistry	2018
30538236	Ultrahigh specificity in a network of computationally designed protein-interaction pairs.	Nat Commun	2018
30534605	Rapid characterization of secreted recombinant proteins by native mass spectrometry.	Commun Biol	2018
30088929	Manipulating the Folding Landscape of a Multidomain Protein.	J Phys Chem B	2018