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| 36736152 | Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore. | Eur J Med Chem | 2023 |
| 37489084 | Colorectal Cancer Organoid-Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses. | Cancer Discov | 2023 |
| 37558942 | Characterization of Cellular Viability Using Label-Free Brightfield Live-Cell Imaging. | Methods Mol Biol | 2023 |
| 37558941 | Annotation of the Effect of Chemogenomic Compounds on Cell Health Using High-Content Microscopy in Live-Cell Mode. | Methods Mol Biol | 2023 |
| 37558940 | Quality Control of Chemogenomic Library Using LC-MS. | Methods Mol Biol | 2023 |
| 37487467 | Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B. | J Med Chem | 2023 |
| 37857821 | Structure of LRRK1 and mechanisms of autoinhibition and activation. | Nat Struct Mol Biol | 2023 |
| 37800327 | Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence. | Circ Res | 2023 |
| 37797617 | A machine learning and live-cell imaging tool kit uncovers small molecules induced phospholipidosis. | Cell Chem Biol | 2023 |
| 38067641 | Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3<i>H</i>)-Ones with Antiproliferative Activities. | Molecules | 2023 |
| 38009092 | SGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4. | Curr Res Chem Biol | 2023 |
| 37845552 | Improving data quality in chemical biology. | Nat Chem Biol | 2023 |
| 38051674 | Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate. | J Med Chem | 2023 |
| 38047771 | Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting. | Elife | 2023 |
| 37828008 | DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. | Cell Death Dis | 2023 |
| 37495567 | 5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling. | Cell Death Discov | 2023 |
| 37354907 | Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization. | Cell Chem Biol | 2023 |
| 37253421 | Structural insights into a regulatory mechanism of FIR RRM1-FUSE interaction. | Open Biol | 2023 |
| 37385602 | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation. | J Am Chem Soc | 2023 |
| 37312836 | Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. | ACS Med Chem Lett | 2023 |
| 36944371 | Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum. | ACS Chem Biol | 2023 |
| 37439113 | Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia. | Autophagy | 2023 |
| 37204207 | Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ. | J Med Chem | 2023 |
| 37360399 | Target 2035 - an update on private sector contributions. | RSC Med Chem | 2023 |
| 37296900 | Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability. | Cancers (Basel) | 2023 |
| 37094449 | Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. | Eur J Med Chem | 2023 |
| 36625768 | Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity. | Angew Chem Int Ed Engl | 2023 |
| 36516476 | MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. | J Med Chem | 2023 |
| 36780422 | Toward effective Atg8-based ATTECs: Approaches and perspectives. | J Cell Biochem | 2023 |
| 36878151 | Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor. | Eur J Med Chem | 2023 |
| 36580549 | Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction. | J Med Chem | 2023 |
| 36913879 | Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells. | Bioorg Chem | 2023 |
| 36873168 | Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators. | Acta Pharm Sin B | 2023 |
| 36711619 | Death by a Thousand Cuts â⿬" Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology. | bioRxiv | 2023 |
| 36709803 | Epigenetic modulation by targeting bromodomain containing protein 9 (BRD9): Its therapeutic potential and selective inhibition. | Int J Biol Macromol | 2023 |
| 34213342 | Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors. | J Med Chem | 2022 |
| 35608370 | Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-<i>a</i>]pyrimidine-Based Macrocycles. | J Med Chem | 2022 |
| 35462054 | BET bromodomain inhibitors. | Curr Opin Chem Biol | 2022 |
| 35721509 | A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins. | Front Cell Dev Biol | 2022 |
| 35525558 | Enabling pseudokinases as potential drug targets. | Methods Enzymol | 2022 |
| 35717504 | Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. | Cell Death Differ | 2022 |
| 35688808 | Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. | Nat Commun | 2022 |
| 35562082 | Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism. | Mol Metab | 2022 |
| 35447555 | Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity. | Eur J Med Chem | 2022 |
| 35353987 | Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes. | Mol Cell | 2022 |
| 36499165 | Discovery of 3-Amino-1<i>H</i>-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. | Int J Mol Sci | 2022 |
| 36104565 | CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1. | Nature | 2022 |
| 36040231 | PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. | Biochem J | 2022 |
| 36136092 | Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. | J Med Chem | 2022 |
| 36098557 | Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains. | ACS Chem Biol | 2022 |