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Author Details

Max A Horlbeck
Broad Institute of MIT and Harvard
2012
32
22
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37398210FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer.Res Sq2023
37205599FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer.bioRxiv2023
37034577Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements.bioRxiv2023
36282590GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.JCI Insight2022
36381608Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells.Cell Genom2022
33326085Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.Methods Mol Biol2021
34034859Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.Elife2021
33465779High-content imaging-based pooled CRISPR screens in mammalian cells.J Cell Biol2021
32619469Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.Mol Cell2020
31932729Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.Nat Biotechnol2020
30875366Cellular response to small molecules that selectively stall protein synthesis by the ribosome.PLoS Genet2019
31488582New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.J Cell Biol2019
31395745Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.Science2019
29091290Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.Hepatology2018
30148842A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure.PLoS Biol2018
30033366Mapping the Genetic Landscape of Human Cells.Cell2018
29731168Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.Cell2018
29359686Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.Elife2018
29745899Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.Elife2018
27980086CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.Science2017
28985505Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.Mol Cell2017
26971820CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.Cell Stem Cell2016
27984733A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.Cell2016
27661255Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.Elife2016
27325776Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.Proc Natl Acad Sci U S A2016
27018887Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification.Nat Chem Biol2016
26987018Nucleosomes impede Cas9 access to DNA in vivo and in vitro.Elife2016
27081004Single-cell analysis of long non-coding RNAs in the developing human neocortex.Genome Biol2016
26080438Next-generation libraries for robust RNA interference-based genome-wide screens.Proc Natl Acad Sci U S A2015
25307932Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.Cell2014
23394947A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.Cell2013
22300850ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p.Science2012
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Collaborators

Jonathan S Weissman
Whitehead Institute for Biomedical Research
Co-authored papers 24
Luke A Gilbert
Arc Institute
Co-authored papers 16
Martin Kampmann
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 10
Jacqueline E Villalta
University of California san francisco
Co-authored papers 7
Daniel A Lim
University of California san francisco
Co-authored papers 5
Siyuan John Liu
University of California San Francisco.
Co-authored papers 5
Michael C Bassik
Stanford University Medical Center
Co-authored papers 4
Trever G Bivona
University of California san francisco
Co-authored papers 3
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Center for Genomic Integrity, Institute for Basic Science
Co-authored papers 2
Lei S Qi
Stanford University
Co-authored papers 2
Mohammad A Mandegar
Gladstone Institute of Cardiovascular Disease
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Howard Y Chang
Center for Personal Dynamic Regulomes, Stanford University
Co-authored papers 2
Bruce R Conklin
Gladstone Institutes
Co-authored papers 2
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University of California san francisco
Co-authored papers 2
Carol A Gross
University of California san francisco
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University of California San Francisco
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Daniel He
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Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
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Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Christopher Ian Spencer
Gladstone Institute of Cardiovascular Disease
Co-authored papers 1
Po-Lin So
Gladstone Institutes
Co-authored papers 1
Luke M Judge
Gladstone Institutes
Co-authored papers 1
Shelley L Berger
Penn Epigenetics Institute, Perelman School of Medicine
Co-authored papers 1
Amy J Wagers
Joslin Diabetes Center
Co-authored papers 1
Annie Truong
Gladstone Institutes
Co-authored papers 1
Kristin Holmes
Gladstone Institute of Cardiovascular Disease
Co-authored papers 1
Eugenio Mattei
Co-authored papers 1
Yuichiro Miyaoka
Tokyo Metropolitan Institute of Medical Science, Japan Gladstone Institutes
Co-authored papers 1
Edward C Shin
University of California san francisco
Co-authored papers 1
S??ren P Sheikh
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