Author details

Full Name

Thomas R Ioerger

Affiliation

ORCID

Career Start Year

1990

Papers

160

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37577548	A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens.	bioRxiv	2024
33619059	Deletion of Rv2571c confers resistance to arylamide compounds in .	Antimicrobial Agents and Chemotherapy	2023
37764112	Functional Whole Genome Screen of Nutrient-Starved Identifies Genes Involved in Rifampin Tolerance.		2023
37802316	Mycobacterial RNase E cleaves with a distinct sequence preference and controls the degradation rates of most Mycolicibacterium smegmatis mRNAs.		2023
37090629	Functional whole genome screen of nutrient-starved <i>Mycobacterium tuberculosis</i> identifies genes involved in antibiotic tolerance.	bioRxiv	2023
37399390	Phase variation as a major mechanism of adaptation in complex.		2023
37318217	The Rip1 intramembrane protease contributes to iron and zinc homeostasis in <i>Mycobacterium tuberculosis</i>.	mSphere	2023
36603206	The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.		2023
36920927	A mutant fitness assay identifies bacterial interactions in a model ocean hot spot.		2023
33619062	Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant <i>Mycobacterium tuberculosis</i>.	Antimicrob Agents Chemother	2023
34709629	Analysis of Gene Essentiality from TnSeq Data Using Transit.	Methods in Molecular Biology	2022
35659317	Transposon mutagenesis in identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity.	eLife	2022
35380903	Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.	Proc Natl Acad Sci U S A	2022
35876578	Correction for Shelton et al., "Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis".	Antimicrobial Agents and Chemotherapy	2022
35430871	Multiplexed Strain Phenotyping Defines Consequences of Genetic Diversity in Mycobacterium tuberculosis for Infection and Vaccination Outcomes.	mSystems	2022
36325756	1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in .	ACS Infectious Diseases	2022
35136132	PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis.	Scientific Reports	2022
35015509	A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of .	ACS Infectious Diseases	2022
34362035	Characterization of Drug-Resistant Lipid-Dependent Differentially Detectable .	Journal of Clinical Medicine	2021
34278512	Correction to: Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria.	Applied Microbiology and Biotechnology	2021
34269789	Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity.	Journal of Experimental Medicine	2021
33765439	Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis.	Cell Chemical Biology	2021
33405882	Structure-Activity Relationships of Pyrazolo[1,5-]pyrimidin-7(4)-ones as Antitubercular Agents.	ACS Infectious Diseases	2021
34520959	6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis.	European Journal of Medicinal Chemistry	2021
34665010	Modeling Site-Specific Nucleotide Biases Affecting Himar1 Transposon Insertion Frequencies in TnSeq Data Sets.	mSystems	2021
34597304	An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence.	PLoS ONE	2021
32782426	Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.	Evolutionary Bioinformatics	2020
32069330	Comprehensive analysis of iron utilization by Mycobacterium tuberculosis.	PLoS Pathog	2020
32418125	Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria.	Applied Microbiology and Biotechnology	2020
32470286	Synthesis, Structure-Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity.	ACS Infectious Diseases	2020
33103423	Nature-Inspired (di)Azine-Bridged Bisindole Alkaloids with Potent Antibacterial and Efficacy against Methicillin-Resistant .	Journal of Medicinal Chemistry	2020
33361193	The conserved translation factor LepA is required for optimal synthesis of a porin family in Mycobacterium smegmatis.	J Bacteriol	2020
32753506	Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis.	mSystems	2020
32916109	Cell-Cycle-Associated Expression Patterns Predict Gene Function in Mycobacteria.	Current Biology	2020
33077652	Mutations in () as a Novel Determinant of Resistance to Pretomanid and Delamanid in Mycobacterium tuberculosis.	Antimicrobial Agents and Chemotherapy	2020
33019236	Reinforcement Learning using EEG signals for Therapeutic Use of Music in Emotion Management.	Annu Int Conf IEEE Eng Med Biol Soc	2020
33282750	Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against .	Frontiers in Cellular and Infection Microbiology	2020
31209015	3--Methyl-Alkylgallates Inhibit Fatty Acid Desaturation in Mycobacterium tuberculosis.	Antimicrobial Agents and Chemotherapy	2019
31620228	Novel Pyrazole-Containing Compounds Active against <i>Mycobacterium tuberculosis</i>.	ACS Med Chem Lett	2019
31822597	Global Assessment of Mycobacterium avium subsp. Genetic Requirement for Growth and Virulence.	mSystems	2019
31752678	Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.	BMC Bioinformatics	2019
32974504	Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in .		2019
30445130	A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex.	Microbes Infect	2019
30629068	Design criteria for minimalist mimics of protein-protein interface segments.	Organic and Biomolecular Chemistry	2019
30705156	Opposing reactions in coenzyme A metabolism sensitize <i>Mycobacterium tuberculosis</i> to enzyme inhibition.	Science	2019
31086182	GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions.	Nat Commun	2019
31217586	Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.	Nature	2019
31163081	Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.	PLoS Pathog	2019
31388080	Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.	Scientific Reports	2019
30847453	Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis.	Organic and Biomolecular Chemistry	2019