Author details

Full Name

Joseph R Dorkin

Affiliation

ORCID

Career Start Year

2008

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
32937374	Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing.	Science advances	2020
29499956	Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection InÂ Vivo with a loxP-Flanked tdTomato Reporter Mouse.	Molecular Therapy - Nucleic Acids	2018
28273716	Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy.	Nano Letters	2017
28681930	Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes.	Advanced Materials	2017
27921096	Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo.	Biomaterials Science	2016
26889757	Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery.	Advanced Materials	2016
26829318	Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.	Nat Biotechnol	2016
26727632	Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.	Nano Letters	2016
27356951	Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system.	Gene Therapy	2016
26469188	Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.	Nano Letters	2015
24969323	Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity.	Nature Communications	2014
24623658	Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.	Advanced healthcare materials	2014
25022906	Non-viral vectors for gene-based therapy.	Nature Reviews Genetics	2014
24516150	Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.	Proceedings of the National Academy of Sciences of the United States of America	2014
24150415	Delivery materials for siRNA therapeutics.	Nature Materials	2013
22770391	In vitro-in vivo translation of lipid nanoparticles for hepatocellular siRNA delivery.	ACS Nano	2012
20461061	Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.	Molecular Therapy	2010
20081866	Rational design of cationic lipids for siRNA delivery.	Nature Biotechnology	2010
20080679	Lipid-like materials for low-dose, in vivo gene silencing.	Proceedings of the National Academy of Sciences of the United States of America	2010
19259063	Development of lipidoid-siRNA formulations for systemic delivery to the liver.	Molecular Therapy	2009
18695239	Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.	Proceedings of the National Academy of Sciences of the United States of America	2008
18781145	Assessing siRNA pharmacodynamics in a luciferase-expressing mouse.	Molecular Therapy	2008
18438401	A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.	Nat Biotechnol	2008
18989463	Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection.	PLoS Pathogens	2008