Author details

Full Name

Heather E Wheeler

Affiliation

ORCID

Career Start Year

2009

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36798214	Multivariate adaptive shrinkage improves cross-population transcriptome prediction for transcriptome-wide association studies in underrepresented populations.	bioRxiv	2023
37869564	Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations.	HGG Adv	2023
37409955	Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial Cancers Implicate Plasma Protein Regulation in Cancer Susceptibility.	Cancer Epidemiol Biomarkers Prev	2023
36941441	Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.	Nat Genet	2023
35027082	Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries.	Genome Biol	2022
35385699	Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program.	Am J Hum Genet	2022
35858592	Genetic and environmental variation impact transferability of polygenic risk scores.	Cell Reports Medicine	2022
33937878	Transcriptome prediction performance across machine learning models and diverse ancestries.	Human Genetics and Genomics Advances	2021
33575800	Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populations.	Hum Mol Genet	2021
32998964	Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.	Clin Cancer Res	2020
33313492	Population-Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate.	iScience	2020
32986714	Multi-ethnic transcriptome-wide association study of prostate cancer.	PLoS ONE	2020
32964524	Fine-mapping and QTL tissue-sharing information improves the reliability of causal gene identification.	Genetic Epidemiology	2020
33072440	Comparing local ancestry inference models in populations of two- and three-way admixture.	PeerJ	2020
31296530	Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.	Clin Cancer Res	2019
31579629	Transcriptome association studies of neuropsychiatric traits in African Americans implicate in schizophrenia.	PeerJ	2019
30616504	Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila.	BMC Genomics	2019
29795408	Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity.	Pharmacogenomics J	2019
30668570	Integrating predicted transcriptome from multiple tissues improves association detection.	PLoS Genet	2019
31393916	Genetically regulated gene expression underlies lipid traits in Hispanic cohorts.	PLoS ONE	2019
29404214	Gene-based association study for lipid traits in diverse cohorts implicates and regulation in triglyceride levels.	PeerJ	2018
30061609	Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.	Nat Commun	2018
30096133	Genetic architecture of gene expression traits across diverse populations.	PLoS Genetics	2018
29739930	Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.	Nat Commun	2018
28039263	Variants in <i>WFS1</i> and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.	Clin Cancer Res	2017
28645005	Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy.	Stem Cell Res	2017
28335481	Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.	Int J Mol Sci	2017
28611204	Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.	Clin Cancer Res	2017
27835642	Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues.	PLoS Genet	2016
27143689	Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.	Clin Cancer Res	2016
27354478	Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer.	J Clin Oncol	2016
26258848	A gene-based association method for mapping traits using reference transcriptome data.	Nat Genet	2015
25710658	Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.	JAMA	2015
25689802	Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells.	PLoS One	2015
26015512	Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.	Clin Cancer Res	2015
24595012	Identification of genetic variants associated with capecitabine-induced hand-foot syndrome through integration of patient and cell line genomic analyses.	Pharmacogenet Genomics	2014
24799323	Poly-omic prediction of complex traits: OmicKriging.	Genet Epidemiol	2014
25119182	Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group.	Cancer Chemother Pharmacol	2014
21844884	Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.	Pharmacogenomics J	2013
24029420	Common variants in Mendelian kidney disease genes and their association with renal function.	J Am Soc Nephrol	2013
24367505	EPS8 inhibition increases cisplatin sensitivity in lung cancer cells.	PLoS One	2013
23183705	Cancer pharmacogenomics: strategies and challenges.	Nat Rev Genet	2013
23538338	Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients.	Blood	2013
23204130	Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.	Clin Cancer Res	2013
23720496	Genetic and epigenetic variants contributing to clofarabine cytotoxicity.	Hum Mol Genet	2013
22176622	Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation.	Pharmacogenomics	2012
22437668	Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel.	Pharmacogenet Genomics	2012
22479191	Genome-wide association and functional follow-up reveals new loci for kidney function.	PLoS Genet	2012
22962313	Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.	Hum Mol Genet	2012
22840197	Relating human genetic variation to variation in drug responses.	Trends Genet	2012