Author details

Full Name

Ophir Shalem

Affiliation

Perelman School of Medicine, University of Pennsylvania

ORCID

Career Start Year

2008

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
38077016	The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress.	bioRxiv	2024
36516294	Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins.	Brain	2023
37790450	Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics.	Res Sq	2023
37783943	A subpopulation of lipogenic brown adipocytes drives thermogenic memory.	Nat Metab	2023
37503056	Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics.	bioRxiv	2023
37503003	Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses.	bioRxiv	2023
37425875	High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs.	bioRxiv	2023
36404134	Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span.	Aging Cell	2023
35315913	Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.	Cancer Res	2022
34714674	Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.	Sci Adv	2021
32591764	Publisher Correction: Building an international consortium for tracking coronavirus health status.	Nat Med	2020
32001516	Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction.	Cancer Discov	2020
32577674	Population-scale Longitudinal Mapping of COVID-19 Symptoms, Behavior, and Testing Identifies Contributors to Continued Disease Spread in the United States.	medRxiv	2020
32848231	Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing.	Nat Hum Behav	2020
31239279	Efficient and flexible tagging of endogenous genes by homology-independent intron targeting.	Genome Res	2019
31761535	The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPR<sup>ER</sup>.	Cell	2019
29651054	Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.	Nat Protoc	2018
30297850	CRISPR mutagenesis screening of mice.	Nat Cell Biol	2018
28764860	CRISPRing the Regulatory Genome, the Challenge Ahead.	Trends Genet	2017
28241139	Transcription control by the ENL YEATS domain in acute leukaemia.	Nature	2017
28783722	Identification of essential genes for cancer immunotherapy.	Nature	2017
26917594	Hypoxia as a therapy for mitochondrial disease.	Science	2016
27708104	High-resolution interrogation of functional elements in the noncoding genome.	Science	2016
25748654	Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.	Cell	2015
26375006	BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.	Nature	2015
26189680	A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.	Cell	2015
25830891	In vivo genome editing using Staphylococcus aureus Cas9.	Nature	2015
25854182	High-throughput functional genomics using CRISPR-Cas9.	Nat Rev Genet	2015
25875337	Systematic dissection of the sequence determinants of gene 3' end mediated expression control.	PLoS Genet	2015
24336571	Genome-scale CRISPR-Cas9 knockout screening in human cells.	Science	2014
25075903	Improved vectors and genome-wide libraries for CRISPR screening.	Nat Methods	2014
23505350	Measurements of the impact of 3' end sequences on gene expression reveal wide range and sequence dependent effects.	PLoS Comput Biol	2013
23873081	DNA targeting specificity of RNA-guided Cas9 nucleases.	Nat Biotechnol	2013
22246183	Axonal transcription factors signal retrogradely in lesioned peripheral nerve.	EMBO J	2012
23237624	Widespread promoter-mediated coordination of transcription and mRNA degradation.	Genome Biol	2012
21931566	Transcriptome kinetics is governed by a genome-wide coupling of mRNA production and degradation: a role for RNA Pol II.	PLoS Genet	2011
20628157	Signaling to transcription networks in the neuronal retrograde injury response.	Sci Signal	2010
18854817	Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation.	Mol Syst Biol	2008

1 - 38 of 38

George M Church

Wyss Institute for Biologically Inspired Engineering, Harvard University

Career Start Year 2018

Number of shared co-authors 1

Reuben A Saunders

University of California San Francisco

Career Start Year 2015

Number of shared co-authors 0

Emily C Wheeler

University of California

Career Start Year 2014

Number of shared co-authors 0

Max A Horlbeck

Broad Institute of MIT and Harvard

Career Start Year 2012

Number of shared co-authors 2

Jiewei Xu

Quantitative Biosciences Institute (QBI), University of California san francisco

Career Start Year 2012

Number of shared co-authors 0

Marc G??ell

Universitat Pompeu Fabra

Career Start Year 2009

Number of shared co-authors 1

Lei S Qi

Stanford University

Career Start Year 2008

Number of shared co-authors 2

Luke A Gilbert

Arc Institute

Career Start Year 2007

Number of shared co-authors 2

Shondra M Pruett-Miller

St. Jude Children's Research Hospital.

Career Start Year 2006

Number of shared co-authors 1

Douglas M Fowler

University of Washington, USA Brotman Baty Institute for Precision Medicine

Career Start Year 2006

Number of shared co-authors 0

Alan S L Wong

The University of Hong Kong

Career Start Year 2005

Number of shared co-authors 2

Gene W Yeo

University of California

Career Start Year 2004

Number of shared co-authors 4

Traver Hart

University of Texas MD Anderson Cancer Center

Career Start Year 2004

Number of shared co-authors 0

Prashant Mali (CM4AI)

University of California San Diego

Career Start Year 2004

Number of shared co-authors 6

Martin Kampmann

Institute for Neurodegenerative Diseases, University of California san francisco

Career Start Year 2003

Number of shared co-authors 0

Kevin R Brown

College Street, University of Toronto

Career Start Year 2000

Number of shared co-authors 1

Michelle Nguyen

School of Medicine Stanford University

Career Start Year 2000

Number of shared co-authors 2

John Aach

Harvard Medical School

Career Start Year 2000

Number of shared co-authors 3

Lars M Steinmetz

Stanford University

Career Start Year 1998

Number of shared co-authors 1

David R Powell

Biomedicine Discovery Institute, Monash University

Career Start Year 1998

Number of shared co-authors 0

Nevan J Krogan (CM4AI)

University of California San Francisco

Career Start Year 1998

Number of shared co-authors 14

Michael C Bassik

Stanford University Medical Center

Career Start Year 1997

Number of shared co-authors 4

Jason Moffat

University of Toronto

Career Start Year 1997

Number of shared co-authors 3

Jay Shendure

University of Washington

Career Start Year 1996

Number of shared co-authors 3

J Keith Joung

Massachusetts General Hospital

Career Start Year 1993

Number of shared co-authors 2

Jonathan S Weissman

Whitehead Institute for Biomedical Research

Career Start Year 1991

Number of shared co-authors 10

Frank Buchholz

University Hospital Carl Gustav Carus, Technische Universitat (TU) Dresden

Career Start Year 1989

Number of shared co-authors 3

Michael Snyder

Stanford University

Career Start Year 1981

Number of shared co-authors 11

Pamela A Silver

Harvard Medical School

Career Start Year 1979

Number of shared co-authors 0

George M Church

Harvard Medical School

Career Start Year 1977

Number of shared co-authors 7

row(s) 1 - 30 of 30

Feng Zhang

Massachusetts Institute of Technology, USA Broad Institute

Co-authored papers 15

Eran Segal

Weizmann Institute of Science

Co-authored papers 4

Han Altae-Tran

Broad Institute of Massachusetts Institute of Technology and Harvard

Co-authored papers 3

Casey S Greene

Dartmouth College Geisel School of Medicine, Princeton University, University of Colorado Anschutz Medical Campus, University of Pennsylvania Perelman School of Medicine

Co-authored papers 3

Stuart H Orkin

Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School

Co-authored papers 3

Ryo Higuchi-Sanabria

University of Southern California

Co-authored papers 3

Xihong Lin

Harvard T.H. Chan School of Public Health

Co-authored papers 2

Daniel E Bauer

Co-authored papers 2