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Author Details

Donald M O'Rourke
Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
1991
155
51
PMIDPaper TitleJournal TitlePublished Year
36416495Corrigendum to: EGFR, the Lazarus target for precision oncology in glioblastoma.Neuro Oncol2023
37118754Validation of multiparametric MRI based prediction model in identification of pseudoprogression in glioblastomas.J Transl Med2023
37264082Editorial Expression of Concern: SIRPa1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.Oncogene2023
37129737Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a multiparametric MRI-based prediction model.J Neurooncol2023
36549916Distinguishing Progression from Pseudoprogression in Glioblastoma Using <sup>18</sup>F-Fluciclovine PET.J Nucl Med2023
36765908MRI-Based Radiomics Combined with Deep Learning for Distinguishing IDH-Mutant WHO Grade 4 Astrocytomas from IDH-Wild-Type Glioblastomas.Cancers (Basel)2023
34813961Enhancing CAR T function with the engineered secretion of C. perfringens neuraminidase.Mol Ther2022
35551405Risk of intracranial hemorrhage with direct oral anticoagulants vs low molecular weight heparin in glioblastoma: A retrospective cohort study.Neuro Oncol2022
35507919Immunologic Features in De Novo and Recurrent Glioblastoma Are Associated with Survival Outcomes.Cancer Immunol Res2022
35610333Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma.Sci Rep2022
35603165PD1 Expression in EGFRvIII-Directed CAR T Cell Infusion Product for Glioblastoma Is Associated with Clinical Response.Front Immunol2022
35570396Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors.Mol Ther2022
36458202The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity.Mol Ther Oncolytics2022
35906241The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, &amp; radiomics.Sci Data2022
36125064EGFR, the Lazarus target for precision oncology in glioblastoma.Neuro Oncol2022
35043276MR susceptibility imaging for detection of tumor-associated macrophages in glioblastoma.J Neurooncol2022
35247893Glioblastoma: The Current State of Biology and Therapeutic Strategies.Cancer Res2022
33383491Pathology of macrophage activation syndrome in humanized NSGS mice.Res Vet Sci2021
33521638Multi-institutional noninvasive in vivo characterization of <i>IDH</i>, 1p/19q, and EGFRvIII in glioma using neuro-Cancer Imaging Phenomics Toolkit (neuro-CaPTk).Neurooncol Adv2021
33781506CAR T Cells.Neurosurg Clin N Am2021
33615225Association of plasma cell-free DNA with survival in patients with IDH wild-type glioblastoma.Neurooncol Adv2021
35121889Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma.Nat Cancer2021
34823154Resecting the dominant lesion: Patient outcomes after surgery and radiosurgery vs stand-alone radiosurgery in the setting of multiple brain metastases.Clin Neurol Neurosurg2021
34568006High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms.Front Oncol2021
34294864Quantification of tumor microenvironment acidity in glioblastoma using principal component analysis of dynamic susceptibility contrast enhanced MR imaging.Sci Rep2021
34123793Molecular and Clinical Characterization of UBE2S in Glioma as a Biomarker for Poor Prognosis and Resistance to Chemo-Radiotherapy.Front Oncol2021
34026647Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma.Front Oncol2021
31629009Clinical investigation of CAR T cells for solid tumors: Lessons learned and future directions.Pharmacol Ther2020
32001402Type V Dural Arteriovenous Fistula Supplied by the Artery of Wollschlaeger and Wollschlaeger Causing Cervical Myelopathy and Quadriparesis.World Neurosurg2020
31666247Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study.Clin Cancer Res2020
31916100Potential of Glioblastoma-Targeted Chimeric Antigen Receptor (CAR) T-Cell Therapy.CNS Drugs2020
32102932Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma.Sci Transl Med2020
33099328An additive score optimized by a genetic learning algorithm predicts readmission risk after glioblastoma resection.J Clin Neurosci2020
32690110A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features.Acta Neuropathol Commun2020
32152622AI-based prognostic imaging biomarkers for precision neuro-oncology: the ReSPOND consortium.Neuro Oncol2020
32271286Immunotherapy and Response Assessment in Malignant Glioma: Neuro-oncology Perspective.Top Magn Reson Imaging2020
32140683Imaging and histopathologic correlates of plasma cell-free DNA concentration and circulating tumor DNA in adult patients with newly diagnosed glioblastoma.Neurooncol Adv2020
32129893Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma.Cancer2020
32191542Cancer Imaging Phenomics via CaPTk: Multi-Institutional Prediction of Progression-Free Survival and Pattern of Recurrence in Glioblastoma.JCO Clin Cancer Inform2020
29676844Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI.J Magn Reson Imaging2019
31815646Immune landscapes associated with different glioblastoma molecular subtypes.Acta Neuropathol Commun2019
31807732Rapid and ultrasensitive digital PCR (dPCR) profiling of EGFRvIII in tumor cells and tissues.Neurooncol Adv2019
31920606Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification of <i>de novo</i> Glioblastoma Patients.Front Comput Neurosci2019
31769726Clinical activity of the <i>EGFR</i> tyrosine kinase inhibitor osimertinib in <i>EGFR</i>-mutant glioblastoma.CNS Oncol2019
31217496Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma.Sci Rep2019
31320597A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma.Clin Cancer Res2019
31206012Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in Glioblastoma.Acad Pathol2019
31542863Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma.J Neurooncol2019
31218139Evaluating the Association Between the Extent of Resection and Survival in Gliosarcoma.Cureus2019
30926557LACE+ Index as Predictor of 30-Day Readmission in Brain Tumor Population.World Neurosurg2019
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Collaborators

Co-authored papers 28
University of Pennsylvania
Co-authored papers 19
University of Maryland School of Medicine
Co-authored papers 18
Collegeville
Co-authored papers 15
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 12
Massachusetts General Hospital
Co-authored papers 10
Richards Medical Research Laboratories (S.B.)
Co-authored papers 10
Weill Cornell Medical College
Co-authored papers 10
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Co-authored papers 7
Lenox Hill Hospital
Co-authored papers 6
The Wistar Institute
Co-authored papers 6
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 6
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 6
Co-authored papers 6
University of Pennsylvania Department of Pathology & Laboratory Medicine
Co-authored papers 5
Co-authored papers 5
University of Pennsylvania.
Co-authored papers 5
Foundational Immunology, AbbVie Cambridge Research Center
Co-authored papers 4
Center for Intelligent Imaging (ci2), University of California san francisco
Co-authored papers 4
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 4
University of Pennsylvania
Co-authored papers 3
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 3
National Cancer Institute
Co-authored papers 3
Stevens Neuroimaging and Informatics Institute, University of Southern California
Co-authored papers 3
University of Pennsylvania
Co-authored papers 3
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University of California San Diego
Co-authored papers 3
University Hospital and University of Zurich
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University of Pennsylvania Medical Center
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