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Author Details

Yungui Zhou
Gladstone Institutes
2001
30
25
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35063084Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.Cell2022
35413950Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.Nat Commun2022
34426831BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis.Brain2021
34851693AD-linked R47H-<i>TREM2</i> mutation induces disease-enhancing microglial states via AKT hyperactivation.Sci Transl Med2021
32792571Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.Sci Rep2020
31873194Microglial microRNAs mediate sex-specific responses to tau pathology.Nat Neurosci2020
33054973A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.Elife2020
30735499Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.PLoS Biol2019
31206174Decreased A20 expression on circulating CD56<sup>bright</sup> NK cells contributes to a worse disease status in patients with ankylosing spondylitis.Clin Exp Immunol2019
30232263Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.Proc Natl Acad Sci U S A2018
29124108An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from <i>GRN</i> gene mutations.Alzheimers Dement (N Y)2017
27041503Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.Neuron2016
27356871Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.Mol Neurodegener2016
25589773SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.J Neurosci2015
26390242Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.Nat Med2015
25261995Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Nat Med2014
22272874Selective targeting of microglia by quantum dots.J Neuroinflammation2012
23024364Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.J Biol Chem2012
21771791CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.J Biol Chem2011
20869593Acetylation of tau inhibits its degradation and contributes to tauopathy.Neuron2010
19951690Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.Cell Stem Cell2009
18957217Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Neuron2008
18931664Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.Nat Neurosci2008
16982417Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.Neuron2006
15699179Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation.J Immunol2005
16183991SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.J Biol Chem2005
12055248A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans.J Immunol2002
12224067Prenatal diagnosis and carrier detection for Athabascan severe combined immunodeficiency disease.Prenat Diagn2002
12444116Multilineage engraftment with minimal graft-versus-host disease following in utero transplantation of S-59 psoralen/ultraviolet a light-treated, sensitized T cells and adult T cell-depleted bone marrow in fetal mice.J Immunol2002
11740386Increased engraftment and GVHD after in utero transplantation of MHC-mismatched bone marrow cells and CD80low, CD86(-) dendritic cells in a fetal mouse model.Transplantation2001
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Collaborators

Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 21
Harvard Medical School
Co-authored papers 10
Gladstone Institutes
Co-authored papers 7
Gladstone Institute of Neurological Disease, Gladstone Institutes
Co-authored papers 6
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Co-authored papers 6
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Co-authored papers 6
Dokkyo Medical University
Co-authored papers 5
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Co-authored papers 5
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Co-authored papers 4
National Institute of Neurological, National Institutes of Health (NIH)
Co-authored papers 4
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 4
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 3
Feil Family Brain and Mind Research Institute
Co-authored papers 3
University of Alberta
Co-authored papers 3
University of California San Francisco
Co-authored papers 2
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 2
Jiangsu Simcere Pharmaceutical Co. Ltd.
Co-authored papers 2
Stanford University School of Medicine
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Gladstone Institute for Neurological Disease San Francisco
Co-authored papers 2
Gladstone Institute of Neurological Disease
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Rockefeller University
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National Institute On Aging
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Buck Institute for Research on Aging
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Gladstone Institutes
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Harvard T.H. Chan School of Public Health
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Institute for Neurodegenerative Diseases, University of California San Francisco
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The University of Texas at San Antonio
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Quantitative Biosciences Institute (QBI), University of California san francisco
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