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Author Details

James C Costello
University of Colorado Anschutz Medical Campus
2006
73
31
PMIDPaper TitleJournal TitlePublished Year
36711769curatedPCaData: Integration of clinical, genomic, and signature features in a curated and harmonized prostate cancer data resource.bioRxiv2023
37554445Down syndrome is associated with altered frequency and functioning of tracheal multiciliated cells, and response to influenza virus infection.iScience2023
37407670A harmonized resource of integrated prostate cancer clinical, -omic, and signature features.Sci Data2023
37468459SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma.Nat Commun2023
37224225Non-muscle-invasive bladder cancer molecular subtypes predict differential response to intravesical Bacillus Calmette-Guérin.Sci Transl Med2023
36820825Microparticle-Delivered Cxcl9 Prolongs Braf Inhibitor Efficacy in Melanoma.Cancer Immunol Res2023
35132438PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation.Development2022
36142576High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes.Int J Mol Sci2022
36139558Antigens Expressed by Breast Cancer Cells Undergoing EMT Stimulate Cytotoxic CD8<sup>+</sup> T Cell Immunity.Cancers (Basel)2022
36216026SOPHIE: Generative Neural Networks Separate Common and Specific Transcriptional Responses.Genomics Proteomics Bioinformatics2022
33947745Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast.Mol Cancer Res2021
33846123<i>MAP3K7</i> Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of <i>CHD1</i>.Mol Cancer Res2021
33526513Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer.Cancer Res2021
34544797IL13Rα2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases.Clin Cancer Res2021
34208794Androgen Receptor Signaling in Prostate Cancer Genomic Subtypes.Cancers (Basel)2021
34195686Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.Cell Rep Med2021
32460014Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.Cell Rep2020
31974170Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.Cancer Discov2020
33196691KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma.Oncotarget2020
33247183Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy.Commun Biol2020
33218188CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer.Cancers (Basel)2020
33096022Biologically Informed Neural Networks Predict Drug Responses.Cancer Cell2020
32697014KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma.Mol Oncol2020
32276990Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers.Mol Cancer Res2020
30414698A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer.Eur Urol2019
37736115Modeling genetic heterogeneity of drug response and resistance in cancer.Curr Opin Syst Biol2019
31300540Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination.Mol Cancer Res2019
31628327Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.Nat Commun2019
30801016Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy.Sci Adv2019
30606720SIX2 Mediates Late-Stage Metastasis via Direct Regulation of <i>SOX2</i> and Induction of a Cancer Stem Cell Program.Cancer Res2019
29732388Systematic Review: Characteristics and Preclinical Uses of Bladder Cancer Cell Lines.Bladder Cancer2018
29887378Next-Generation Machine Learning for Biological Networks.Cell2018
30127018Metastatic cells are preferentially vulnerable to lysosomal inhibition.Proc Natl Acad Sci U S A2018
29879983Simulating heterogeneous populations using Boolean models.BMC Syst Biol2018
30112438A Gene Expression Signature Predicts Bladder Cancer Cell Line Sensitivity to EGFR Inhibition.Bladder Cancer2018
29950010GSEA-InContext: identifying novel and common patterns in expression experiments.Bioinformatics2018
29757193Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation.J Clin Invest2018
27270441Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.Oncogene2017
30657384A DREAM Challenge to Build Prediction Models for Short-Term Discontinuation of Docetaxel in Metastatic Castration-Resistant Prostate Cancer.JCO Clin Cancer Inform2017
29281820Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.Cell Rep2017
28958384All Paths Lead to TRIM25.Trends Cancer2017
29137211Community mining of open clinical trial data.Oncotarget2017
27897011A SPATIOTEMPORAL MODEL TO SIMULATE CHEMOTHERAPY REGIMENS FOR HETEROGENEOUS BLADDER CANCER METASTASES TO THE LUNG.Pac Symp Biocomput2017
27864015Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data.Lancet Oncol2017
27312530GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis.Cancer Res2016
26248648Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics.Mol Cancer Res2016
27653685Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.Cell Rep2016
27418159Crowdsourcing biomedical research: leveraging communities as innovation engines.Nat Rev Genet2016
25516960RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer.Mol Cancer Res2015
25722414Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.Science2015
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Collaborators

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Co-authored papers 7
Wyss Institute for Biologically Inspired Engineering, Harvard University
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Dartmouth College Geisel School of Medicine, Princeton University, University of Colorado Anschutz Medical Campus, University of Pennsylvania Perelman School of Medicine
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The Prostate Cancer Clinical Trials Consortium
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Bill & Melinda Gates Foundation
Co-authored papers 3
Oregon Health Sciences University
Co-authored papers 3
University of Colorado Anschutz Medical Campus
Co-authored papers 3
Massachusetts Institute of Technology
Co-authored papers 2
Tulane University School of Medicine
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National Cancer Institute
Co-authored papers 2
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Helsinki Institute for Information Technology (HIIT), Aalto University
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Huntsman Cancer Institute, The University of Utah
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