Author details

Full Name

Nathanael J Spann

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37322178	SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.	Nat Immunol	2023
37751740	RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1Î²- and RNA-dependent co-activator of osteoclast gene expression.	Mol Cell	2023
37735593	Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes.	Nat Immunol	2023
37582369	Human microglia maturation is underpinned by specific gene regulatory networks.	Immunity	2023
35049498	Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs.	Elife	2022
36097162	SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus.	Nat Commun	2022
35672450	ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge's disease.	Exp Mol Med	2022
36417856	DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.	Cell Rep	2022
34852229	Altered H3 histone acetylation impairs high-fidelity DNA repair to promote cerebellar degeneration in spinocerebellar ataxia type 7.	Cell Reports	2021
33718886	An optimized protocol for rapid, sensitive and robust on-bead ChIP-seq from primary cells.	STAR Protoc	2021
34134993	Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4.	Sci Adv	2021
31761566	Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis.	Cell Metab	2020
31959980	Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung.	Nat Immunol	2020
32362324	Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.	Immunity	2020
30679424	Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages.	Nat Commun	2019
31587991	Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.	Immunity	2019
29632203	Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages.	Proc Natl Acad Sci U S A	2018
29779944	Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.	Cell	2018
28041958	SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism.	Cell Metab	2017
29035364	Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine.	Nat Med	2017
27462873	Tissue damage drives co-localization of NF-ÎºB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages.	Elife	2016
26193633	Transcription factor ISL1 is essential for pacemaker development and function.	J Clin Invest	2015
25598080	Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.	J Lipid Res	2015
25007801	Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.	EMBO Mol Med	2014
25480297	Environment drives selection and function of enhancers controlling tissue-specific macrophage identities.	Cell	2014
23273843	The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.	Immunity	2013
24074869	NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids.	Cell	2013
24189069	25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.	J Biol Chem	2013
23932714	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	Mol Cell	2013
23959186	Sterols and oxysterols in immune cell function.	Nat Immunol	2013
23063365	The transcriptional specificity of NF-ÎºB dimers is coded within the ÎºB DNA response elements.	Cell Rep	2012
22921934	Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.	Mol Cell	2012
23021221	Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.	Cell	2012
22174696	Mechanisms establishing TLR4-responsive activation states of inflammatory response genes.	PLoS Genet	2011
20513432	Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.	Mol Cell	2010
21045807	FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages.	EMBO J	2010
18322014	Txnip balances metabolic and growth signaling via PTEN disulfide reduction.	Proceedings of the National Academy of Sciences of the United States of America	2008
16950764	Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis.	Journal of Biological Chemistry	2006
12777384	ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1.	Journal of Biological Chemistry	2003
11907135	Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP.	Journal of Lipid Research	2002