Author details

Full Name

Bridget K Wagner

Affiliation

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36914634	Reference compounds for characterizing cellular injury in high-content cellular morphology assays.	Nat Commun	2023
37339634	Excess pancreatic elastase alters acinar-Î² cell communication by impairing the mechano-signaling and the PAR2 pathways.	Cell Metab	2023
36639508	Identifying type 2 diabetes risk genes by Î²-cell CRISPR screening.		2023
37075753	FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.	Cell Metab	2023
36865221	FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.	bioRxiv	2023
35331962	Emerging diabetes therapies: Bringing back the Î²-cells.	Molecular Metabolism	2022
35594847	Chemical strategies to understand and manipulate host-pathogen interactions.	Cell Chemical Biology	2022
36044849	SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression.	Cell Rep	2022
35439415	Phenotypic Screening for Small Molecules that Protect Î²-Cells from Glucolipotoxicity.	ACS Chem Biol	2022
35487100	Small-molecule discovery in the pancreatic beta cell.	Current Opinion in Chemical Biology	2022
36396978	A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.	Nat Cell Biol	2022
34669463	Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension.	Sci Adv	2021
34130532	The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.	SLAS Discov	2021
33592188	Nuisance compounds in cellular assays.	Cell Chemical Biology	2021
33740431	Phenotypic approaches to small-molecule discovery in chemical biology.	Cell Chemical Biology	2021
34224917	From type 1 diabetes biology to therapy: The Human Islet Research Network.	Mol Metab	2021
34218710	Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Guidelines.	SLAS Discovery	2021
33514654	Harnessing reaction-based probes to preferentially target pancreatic Î²-cells and Î²-like cells.	Life Sci Alliance	2021
33137873	Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in Î²-Cells.	International Journal of Molecular Sciences	2020
32302581	The Role of Chemical Biology in the Discovery and Understanding of Ferroptosis.	Cell Chemical Biology	2020
32175731	Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in Î²-Cells.	J Am Chem Soc	2020
33208361	A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of Î² cells.	Sci Adv	2020
31051099	A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.	Cell	2019
31086331	Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.	Nature Chemical Biology	2019
30962421	A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.	Nat Commun	2019
30339956	When Small Molecules Are Like Real Estate: It's All about Location, Location, Location.	Cell Chemical Biology	2018
28438776	The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.	Journal of Endocrinology	2017
28860191	Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.	Journal of Biological Chemistry	2017
28461505	Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.	Proc Natl Acad Sci U S A	2017
28666119	Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.	Cell	2017
27667365	A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure.	Cell Syst	2016
26933731	The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.	Cell Chem Biol	2016
27329954	The Genetic Landscape of Î²-Cell Proliferation: Toward a Road Map.		2016
26953159	Inhibition of DYRK1A Stimulates Human Î²-Cell Proliferation.	Diabetes	2016
27398798	Real-Time Biological Annotation of Synthetic Compounds.	J Am Chem Soc	2016
26656090	Correlating chemical sensitivity and basal gene expression reveals mechanism of action.	Nat Chem Biol	2016
26656089	Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.	Nat Chem Biol	2016
26640968	An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in Î²-Cell Protection.	ACS Chemical Biology	2016
26593688	The resurgence of phenotypic screening in drug discovery and development.	Expert Opinion on Drug Discovery	2016
25062500	HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent.	Journal of Interferon and Cytokine Research	2015
25498789	Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.	Trends Genet	2015
25569027	Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides.	Org Lett	2015
25565210	High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function.	Cell Metab	2015
26042473	Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.	J Am Chem Soc	2015
26244933	Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes.	Cell Metab	2015
24710340	Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.	J Biomol Screen	2014
24464433	Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.	J Biomol Screen	2014
25205564	Evaluation of compounds in primary human islet cell culture.	Current protocols in chemical biology	2014
24811789	Inhibition of HDAC3 as a strategy for developing novel diabetes therapeutics.	Epigenomics	2014
24759943	Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming.	PLoS One	2014