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Author Details

John D Gross
Department of Pharmaceutical Chemistry, University of California san francisco
1995
72
32
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36657879A call to order: Examining structured domains in biomolecular condensates.J Magn Reson2023
36754086The structural basis for HIV-1 Vif antagonism of human APOBEC3G.Nature2023
35018374SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.bioRxiv2022
35576528Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9.ACS Chem Biol2022
36095012SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.PLoS Pathog2022
35290794Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis.Structure2022
33439620Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect.ACS Chem Biol2021
33767388Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation.Nat Chem Biol2021
33983947Identification of recombinant Fabs for structural and functional characterization of HIV-host factor complexes.PLoS One2021
32513655Pdc2/Pat1 increases the range of decay factors and RNA bound by the Lsm1-7 complex.RNA2020
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
30575809Publisher Correction: Structural and molecular mechanisms for the control of eukaryotic 5'-3' mRNA decay.Nat Struct Mol Biol2019
31690658Pat1 activates late steps in mRNA decay by multiple mechanisms.Proc Natl Acad Sci U S A2019
31830442Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.Cell Host Microbe2019
32493764Biophysical Properties of HP1-Mediated Heterochromatin.Cold Spring Harb Symp Quant Biol2019
31618757HP1 reshapes nucleosome core to promote phase separation of heterochromatin.Nature2019
30961890Conformational Dynamics of the HIV-Vif Protein Complex.Biophys J2019
29101277Application of a <i>Schizosaccharomyces pombe</i> Edc1-fused Dcp1-Dcp2 decapping enzyme for transcription start site mapping.RNA2018
30166453CRL4<sup>AMBRA1</sup> targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.EMBO J2018
30518847Structural and molecular mechanisms for the control of eukaryotic 5'-3' mRNA decay.Nat Struct Mol Biol2018
30455174Decapping enzymes STOP "cancer" ribosomes in their tracks.EMBO J2018
30308158A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability.Cell Host Microbe2018
29618050Control of mRNA decapping by autoinhibition.Nucleic Acids Res2018
29559651Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis.Nat Commun2018
29304101Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.PLoS Pathog2018
28002405Molecular biology: Messenger RNAs marked for longer life.Nature2017
28104838Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler.Science2017
28299671CBFÿ and HIV Infection.Adv Exp Med Biol2017
28942089Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.J Mol Biol2017
28961413Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription.Annu Rev Virol2017
26826132Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.RNA2016
27694842Structural basis of mRNA-cap recognition by Dcp1-Dcp2.Nat Struct Mol Biol2016
25981045Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.Cell Rep2015
26422686Thermodynamics of Rev-RNA interactions in HIV-1 Rev-RRE assembly.Biochemistry2015
24904166A mutually assured destruction mechanism attenuates light signaling in Arabidopsis.Science2014
23352243From systems to structure: bridging networks and mechanism.Mol Cell2013
23911090Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2.Structure2013
23728292The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals.Nat Struct Mol Biol2013
23582258Judge, jury, and executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control.Mol Cell2013
23333304CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression.Mol Cell2013
22323607Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.Proc Natl Acad Sci U S A2012
23300442Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.PLoS Pathog2012
22760860The crystal structure of the periplasmic domain of Vibrio parahaemolyticus CpxA.Protein Sci2012
21148770Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition.RNA2011
22190037Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.Nature2011
20086104Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae.Mol Cell Biol2010
20799348The crystal structure Escherichia coli Spy.Protein Sci2010
20711189A split active site couples cap recognition by Dcp2 to activation.Nat Struct Mol Biol2010
20400949Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila.Nat Struct Mol Biol2010
19389408An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model.J Mol Biol2009
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Collaborators

Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 10
Dong Young Kim
Seoul National University College of Medicine, Seoul National University Hospital
Co-authored papers 8
Stephen N Floor
University of California san francisco
Co-authored papers 8
David J Stanley
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 6
Jennifer M Binning
H. Lee Moffitt Cancer Center and Research Institute
Co-authored papers 5
Eunju Kwon
Yeungnam University
Co-authored papers 5
Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 5
Judd F Hultquist
Northwestern University Feinberg School of Medicine
Co-authored papers 4
Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 4
Reuben S Harris
University of Texas Health San Antonio
Co-authored papers 4
Geeta J Narlikar
University of California san francisco
Co-authored papers 4
Alan D Frankel
University of California san francisco
Co-authored papers 3
Lily Burton
University of Chicago
Co-authored papers 3
Melanie Ott
Gladstone Institute of Virology
Co-authored papers 3
Ming Li
Department of Cancer Research Institute, University of South Australia
Co-authored papers 3
Michael J Trnka
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 3
James S Fraser
University of California san francisco
Co-authored papers 3
Yifan Cheng
Quantitative Bioscience Institute, University of California san francisco
Co-authored papers 3
Michael Emerman
Fred Hutchinson Cancer Center
Co-authored papers 3
Eric Verdin
Buck Institute for Research on Aging
Co-authored papers 3
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Marius Walter
Buck Institute for Research on Aging
Co-authored papers 2
Stefanie J??ger
Institute of Molecular Biosciences, Goethe University Frankfurt
Co-authored papers 2
Birgit Schilling
Buck Institute for Research on Aging
Co-authored papers 2
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 2
David E Gordon
Emory University
Co-authored papers 2
Boris Matija Peterlin
University of California at San Francisco
Co-authored papers 2
Carol A Gross
University of California san francisco
Co-authored papers 2
Kathleen E Franks-Skiba
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 2
Hiroshi Matsuo
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Release 1.2