Author details

Full Name

Melvin I Simon

Affiliation

ORCID

Career Start Year

1962

Papers

310

H Index

119

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
26912691	RETROSPECTIVE. Alfred Gilman (1941-2015).	Science	2016
23703906	Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis.	EMBO Mol Med	2013
23513224	Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.	Proceedings of the National Academy of Sciences of the United States of America	2013
22609986	PRR5L degradation promotes mTORC2-mediated PKC-Î´ phosphorylation and cell migration downstream of GÎ±12.	Nat Cell Biol	2012
21868356	Intracellular signaling and the origins of the sensations of itch and pain.	Science Signaling	2011
21036901	Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.	Journal of Biological Chemistry	2011
21300878	Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons.	Proceedings of the National Academy of Sciences of the United States of America	2011
21972468	Intracellular signaling and the origins of the sensations of itch and pain.	Science Signaling	2011
20624888	G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.	J Exp Med	2010
20679217	NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.	Proceedings of the National Academy of Sciences of the United States of America	2010
20959081	Variability in G-protein-coupled signaling studied with microfluidic devices.	Biophys J	2010
19454649	Deciphering signaling outcomes from a system of complex networks.	Sci Signal	2009
19531803	Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105.	Science Signaling	2009
19564617	TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.	Proceedings of the National Academy of Sciences of the United States of America	2009
18411281	Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.	Journal of Biological Chemistry	2008
18434540	Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation.	Proceedings of the National Academy of Sciences of the United States of America	2008
17192258	The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.	Mol Cell Proteomics	2007
17938235	Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes.	J Exp Med	2007
17360531	Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation.	Proceedings of the National Academy of Sciences of the United States of America	2007
17971228	A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs.	BMC Molecular Biology	2007
16421323	Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.	Journal of Neuroscience	2006
16510108	Identification of small molecule antagonists of the human mas-related gene-X1 receptor.	Analytical Biochemistry	2006
16945906	A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression.	Proceedings of the National Academy of Sciences of the United States of America	2006
16982864	Dual ligand stimulation of RAW 264.7 cells uncovers feedback mechanisms that regulate TLR-mediated gene expression.	J Immunol	2006
17114052	Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons.	Neuron	2006
15994328	Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA.	Journal of Biological Chemistry	2005
15983374	Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins.	Proc Natl Acad Sci U S A	2005
15746409	An open letter to Elias Zerhouni.	Science	2005
15728856	D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.	Journal of Neuroscience	2005
14699051	Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA.	Proc Natl Acad Sci U S A	2004
15541899	Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration.	Neuroscience	2004
15321722	Helical shifts generate two distinct conformers in the atomic resolution structure of the CheA phosphotransferase domain from Thermotoga maritima.	Journal of Molecular Biology	2004
15585835	Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands.	J Immunol	2004
15289606	In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved.	Proceedings of the National Academy of Sciences of the United States of America	2004
15173221	Recoverin regulates light-dependent phosphodiesterase activity in retinal rods.	Journal of General Physiology	2004
12818179	RGS9 modulates dopamine signaling in the basal ganglia.	Neuron	2003
12494451	Galphaq signaling is required for Rho-dependent transcriptional activation of the cyclooxygenase-2 promoter in fibroblasts.	Journal of Cellular Physiology	2003
14610022	Novel form of adaptation in mouse retinal rods speeds recovery of phototransduction.	Journal of General Physiology	2003
12738888	Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5.	Proceedings of the National Academy of Sciences of the United States of America	2003
14528298	G13 is an essential mediator of platelet activation in hemostasis and thrombosis.	Nature Medicine	2003
12611815	Methacholine-induced airway hyperresponsiveness is dependent on Galphaq signaling.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2003
12904457	Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice.	Journal of Neuroscience	2003
14704167	Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle.	Genetics	2003
12960402	A quantitative characterization of the yeast heterotrimeric G protein cycle.	Proceedings of the National Academy of Sciences of the United States of America	2003
12716919	Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling.	Journal of Neuroscience	2003
12954641	Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.	J Biol Chem	2003
11980885	Bax is not the heterodimerization partner necessary for sustained anti-photoreceptor-cell-death activity of Bcl-2.	Investigative Ophthalmology and Visual Science	2002
12397184	Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.	Proceedings of the National Academy of Sciences of the United States of America	2002
11907117	Gq signaling is required for allergen-induced pulmonary eosinophilia.	Journal of Immunology	2002
12219089	Evidence for two apoptotic pathways in light-induced retinal degeneration.	Nature Genetics	2002