Author details

Full Name

John P Giddens

Affiliation

ORCID

Career Start Year

2012

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36683157	Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb.		2023
35480883	Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs.	Frontiers in Molecular Biosciences	2022
32700053	Principal component analysis for automated classification of 2D spectra and interferograms of protein therapeutics: influence of noise, reconstruction details, and data preparation.	Journal of Biomolecular NMR	2020
32267681	Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional H,C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies.	Analytical Chemistry	2020
30917003	Glycoengineering of Antibodies for Modulating Functions.	Annual Review of Biochemistry	2019
29806004	Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine.	ACS Central Science	2018
30397147	Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody.	Proceedings of the National Academy of Sciences of the United States of America	2018
30384610	Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition.	Journal of Medicinal Chemistry	2018
29958062	Heterologous recombinant expression of non-originator NISTmAb.	mAbs	2018
29385073	Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies.	International Journal of Molecular Sciences	2018
28289219	Modulating IgG effector function by Fc glycan engineering.	Proceedings of the National Academy of Sciences of the United States of America	2017
28466900	Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies.	Chemical Communications	2017
28414420	Systematic Synthesis and Binding Study of HIV V3 Glycopeptides Reveal the Fine Epitopes of Several Broadly Neutralizing Antibodies.	ACS Chemical Biology	2017
29107699	Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses.	Cell Chemical Biology	2017
26514686	Evaluation of a glycoengineered monoclonal antibody via LC-MS analysis in combination with multiple enzymatic digestion.	mAbs	2016
27432157	An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosineâ¿¿2A Receptor.	Chembiochem	2016
27288408	Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling.	Journal of Biological Chemistry	2016
26966183	Endo-F3 Glycosynthase Mutants Enable Chemoenzymatic Synthesis of Core-fucosylated Triantennary Complex Type Glycopeptides and Glycoproteins.	Journal of Biological Chemistry	2016
26082235	Chemoenzymatic Glyco-engineering of Monoclonal Antibodies.	Methods in Molecular Biology	2015
26436649	Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity.	Journal of Clinical Investigation	2015
24702330	Chemoenzymatic Fc glycosylation via engineered aldehyde tags.	Bioconjug Chem	2014
24753590	Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.	Proc Natl Acad Sci U S A	2014
24533830	An Fc domain protein-small molecule conjugate as an enhanced immunomodulator.	J Am Chem Soc	2014
25036289	Structural characterization of anti-inflammatory immunoglobulin G Fc proteins.	Journal of Molecular Biology	2014
22747414	Chemoenzymatic glycoengineering of intact IgG antibodies for gain of functions.	Journal of the American Chemical Society	2012