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Author Details

David M Briscoe
Boston Children's Hospital
1987
97
40
PMIDPaper TitleJournal TitlePublished Year
36799932Assessing Vulnerability to COVID-19 in High-Risk Populations: The Role of SARS-CoV-2 Spike-Targeted Serology.Popul Health Manag2023
34687147Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4<sup>+</sup> T cells.Am J Transplant2022
34965300A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation.Carcinogenesis2022
31541025T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4<sup>+</sup> T Regulatory Cell Activity In Vivo following Transplantation.J Immunol2019
29969188DEPTOR modulates activation responses in CD4<sup>+</sup> T cells and enhances immunoregulation following transplantation.Am J Transplant2019
31542230Calcineurin inhibitors augment endothelial-to-mesenchymal transition by enhancing proliferation in association with cytokine-mediated activation.Biochem Biophys Res Commun2019
29382882Convergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes.Sci Rep2018
29897294DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.Physiol Rev2018
29446208Study rationale, design, and pretransplantation alloantibody status: A first report of Clinical Trials in Organ Transplantation in Children-04 (CTOTC-04) in pediatric heart transplantation.Am J Transplant2018
27865734Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients.J Heart Lung Transplant2017
27898465The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance.Curr Opin Organ Transplant2017
25903640Translational implications of endothelial cell dysfunction in association with chronic allograft rejection.Pediatr Nephrol2016
26260101Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study.Am J Transplant2016
27498384Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients.J Heart Lung Transplant2016
27430720Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo.J Immunol2016
25563987Chronic allograft rejection: a fresh look.Curr Opin Organ Transplant2015
26325525Microfluidic mazes to characterize T-cell exploration patterns following activation in vitro.Integr Biol (Camb)2015
26156437Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.Sci Rep2015
25675207Use of [18F]FDG Positron Emission Tomography to Monitor the Development of Cardiac Allograft Rejection.Transplantation2015
25183261Microfluidic platform for the quantitative analysis of leukocyte migration signatures.Nat Commun2014
22989616Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12.Cytokine Growth Factor Rev2013
23881914DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses.Blood2013
24013197Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.Nat Biotechnol2013
23260712VEGF-C, VEGF-A and related angiogenesis factors as biomarkers of allograft vasculopathy in cardiac transplant recipients.J Heart Lung Transplant2013
22326918TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor.Biochem Biophys Res Commun2012
23369287Differential activation of human T cells to allogeneic endothelial cells, epithelial cells and fibroblasts in vitro.Transplant Res2012
22863981Targeting the intragraft microenvironment and the development of chronic allograft rejection.Hum Immunol2012
22828505Constitutive activation of the mTOR signaling pathway within the normal glomerulus.Biochem Biophys Res Commun2012
22670785Peripherally circulating CD4⁺ FOXP3⁺ CXCR3⁺ T regulatory cells correlate with renal allograft function.Scand J Immunol2012
22566935Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation.Front Immunol2012
21538345Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3.Eur J Immunol2011
20008289Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production.J Immunol2010
20847093Cost-related immunosuppressive medication nonadherence among kidney transplant recipients.Clin J Am Soc Nephrol2010
20538805Effect of vascular endothelial growth factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo.Blood2010
19903851Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells.Cancer Res2009
18091722Assessing the vascular effects of early erythropoietin use in pediatric renal transplant recipients.Nat Clin Pract Nephrol2008
19100913mTOR-understanding the clinical effects.Transplant Proc2008
18832436Calcineurin inhibitors modulate CXCR3 splice variant expression and mediate renal cancer progression.J Am Soc Nephrol2008
19018001CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo.J Immunol2008
18632621Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer.Cancer Res2008
17652371Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells.Am J Physiol Renal Physiol2007
18060023Every allograft needs a silver lining.J Clin Invest2007
17589343Organ-specific differences in the function of MCP-1 and CXCR3 during cardiac and skin allograft rejection.Transplantation2007
17553806The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells.J Biol Chem2007
16493069Vascular endothelial growth factor-induced signaling pathways in endothelial cells that mediate overexpression of the chemokine IFN-gamma-inducible protein of 10 kDa in vitro and in vivo.J Immunol2006
17018607Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer.Cancer Res2006
16904613Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.Cancer Cell2006
16481411Angiogenesis and endothelial cell repair in renal disease and allograft rejection.J Am Soc Nephrol2006
16436682Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury.Am J Pathol2006
16033859CD40: a mediator of pro- and anti-inflammatory signals in renal tubular epithelial cells.J Am Soc Nephrol2005
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Collaborators

Sarah Bruneau
Centre Hospitalier Universitaire de Nantes, Nantes Universite, Inserm
Co-authored papers 10
Johannes Wedel
Boston Children's Hospital
Co-authored papers 8
Evelyn Flynn
Boston Children's Hospital
Co-authored papers 8
Tatsuichiro Seto
Shinshu University School of Medicine
Co-authored papers 5
Kaifeng Liu
Boston Children's Hospital
Co-authored papers 4
Maria Stack
Children's Hospital Ireland at Temple Street
Co-authored papers 4
David Zurakowski
Harvard Medical School, Boston Children's Hospital
Co-authored papers 3
Sek Won Kong
Boston Children's Hospital, Seoul National University, Seoul National University Hospital
Co-authored papers 3
Gearoid M McMahon
Brigham and Women's Hospital, MA Harvard Medical School
Co-authored papers 3
Rakesh K Jain
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 2
Isaac E Stillman
Mount Sinai Hospital
Co-authored papers 2
Elizabeth D Blume
Boston Children's Hospital
Co-authored papers 2
Mathieu Laplante
Centre de recherche sur le cancer de l'Universite Laval, Universite Laval
Co-authored papers 2
Chandra C Ghosh
The Wistar Institute
Co-authored papers 2
Subbian Ananth Karumanchi
Co-authored papers 1
Jeffrey P Kahn
Berman Institute of Bioethics, Johns Hopkins University
Co-authored papers 1
Kenneth Walsh
University of Virginia School of Medicine
Co-authored papers 1
Sayantan Bose
Bose Institute
Co-authored papers 1
Daniel J Rader
Co-authored papers 1
Amy J Wagers
Joslin Diabetes Center
Co-authored papers 1
William T Pu
Boston Children's Hospital, Harvard Medical School
Co-authored papers 1
Matthew M Sheehan
Boston Children's Hospital
Co-authored papers 1
Sebastian K??hler
Division of Emergency Medicine University of Calgary Calgary Alberta Canada.
Co-authored papers 1
Craig W Lillehei
Boston Children's Hospital
Co-authored papers 1
Thorsten Feldkamp
University Hospital Schleswig-Holstein, Christian-Albrechts-University
Co-authored papers 1
Daniel Goodman
Boston Children's Hospital
Co-authored papers 1
Timothy E Bunchman
Children's Hospital of Richmond
Co-authored papers 1
Alexander von Gise
Hannover Medical School
Co-authored papers 1
Stuart J Youngner
Case Western Reserve University
Co-authored papers 1
A G Pramoda Sahankumari
Boston Children's Hospital
Co-authored papers 1
Release 1.2