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Author Details

Glenn S Cowley
Broad Institute of Harvard and MIT
1990
58
38
PMIDPaper TitleJournal TitlePublished Year
37773632Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma.Clin Cancer Res2023
35016204Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion.Blood Adv2022
36329185The methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation.Commun Biol2022
32483149A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor.Nat Commun2020
30664779Small-molecule targeting of brachyury transcription factor addiction in chordoma.Nat Med2019
31070582Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis.Elife2019
31160565Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.Nat Commun2019
30373918Cells Lacking the <i>RB1</i> Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.Cancer Discov2019
29202477CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.J Clin Invest2018
30181297Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic.Proc Natl Acad Sci U S A2018
30042095Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4[CRBN] activity.Blood2018
28655788PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.Cancer Res2017
28436985Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.Nat Genet2017
28396387<i>PIK3CA</i> mutant tumors depend on oxoglutarate dehydrogenase.Proc Natl Acad Sci U S A2017
28178529ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.Cell Rep2017
28177281Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Elife2017
29083409Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.Nat Genet2017
28988802A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.Cell Syst2017
29203668Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden.Proc Natl Acad Sci U S A2017
28753430Defining a Cancer Dependency Map.Cell2017
28701475HIF activation causes synthetic lethality between the <i>VHL</i> tumor suppressor and the <i>EZH1</i> histone methyltransferase.Sci Transl Med2017
27058663Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.Cell2016
27329820Integrated genetic and pharmacologic interrogation of rare cancers.Nat Commun2016
27260156Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.Cancer Discov2016
26912360MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Science2016
25535386Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease.Proc Natl Acad Sci U S A2015
26351322Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.Mol Cancer Ther2015
26337082Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Oncotarget2015
25848864The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.Nat Immunol2015
25646658Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA.Assay Drug Dev Technol2015
25548173Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.Proc Natl Acad Sci U S A2015
23584476Genome-wide functional screening identifies CDC37 as a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors.Oncogene2014
25512523Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.Proc Natl Acad Sci U S A2014
24616378Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.J Exp Med2014
24516381The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.PLoS Pathog2014
24476824In vivo discovery of immunotherapy targets in the tumour microenvironment.Nature2014
23288408A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.Cancer Discov2013
24332042SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.Cancer Cell2013
23715154Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.Cancer Discov2013
23770013In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.Cancer Cell2013
23393090(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.Science2013
22896676Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4.Sci Transl Med2012
23245941β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.Cell2012
22863534Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.Cell Stem Cell2012
22901813Cancer vulnerabilities unveiled by genomic loss.Cell2012
21760589Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.Nature2011
21548937A comprehensive platform for highly multiplexed mammalian functional genetic screens.BMC Genomics2011
21746896Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.Proc Natl Acad Sci U S A2011
17114577Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.Genes Dev2006
9919310Genetic variation in the 3' untranslated region of the neurofibromatosis 1 gene: application to unequal allelic expression.Somat Cell Mol Genet1998
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Collaborators

David E Root
Broad Institute of Harvard and MIT
Co-authored papers 38
William C Hahn
Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute
Co-authored papers 17
Barbara A Weir
Janssen Research and Development LLC
Co-authored papers 16
Aviad Tsherniak
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 16
Francisca Vazquez
Broad Institute of MIT and Harvard
Co-authored papers 14
Benjamin L Ebert
Co-authored papers 10
Levi A Garraway
Broad Institute of Harvard and MIT
Co-authored papers 9
Jesse S Boehm
Broad Institute of Harvard and MIT
Co-authored papers 7
Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 7
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 6
Rameen Beroukhim
Co-authored papers 5
Jill P Mesirov
University of California San Diego
Co-authored papers 4
Gregory V Kryukov
Co-authored papers 4
James E Bradner
Co-authored papers 4
Nir Hacohen
Broad Institute of MIT and Harvard
Co-authored papers 4
Charles W M Roberts
Co-authored papers 4
F??tima Al-Shahrour
Spanish National Cancer Research Centre (CNIO)
Co-authored papers 4
Pablo Tamayo
University of California San Diego
Co-authored papers 3
Travis I Zack
Co-authored papers 3
Gabriela Alexe
Dana-Farber Cancer Institute
Co-authored papers 3
Sangeeta N Bhatia
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 3
Sara Howell
Broad Institute of Harvard and MIT
Co-authored papers 3
Federica Piccioni
Co-authored papers 3
John G Doench
Co-authored papers 3
Jun Qi
Dana-Farber Cancer Institute
Co-authored papers 3
Iswar K Hariharan
University of California berkeley
Co-authored papers 2
Stuart L Schreiber
Broad Institute
Co-authored papers 2
Jordi Barretina
Co-authored papers 2
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 2
Matthew Meyerson
Broad Institute
Co-authored papers 2
Release 1.2