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Author Details

Susan S Taylor
University of California
1969
453
100
PMIDPaper TitleJournal TitlePublished Year
36892429An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP-dependent protein kinase A.FEBS Lett2023
37745542The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A.bioRxiv2023
37693538Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop.bioRxiv2023
37551632Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.Biochem J2023
37212165Capturing the domain crosstalk in full length LRRK2 and LRRK2RCKW.Biochem J2023
36892429An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP-dependent protein kinase A.FEBS Lett2023
36764356Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order-Disorder Transition Upon Activation.J Mol Biol2023
37066274Do perineuronal nets stabilize the engram of a synaptic circuit?bioRxiv2023
36993163Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.bioRxiv2023
36859094The "violin model": Looking at community networks for dynamic allostery.J Chem Phys2023
37043829Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors.ACS Chem Biol2023
36855225Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A.IUBMB Life2023
37551632Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.Biochem J2023
37745542The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A.bioRxiv2023
37693538Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop.bioRxiv2023
36993163Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.bioRxiv2023
37212165Capturing the domain crosstalk in full length LRRK2 and LRRK2RCKW.Biochem J2023
37043829Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors.ACS Chem Biol2023
37066274Do perineuronal nets stabilize the engram of a synaptic circuit?bioRxiv2023
36859094The "violin model": Looking at community networks for dynamic allostery.J Chem Phys2023
36855225Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A.IUBMB Life2023
36764356Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order-Disorder Transition Upon Activation.J Mol Biol2023
34330820The Tails of Protein Kinase A.Mol Pharmacol2022
36375071Calculation of centralities in protein kinase A.Proc Natl Acad Sci U S A2022
35905186ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy.Sci Adv2022
36166510Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.Sci Signal2022
36202993A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.Nat Struct Mol Biol2022
34330820The Tails of Protein Kinase A.Mol Pharmacol2022
35042780A tribute to Eddy Fischer (April 6, 1920-August 27, 2021): Passionate biochemist and mentor.Proc Natl Acad Sci U S A2022
35192607LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.PLoS Biol2022
35078976A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.Nat Commun2022
35905186ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy.Sci Adv2022
36202993A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.Nat Struct Mol Biol2022
36166510Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.Sci Signal2022
36375071Calculation of centralities in protein kinase A.Proc Natl Acad Sci U S A2022
35042780A tribute to Eddy Fischer (April 6, 1920-August 27, 2021): Passionate biochemist and mentor.Proc Natl Acad Sci U S A2022
35078976A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.Nat Commun2022
35192607LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.PLoS Biol2022
34224748Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?J Mol Biol2021
33692454Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.Commun Biol2021
34115095PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies.Biochem J2021
33957122From structure to the dynamic regulation of a molecular switch: A journey over 3 decades.J Biol Chem2021
33850054mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.Sci Signal2021
34224748Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?J Mol Biol2021
34006641Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.Proc Natl Acad Sci U S A2021
34088839Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.Proc Natl Acad Sci U S A2021
33824409Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.Commun Biol2021
34663687G<i>α</i>s-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant G<i>α</i>s-PKA Signaling.Pharmacol Rev2021
34370450Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics.Biochemistry2021
33824409Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.Commun Biol2021
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Collaborators

Natarajan Kannan
University of Georgia
Co-authored papers 20
Mark H Ellisman
National Center for Microscopy and Imaging Research, University of California
Co-authored papers 12
Joseph A Adams
University of California San Diego
Co-authored papers 12
David A Johnson
Co-authored papers 11
Roger Y Tsien
University of California
Co-authored papers 11
Alexandra C Newton
Co-authored papers 10
Manjula Darshi
Center for Renal Precision Medicine, University of Texas Health San Antonio
Co-authored papers 8
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University of Texas Southwestern Medical Center
Co-authored papers 7
David A Bernlohr
University of Minnesota-Twin Cities
Co-authored papers 7
James Andrew McCammon
Co-authored papers 6
John D Scott
University of Washington
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Elizabeth A Komives
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Paul A Insel
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Jill Trewhella
The University of Sydney
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National Cancer Institute
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Jack E Dixon
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Gerard Manning
Genentech Inc.
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Jorge Silvio Gutkind
Moores Cancer Center, University of California San Diego
Co-authored papers 4
Lukasz Jaroszewski
University of California Riverside School of Medicine
Co-authored papers 4
Albert J R Heck
Utrecht University
Co-authored papers 3
Heath E Klock
Merck & Co., Inc.
Co-authored papers 3
Marc-Andr?? Elsliger
Joint Center for Structural Genomics
Co-authored papers 3
Linda S Brinen
The Joint Center for Structural Genomics, Stanford University
Co-authored papers 3
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 3
Mitchell D Miller
Rice University
Co-authored papers 3
Daniel McMullan
Genomics Institute of the Novartis Research Foundation
Co-authored papers 3
Peter Kuhn
University of Tubingen
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Release 1.2