Author details

Full Name

Xian Chen

Affiliation

ORCID

Career Start Year

2004

Papers

111

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36538511	Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer.	J Med Chem	2023
37028406	Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease.		2023
37141574	Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins.	J Am Chem Soc	2023
37199584	The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine.		2023
36448571	Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.	J Am Chem Soc	2022
35969644	Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.	PLoS Pathog	2022
35966090	The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease.	Frontiers in Endocrinology	2022
35837138	Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2.	ACS Pharmacol Transl Sci	2022
36286484	Nonlytic Quasi-Enveloped Hepatovirus Release Is Facilitated by pX Protein Interaction with the E3 Ubiquitin Ligase ITCH.	Journal of Virology	2022
36347944	Histone H3 proline 16 hydroxylation regulates mammalian gene expression.	Nat Genet	2022
36197750	Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells.	J Med Chem	2022
35786952	TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors.	J Am Chem Soc	2022
34855399	Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders.	J Med Chem	2021
33644773	Protocol for proteogenomic dissection of intronic splicing enhancer interactome for prediction of individualized cancer prognosis.	STAR Protocols	2021
33854241	Author Correction: AIM2 in regulatory T cells restrains autoimmune diseases.	Nature	2021
34100597	TF-PROTACs Enable Targeted Degradation of Transcription Factors.	J Am Chem Soc	2021
33767427	Multi-omics analyses reveal that HIV-1 alters CD4<sup>+</sup> T cell immunometabolism to fuel virus replication.	Nat Immunol	2021
33505023	AIM2 in regulatory T cells restrains autoimmune diseases.	Nature	2021
34301793	AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.	Cancer Discov	2021
34520194	Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.	J Am Chem Soc	2021
34568836	Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders.	Nat Cancer	2021
32787082	Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.	J Med Chem	2020
31895569	Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.	J Med Chem	2020
31810986	TBK1 Is a Synthetic Lethal Target in Cancer with Loss.	Cancer Discovery	2020
32768436	Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.		2020
33355139	CRL4[DCAF1/VprBP] E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development.	Sci Adv	2020
33236014	Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.	bioRxiv	2020
33284613	Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders.	J Med Chem	2020
31146747	Novel secretome-to-transcriptome integrated or secreto-transcriptomic approach to reveal liquid biopsy biomarkers for predicting individualized prognosis of breast cancer patients.	BMC Medical Genomics	2019
31730343	Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.	J Med Chem	2019
31729379	Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.	Nat Commun	2019
31336272	Multi-omic Dissection of Oncogenically Active Epiproteomes Identifies Drivers of Proliferative and Invasive Breast Tumors.	iScience	2019
30997501	TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.	Nucleic Acids Research	2019
29503206	Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer.	Cell Chemical Biology	2018
30026228	VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.	Science	2018
30446383	RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs.	Immunity	2018
30473739	The effects of nonignorable missing data on label-free mass spectrometry proteomics experiments.	Ann Appl Stat	2018
29894226	Relative and Absolute Quantitation in Mass Spectrometry-Based Proteomics.	Annual Review of Analytical Chemistry	2018
27836980	Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction.	Mol Cell Proteomics	2017
28348404	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts.	Nat Commun	2017
28854366	The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology.	Cell Reports	2017
28490497	Protein composition of the hepatitis A virus quasi-envelope.	Proceedings of the National Academy of Sciences of the United States of America	2017
28440318	Corrigendum: Proteogenomic integration reveals therapeutic targets in breast cancer xenografts.	Nat Commun	2017
29072299	Reversing SKI-SMAD4-mediated suppression is essential for T<sub>H</sub>17 cell differentiation.	Nature	2017
27925692	A Method to Generate and Analyze Modified Myristoylated Proteins.	ChemBioChem	2017
26631509	An Analysis of the Sensitivity of Proteogenomic Mapping of Somatic Mutations and Novel Splicing Events in Cancer.	Mol Cell Proteomics	2016
27113764	The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.	EMBO Reports	2016
27112199	Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation.	Scientific Reports	2016
26867747	Using the CPTAC Assay Portal to Identify and Implement Highly Characterized Targeted Proteomics Assays.	Methods Mol Biol	2016
26728942	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms.	Nature Communications	2016