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Author Details

Shira Albeck
Weizmann Institute of Science
1996
65
31
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36808692Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification.FEBS J2023
37860961The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.Acta Crystallogr D Struct Biol2023
37561584Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice.J Clin Invest2023
37463895Allosteric activation of vinculin by talin.Nat Commun2023
35102291Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.Nat Biotechnol2022
35359497The identification and characterization of an oxalyl-CoA synthetase from grass pea (<i>Lathyrus sativus</i> L.).RSC Chem Biol2022
34787433Evolution of CPEB4 Dynamics Across its Liquid-Liquid Phase Separation Transition.J Phys Chem B2021
33781758Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.J Mol Biol2021
34904830Correction to "Evolution of CPEB4 Dynamics Across Its Liquid-Liquid Phase Separation Transition".J Phys Chem B2021
32369353Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs.J Am Chem Soc2020
31862713Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques.Proc Natl Acad Sci U S A2020
33085658Correction: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.PLoS Comput Biol2020
32500941Highly active rubiscos discovered by systematic interrogation of natural sequence diversity.EMBO J2020
32520539Correction to Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs.J Am Chem Soc2020
30449673Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.Cell Chem Biol2019
31442220Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.PLoS Comput Biol2019
31054266Tracking Conformational Changes in Calmodulin in vitro, in Cell Extract, and in Cells by Electron Paramagnetic Resonance Distance Measurements.Chemphyschem2019
29677494Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.Mol Cell2018
30018322Highly active enzymes by automated combinatorial backbone assembly and sequence design.Nat Commun2018
30250274Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3⿿ÿ resolution.Nat Commun2018
30088929Manipulating the Folding Landscape of a Multidomain Protein.J Phys Chem B2018
30248156Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli.PLoS One2018
30538236Ultrahigh specificity in a network of computationally designed protein-interaction pairs.Nat Commun2018
28973872Principles for computational design of binding antibodies.Proc Natl Acad Sci U S A2017
28099413Communication between viruses guides lysis-lysogeny decisions.Nature2017
27425410Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.Mol Cell2016
25785780AcpM, the meromycolate extension acyl carrier protein of Mycobacterium tuberculosis, is activated by the 4'-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.Biochemistry2015
26382918Sensing Protein Surfaces with Targeted Fluorescent Receptors.Chemistry2015
26398521Sensing Protein Surfaces with Targeted Fluorescent Receptors.Chemistry2015
25930950A Recombinant Collagen-mRNA Platform for Controllable Protein Synthesis.Chembiochem2015
23385743Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.Acta Crystallogr Sect F Struct Biol Cryst Commun2013
23675461Separation, immobilization, and biocatalytic utilization of proteins by a supramolecular membrane.PLoS One2013
23769668Variable internal flexibility characterizes the helical capsid formed by agrobacterium VirE2 protein on single-stranded DNA.Structure2013
22685214Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.Proc Natl Acad Sci U S A2012
21277311Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution.J Mol Biol2011
22169534Cortactin releases the brakes in actin- based motility by enhancing WASP-VCA detachment from Arp2/3 branches.Curr Biol2011
21959261Cyt1Aa toxin: crystal structure reveals implications for its membrane-perforating function.J Mol Biol2011
21738225GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling.EMBO Rep2011
21473635Structure of estradiol metal chelate and estrogen receptor complex: the basis for designing a new class of selective estrogen receptor modulators.J Med Chem2011
21458342A de novo protein binding pair by computational design and directed evolution.Mol Cell2011
20036254Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series.J Mol Biol2010
20691273New trends in protein expression.J Struct Biol2010
20306145Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain.J Struct Funct Genomics2010
19749752Following evolutionary paths to protein-protein interactions with high affinity and selectivity.Nat Struct Mol Biol2009
19694409A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.Biochemistry2009
19733180Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis.J Mol Biol2009
18361457Crystal structure of YagE, a putative DHDPS-like protein from Escherichia coli K12.Proteins2008
18722383The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage.J Mol Biol2008
18571667High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp. israelensis.J Mol Biol2008
18678909Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners.Proc Natl Acad Sci U S A2008
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Collaborators

Weizmann Institute of Science
Co-authored papers 35
Weizmann Institute of Science
Co-authored papers 31
Weizmann Institute of Science
Co-authored papers 21
Weizmann Institute of Science
Co-authored papers 11
Co-authored papers 11
Co-authored papers 6
University of Washington
Co-authored papers 5
Weizmann Institute of Science
Co-authored papers 5
The Weizmann Institute of Science
Co-authored papers 3
Rensselaer Polytechnic Institute
Co-authored papers 2
CNRS, Aix-Marseille Universite
Co-authored papers 2
Weizmann Institute of Science
Co-authored papers 2
Co-authored papers 2
University of Oxford
Co-authored papers 2
Aix Marseille University and CNRS
Co-authored papers 2
Karolinska Institutet, BioClinicum J6
Co-authored papers 2
the Francis Crick Institute
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Center for Genomics and Systems Biology, New York University Abu Dhabi (NYUAD)
Co-authored papers 1
Robert Wood Johnson Medical School, Rutgers University
Co-authored papers 1
Co-authored papers 1
University of Oxford
Co-authored papers 1
Structural Genomics Consortium Karolinska Institute Stockholm Sweden.
Co-authored papers 1
Nankai University
Co-authored papers 1
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 1
Co-authored papers 1
Brookhaven National Laboratory
Co-authored papers 1
Los Alamos National Laboratory
Co-authored papers 1
Co-authored papers 1
University of Science & Technology of China
Co-authored papers 1