Author details

Full Name

John J Fak

Affiliation

ORCID

Career Start Year

1995

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36993710	Genetic mapping identifies Homer1 as a developmental modifier of attention.	bioRxiv	2024
36812347	Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis.	Sci Transl Med	2023
37407548	Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson's disease.		2023
36106631	Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade.	J Clin Invest	2022
34939924	FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons.	eLife	2021
34170927	DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2.	PLoS One	2021
32668112	RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares.	N Engl J Med	2020
31340158	AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke.	Cell Reports	2019
31860442	FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory.	Elife	2019
31805257	A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP Î²-CTFs, Not AÎ².	Neuron	2019
30638744	Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function.	Neuron	2019
31133750	Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk.	Nat Genet	2019
31416668	A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP Î²-CTFs, Not AÎ².	Neuron	2019
29848443	ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity.	Elife	2018
29578408	Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types.	Elife	2018
28147283	Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen.	Cell Reports	2017
28910620	cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.	Neuron	2017
28637692	mA mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.	Genes and Development	2017
28811507	Global mapping of miRNA-target interactions in cattle (Bos taurus).	Sci Rep	2017
29093272	T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy.	JCI insight	2017
26894958	Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain.	Elife	2016
27050522	PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage.	Cell Rep	2016
26962949	A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration.	Cell Host Microbe	2016
27223325	NOVA2-mediated RNA regulation is required for axonal pathfinding during development.	Elife	2016
26684871	Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen.		2015
25768906	Hepatitis C virus RNA functionally sequesters miR-122.	Cell	2015
26404942	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.	Genes Dev	2015
26602609	miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity.	Nat Commun	2015
25103845	TÂ cells targeting a neuronal paraneoplastic antigen mediate tumor rejection and trigger CNS autoimmunity with humoral activation.	European Journal of Immunology	2014
23390586	Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo.	eLife	2013
23359859	NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.	eLife	2013
22998874	Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.	Neuron	2012
22802532	Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.	Genes and Development	2012
21784246	FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.	Cell	2011
20558669	Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls.	Science	2010
20383333	The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells.	PLoS ONE	2010
19509467	Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells.	Journal of Clinical Investigation	2009
19221030	Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.	Proceedings of the National Academy of Sciences of the United States of America	2009
18978773	HITS-CLIP yields genome-wide insights into brain alternative RNA processing.	Nature	2008
15989958	Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development.	Cell	2005
15182175	Nucleotide exchange from the high-affinity ATP-binding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state.	Biochemistry	2004
15340490	Transcriptional control in the segmentation gene network of Drosophila.	PLoS Biol	2004
12403785	Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA.	J Biol Chem	2003
12242434	Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA.	Science	2002
11264585	Conformational stabilization and crystallization of the SecA translocation ATPase from Bacillus subtilis.	Acta Crystallogr D Biol Crystallogr	2001
9405708	Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels of hair cells in the chicken's cochlea.	Proceedings of the National Academy of Sciences of the United States of America	1997
9405709	Hair cell-specific splicing of mRNA for the alpha1D subunit of voltage-gated Ca2+ channels in the chicken's cochlea.	Proceedings of the National Academy of Sciences of the United States of America	1997
7546772	Regulation of rat pulmonary dendritic cell immunostimulatory activity by alveolar epithelial cell-derived granulocyte macrophage colony-stimulating factor.	American Journal of Respiratory Cell and Molecular Biology	1995
7537533	Cloning the rat homolog of the CD28/CTLA-4-ligand B7-1: structural and functional analysis.	International Immunology	1995