Author details

Full Name

Jonathan M Backer

Affiliation

Albert Einstein College of Medicine

ORCID

Career Start Year

1970

Papers

178

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
36920093	Macropinocytosis: mechanisms and regulation.	Biochem J	2023
34990021	PIP<sub>3</sub> abundance overcomes PI3K signaling selectivity in invadopodia.	FEBS Lett	2022
33500475	Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.	Sci Rep	2021
30659094	A single discrete Rab5-binding site in phosphoinositide 3-kinase Î² is required for tumor cell invasion.	J Biol Chem	2019
31409694	PI3KÎ² is selectively required for growth factor-stimulated macropinocytosis.	J Cell Sci	2019
31318314	PI3KÎ² links integrin activation and PI(3,4)P<sub>2</sub> production during invadopodial maturation.	Mol Biol Cell	2019
30601996	PI3KÎ²-A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling.	Endocrinology	2019
29282275	S100A4 regulates macrophage invasion by distinct myosin-dependent and myosin-independent mechanisms.	Mol Biol Cell	2018
29953877	Myosin-IIA heavy chain phosphorylation on S1943 regulates tumor metastasis.	Exp Cell Res	2018
29046393	Rac1-stimulated macropinocytosis enhances GÎ²Î³ activation of PI3KÎ².	Biochem J	2017
29180704	Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.	Nat Commun	2017
26799652	Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).	Autophagy	2016
27531651	Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3KÎ² in myeloid cells.	Sci Signal	2016
27470591	The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34.	Biochem J	2016
27013201	GPCR Signaling Mediates Tumor Metastasis via PI3KÎ².	Cancer Res	2016
25800850	Identification of the Rab5 binding site in p110Î²: assays for PI3KÎ² binding to Rab5.	Methods Mol Biol	2015
26655903	Inactivation of the Class II PI3K-C2Î² Potentiates Insulin Signaling and Sensitivity.	Cell Rep	2015
26475863	Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85Î± Homodimer.	J Biol Chem	2015
26733885	Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models.	Front Physiol	2015
26100075	PI3K-C2Î³ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.	Nat Commun	2015
25825728	Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis.	Proc Natl Acad Sci U S A	2015
24785657	NRBF2 regulates macroautophagy as a component of Vps34 Complex I.	Biochem J	2014
25231351	Suppression of mTORC1 activation in acid-Î±-glucosidase-deficient cells and mice is ameliorated by leucine supplementation.	Am J Physiol Regul Integr Comp Physiol	2014
23434372	Class IA PI3K p110Î² subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation.	Mol Cell	2013
24190998	Molecular determinants of PI3KÎ³-mediated activation downstream of G-protein-coupled receptors (GPCRs).	Proc Natl Acad Sci U S A	2013
23765576	Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases.	Bioessays	2013
23734178	Characterization of a tumor-associated activating mutation of the p110Î² PI 3-kinase.	PLoS One	2013
23411347	Novel approaches to inhibitor design for the p110Î² phosphoinositide 3-kinase.	Trends Pharmacol Sci	2013
21725367	Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.	Oncogene	2012
23211529	G protein-coupled receptor-mediated activation of p110Î² by GÎ²Î³ is required for cellular transformation and invasiveness.	Sci Signal	2012
23328076	PI3KÎ² downstream of GPCRs - crucial partners in oncogenesis.	Oncotarget	2012
22128329	Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2Î².	Proc Natl Acad Sci U S A	2011
22024166	Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway.	J Cell Biol	2011
20053679	The late endosome is essential for mTORC1 signaling.	Mol Biol Cell	2010
21321382	A beta version of life: p110Î² takes center stage.	Oncotarget	2010
21115805	Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes.	J Cell Biol	2010
21030680	A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.	Proc Natl Acad Sci U S A	2010
20544340	The regulation of class IA PI 3-kinases by inter-subunit interactions.	Curr Top Microbiol Immunol	2010
20504279	New methods for capturing the mystery lipid, PtdIns5P.	Biochem J	2010
20131869	The structure of p85ni in class IA phosphoinositide 3-kinase exhibits interdomain disorder.	Biochemistry	2010
20436274	mTORC1 signals from late endosomes: taking a TOR of the endocytic system.	Cell Cycle	2010
18957027	hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells.	Biochem J	2009
19915146	Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.	Proc Natl Acad Sci U S A	2009
19903845	Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.	Cancer Res	2009
19962665	Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.	Cancer Cell	2009
19587117	The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells.	Mol Biol Cell	2009
19270693	Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex.	Nat Cell Biol	2009
18362183	WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells.	J Cell Biol	2008
18780892	Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.	Sci Signal	2008
18474623	The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.	J Cell Biol	2008

1 - 50 of 178

Ganna Panasyuk

Institut Necker-Enfants Malades (INEM)

Career Start Year 2002

Number of shared co-authors 2

Rachel Toth

University of Dundee

Career Start Year 1999

Number of shared co-authors 4

Lawrence E Goldfinger

Cardeza Foundation for Hematologic Research, Thomas Jefferson University

Career Start Year 1998

Number of shared co-authors 1

Ian Pass

Cancer Center, Sanford Burnham Prebys Medical Discovery Institute

Career Start Year 1998

Number of shared co-authors 1

Ashok K Pullikuth

Wake Forest University School of Medicine

Career Start Year 1997

Number of shared co-authors 0

Jiefei Tong

Hospital for Sick Children

Career Start Year 1993

Number of shared co-authors 0

Karen H Martin

West Virginia University Cancer Institute, West Virginia University

Career Start Year 1993

Number of shared co-authors 0

Dario R Alessi

University of Dundee

Career Start Year 1992

Number of shared co-authors 1

Ailan Guo

College of Animal Medicine, Xinjiang Agricultural University

Career Start Year 1992

Number of shared co-authors 1

Stephan M Feller

Institute of Molecular Medicine, Martin-Luther-University of Halle-Wittenberg

Career Start Year 1989

Number of shared co-authors 2

Rainer Pepperkok

Translational Lung Research Center Heidelberg, German Center for Lung Research

Career Start Year 1988

Number of shared co-authors 1

David A Eberhard

Lineberger Comprehensive Cancer Center, University of North Carolina

Career Start Year 1987

Number of shared co-authors 1

John Rush

Cell Signaling Technology Inc.

Career Start Year 1987

Number of shared co-authors 1

Michael F Moran

Hospital for Sick Children, University of Toronto

Career Start Year 1985

Number of shared co-authors 0

Jill Meisenhelder

Salk Institute

Career Start Year 1984

Number of shared co-authors 3

Jorge Silvio Gutkind

Moores Cancer Center, University of California San Diego

Career Start Year 1984

Number of shared co-authors 4

James R Woodgett

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital

Career Start Year 1982

Number of shared co-authors 2

Nicholas K Tonks

University of Washington

Career Start Year 1982

Number of shared co-authors 0

Sylvain Meloche

Institute for Research in Immunology and Cancer

Career Start Year 1982

Number of shared co-authors 2

Donald L Durden

Atrium Health-Levine Cancer Institute

Career Start Year 1979

Number of shared co-authors 1

Rohan D Teasdale

The University of Queensland

Career Start Year 1979

Number of shared co-authors 0

Jonathan A Pachter

Laufer Center for Physical and Quantitative Biology, Stony Brook University

Career Start Year 1979

Number of shared co-authors 0

David W Andrews

Sunnybrook Research Institute, University of Toronto

Career Start Year 1978

Number of shared co-authors 6

Sara A Courtneidge

Oregon Health & Science University

Career Start Year 1977

Number of shared co-authors 1

Ravi Iyengar

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai

Career Start Year 1976

Number of shared co-authors 3

Frank McCormick

Frederick National Laboratory for Cancer Research

Career Start Year 1975

Number of shared co-authors 5

Ira Mellman

Genentech Inc.

Career Start Year 1974

Number of shared co-authors 0

Karin D Rodland

Oregon Health and Science University

Career Start Year 1973

Number of shared co-authors 3

Jack E Dixon

University of California

Career Start Year 1972

Number of shared co-authors 2

Tony Hunter

Salk Institute for Biological Studies

Career Start Year 1968

Number of shared co-authors 4

row(s) 1 - 30 of 30

Anne R Bresnick

Albert Einstein College of Medicine

Co-authored papers 18

Haiyan Wu

First Affiliated Hospital, Sun Yat-sen University

Co-authored papers 14

Jaclyn LoPiccolo

Dana-Farber Cancer Institute

Co-authored papers 3

Mousumi Ghosh

Co-authored papers 2

Lucy M Collinson

Co-authored papers 2

Brian T Chait

The Rockefeller University

Co-authored papers 2

Lewis C Cantley

Co-authored papers 2

Andras Fiser

Albert Einstein College of Medicine

Co-authored papers 1

Prerna Dua

Louisiana Tech University

Co-authored papers 1

Derrick Gibbings

University of Ottawa

Co-authored papers 1

Ekihiro Seki

Co-authored papers 1

Haim J Wolfson

Tel Aviv University

Co-authored papers 1

Ezra E W Cohen

university of california san diego Health System

Co-authored papers 1

Nikolai Slavov

and Barnett Institute, Northeastern University

Co-authored papers 1

Laura Caberlotto

The Microsoft Research University of Trento

Co-authored papers 1

Juan Fueyo

The University of Texas M.D. Anderson Cancer Center

Co-authored papers 1

Nikolai V Gorbunov

Armed Forces Radiobiology Research Institute

Co-authored papers 1

J. Wade Harper

Harvard Medical School

Co-authored papers 1

Jan Paul Medema

Oncode Institute

Co-authored papers 1

David M Sabatini

Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology

Co-authored papers 1

Michael Brenowitz

Albert Einstein College of Medicine

Co-authored papers 1

Susan M Domchek

Co-authored papers 1

Arianna L Kim

Co-authored papers 1

Carlos L??pez-Ot??n

Instituto Universitario de Oncologia, Universidad de Oviedo

Co-authored papers 1

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 1

David Sulzer

New York State Psychiatric Institute, Research Foundation for Mental Hygiene

Co-authored papers 1

Ernst J Wolvetang

Australian Institute for Bioengineering and Nanotechnology, University of Queensland

Co-authored papers 1

Manuela Iezzi

Co-authored papers 1

Manish K Aghi

University of California san francisco

Co-authored papers 1

Hirotaka Watada

Co-authored papers 1

1 - 30

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