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Author Details

Matthew B Boxer
2005
55
28
PMIDPaper TitleJournal TitlePublished Year
36914816SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.Nat Cancer2023
37683456Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.Biochem Biophys Res Commun2023
34491744Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.J Med Chem2021
33822623Discovery and Optimization of 2<i>H</i>-1λ<sup>2</sup>-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.J Med Chem2021
34408078The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.Sci Transl Med2021
32371575EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.Mol Cancer Ther2020
30806949Discovery of novel inhibitors of human galactokinase by virtual screening.J Comput Aided Mol Des2019
32184968Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.ACS Med Chem Lett2019
30979745High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma.Clin Cancer Res2019
29555419Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.Bioorg Med Chem2018
30648156Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.ACS Cent Sci2018
29207616PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.Oncotarget2017
28986582Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.Sci Rep2017
29141225A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma.Cell Rep2017
27552339Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors.ACS Chem Biol2016
27110680A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.Nat Chem Biol2016
27434767Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.Nat Chem Biol2016
26838815Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.Nat Commun2016
27428418A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics.EBioMedicine2016
27238019Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery.Cell2016
27482083Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.Proc Natl Acad Sci U S A2016
27458230Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.Antimicrob Agents Chemother2016
27804975Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.Nat Commun2016
27681596Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.J Biol Chem2016
26481663PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.Mol Cell2015
25553891Structure activity relationships of human galactokinase inhibitors.Bioorg Med Chem Lett2015
25653139Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.Nat Commun2015
25896324Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.Nature2015
25940539Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer.Oncotarget2015
25068984GALK inhibitors for classic galactosemia.Future Medicinal Chemistry2014
24418991Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.Leukemia2014
24469833High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.Proc Natl Acad Sci U S A2014
24668804Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.J Biol Chem2014
24699711A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.Nat Commun2014
24900769Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.ACS Med Chem Lett2013
23850693Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.Biochem Biophys Res Commun2013
23273517Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.Bioorg Med Chem Lett2013
23326584A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.PLoS One2013
22906073A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.Biochem J2012
22922757Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.Nat Chem Biol2012
219585452-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.Bioorg Med Chem Lett2011
21291394Chiral kinase inhibitors.Curr Top Med Chem2011
22052977Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.Science2011
21721528Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.J Med Chem2011
20229566A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety.ChemMedChem2010
21516235Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction.Tetrahedron Lett2010
20451379Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.Bioorg Med Chem Lett2010
20017496Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.J Med Chem2010
18181637Super silyl group for a sequential diastereoselective aldol-polyhalomethyllithium addition reaction.Organic Letters2008
18193878Ketone super silyl enol ethers in sequential reactions: diastereoselective generation of tertiary carbinols in one pot.Journal of the American Chemical Society2008
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Wellcome Sanger Institute
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University of Chicago
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Barcelona Institute of Science and Technology, Spain Universitat Pompeu Fabra
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