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Author Details

Jonathan S Weissman
Whitehead Institute for Biomedical Research
1991
274
127
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36711738A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.bioRxiv2023
37803001Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq.Nat Commun2023
37645817Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.bioRxiv2023
36993685Comparative landscape of genetic dependencies in human and chimpanzee stem cells.bioRxiv2023
37218462Coupled protein quality control during nonsense-mediated mRNA decay.J Cell Sci2023
37343560Comparative landscape of genetic dependencies in human and chimpanzee stem cells.Cell2023
37144468Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.Nucleic Acids Res2023
34844857The dark proteome: translation from noncanonical open reading frames.Trends Cell Biol2022
35831657Standardized annotation of translated open reading frames.Nat Biotechnol2022
35668323Variant to function mapping at single-cell resolution through network propagation.Nat Biotechnol2022
35830852A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.Cell Chem Biol2022
35523183Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution.Cell2022
35688146Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.Cell2022
36576240Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.Elife2022
36037385Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication.Proc Natl Acad Sci U S A2022
36381608Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells.Cell Genom2022
36264797MTCH2 is a mitochondrial outer membrane protein insertase.Science2022
36227997Cellular barcoding to decipher clonal dynamics in disease.Science2022
35879364Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.Nat Biotechnol2022
36282590GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.JCI Insight2022
35118467Variant to function mapping at single-cell resolution through network propagation.bioRxiv2022
35271311OpenCell: Endogenous tagging for the cartography of human cellular organization.Science2022
35027731BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.Nat Cell Biol2022
35020435Peroxisome function relies on organelle-associated mRNA translation.Sci Adv2022
34697476Functional single-cell genomics of human cytomegalovirus infection.Nat Biotechnol2022
33326085Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.Methods Mol Biol2021
33545038Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.Cell2021
33904395CRISPR-based functional genomics in human dendritic cells.Elife2021
33838111Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.Cell2021
33501440BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.bioRxiv2021
33691096Regulation of translation by methylation multiplicity of 18S rRNA.Cell Rep2021
34437836Structured elements drive extensive circular RNA translation.Mol Cell2021
34672952Mapping the genetic landscape of DNA double-strand break repair.Cell2021
34653350Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.Cell2021
34414886An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.Elife2021
34183861Efficient Câ¿¢G-to-Gâ¿¢C base editors developed using CRISPRi screens, target-library analysis, and machine learning.Nat Biotechnol2021
34034859Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.Elife2021
33465779High-content imaging-based pooled CRISPR screens in mammalian cells.J Cell Biol2021
33451982A CRISPR/Cas9-Engineered <i>ARID1A</i>-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation.Cancer Discov2021
32290857Inference of single-cell phylogenies from lineage tracing data using Cassiopeia.Genome Biol2020
31932729Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.Nat Biotechnol2020
31919191The microtubule regulator <i>ringer</i> functions downstream from the RNA repair/splicing pathway to promote axon regeneration.Genes Dev2020
33080209Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.Cell Syst2020
32857977Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.Curr Biol2020
32822576Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.Cell2020
32821821Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.Sci Adv2020
32619469Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.Mol Cell2020
32139545Pervasive functional translation of noncanonical human open reading frames.Science2020
30846318Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.Mol Cell2019
30037969Ribosome Profiling: Global Views of Translation.Cold Spring Harb Perspect Biol2019
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Collaborators

Luke A Gilbert
Arc Institute
Co-authored papers 26
Sean R Collins
University of California davis
Co-authored papers 25
Martin Kampmann
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 25
Max A Horlbeck
Broad Institute of MIT and Harvard
Co-authored papers 24
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 21
Maya Schuldiner
The Weizmann Institute of Science
Co-authored papers 16
Michael C Bassik
Stanford University Medical Center
Co-authored papers 13
Peter Walter
University of California san francisco
Co-authored papers 12
Carol A Gross
University of California san francisco
Co-authored papers 11
Lei S Qi
Stanford University
Co-authored papers 10
Aviv Regev
Broad Institute of MIT and Harvard
Co-authored papers 8
Vladimir Denic
Harvard University
Co-authored papers 8
Manuel D Leonetti
University of California, USA Howard Hughes Medical Institute san francisco
Co-authored papers 8
Jacqueline E Villalta
University of California san francisco
Co-authored papers 7
Noah Stern
Weizmann Institute of Science
Co-authored papers 6
Michael Shales
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 6
Erin K O'Shea
Howard Hughes Medical Institute
Co-authored papers 6
James A Wells
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 6
Wendell A Lim
University of California san francisco
Co-authored papers 5
Siyuan John Liu
University of California San Francisco.
Co-authored papers 5
David K Breslow
Yale University
Co-authored papers 5
Onn Brandman
Stanford University
Co-authored papers 5
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 5
Adam Frost
University of California San Francisco
Co-authored papers 5
Bruce R Conklin
Gladstone Institutes
Co-authored papers 5
Jacob Stewart-Ornstein
Hillman Cancer Center, University of Pittsburgh School of Medicine
Co-authored papers 5
Daniel A Lim
University of California san francisco
Co-authored papers 5
Reuben A Saunders
University of California San Francisco
Co-authored papers 5
Sourav Bandyopadhyay
University of California San Francisco
Co-authored papers 4
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 4
Release 1.2