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Author Details

Duncan Sproul
Institute of Genetics and Cancer, University of Edinburgh
2004
37
24
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37336879Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair.Nat Commun2023
37782664Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin that reflect nucleosome organisation.PLoS Genet2023
37380644Author Correction: Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair.Nat Commun2023
35078341Cluster mean-field theory accurately predicts statistical properties of large-scale DNA methylation patterns.J R Soc Interface2022
36253871Local CpG density affects the trajectory and variance of age-associated DNA methylation changes.Genome Biol2022
35074757In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma.Cancer Res2022
31796892An epigenetic predictor of death captures multi-modal measures of brain health.Mol Psychiatry2021
33514701De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.Nat Commun2021
33857425Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.Cell2021
32585002Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes.Nucleic Acids Res2020
33230297cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing.Nat Genet2020
32699299Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation.Nat Commun2020
30478443Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.Nat Genet2019
31043600Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.Nat Commun2019
30918249Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.Nat Commun2019
29025912Variable outcome and methylation status according to <i>CEBPA</i> mutant type in double-mutated acute myeloid leukemia patients and the possible implications for treatment.Haematologica2018
30348214Genotype effects contribute to variation in longitudinal methylome patterns in older people.Genome Med2018
28465359Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators.Genes Dev2017
28351383Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.Genome Biol2017
25531315FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer.Oncogene2015
26235388Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer.Genome Biol2015
24277643DNA methylation reprogramming in cancer: does it act by re-configuring the binding landscape of Polycomb repressive complexes?Bioessays2014
25187560Transcription factor binding predicts histone modifications in human cell lines.Proc Natl Acad Sci U S A2014
23341493Genomic insights into cancer-associated aberrant CpG island hypermethylation.Brief Funct Genomics2013
23703216Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer.Nucleic Acids Res2013
22106369Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.Genome Res2012
23034185Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns.Genome Biol2012
22689141Targeting of Rac GTPases blocks the spread of intact human breast cancer.Oncotarget2012
22514623Diversity of matriptase expression level and function in breast cancer.PLoS One2012
22323521Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.Nucleic Acids Res2012
21368160Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.Proc Natl Acad Sci U S A2011
21859834Modelling genetic and clinical heterogeneity in epithelial ovarian cancers.Carcinogenesis2011
20471950Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.Mol Cell2010
21070966Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures.Mol Cell2010
18369458Recruitment to the nuclear periphery can alter expression of genes in human cells.PLoS Genet2008
16160692The role of chromatin structure in regulating the expression of clustered genes.Nat Rev Genet2005
14759252Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes.Genome Biol2004
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Collaborators

Richard R Meehan
Institute of Genetics and Molecular Medicine, University of Edinburgh
Co-authored papers 9
Riccardo E Marioni
Institute of Genetics and Cancer, University of Edinburgh
Co-authored papers 4
Peter M Visscher
Co-authored papers 2
Caroline Hayward
Co-authored papers 2
Andrew P Jackson
Institute of Genetics and Cancer, University of Edinburgh
Co-authored papers 2
Graeme R Grimes
Co-authored papers 2
Pau Navarro
Co-authored papers 2
James F Wilson
Co-authored papers 2
John P Thomson
MRC Institute of Genetics and Cancer, University of Edinburgh
Co-authored papers 2
Claire Palles
Institute of Cancer and Genomic Sciences, University of Birmingham
Co-authored papers 2
Paul Bertone
Co-authored papers 2
Martin S Taylor
Institute of Genetics and Cancer, University of Edinburgh
Co-authored papers 1
Scott Waddell
Co-authored papers 1
Neil A Robertson
Beatson Institute for Cancer Research and the University of Glasgow
Co-authored papers 1
Richard A Miller
University of Michigan School of Medicine ann arbor
Co-authored papers 1
Clare V Logan
Co-authored papers 1
David A D Parry
Co-authored papers 1
Alison D Murray
Co-authored papers 1
Juri Rappsilber
Institute for Biotechnology, Technical University Berlin
Co-authored papers 1
Alison Meynert
Institute of Genetics and Cancer, University of Edinburgh
Co-authored papers 1
Holly M Brown-Borg
University of North Dakota
Co-authored papers 1
Jan Rehwinkel
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Co-authored papers 1
Sebastian Brandner
UCL Queen Square Institute of Neurology
Co-authored papers 1
John J Cole
College of Medicine, University of Glasgow
Co-authored papers 1
Bauke Ylstra
Cancer Center Amsterdam, Vrije Universiteit Amsterdam
Co-authored papers 1
Simon A Gayther
Cedars-Sinai Medical Center
Co-authored papers 1
Elizabeth Benjamin
Grady Memorial Hospital
Co-authored papers 1
Claire Brock
Beatson Institute for Cancer Research and University of Glasgow
Co-authored papers 1
Peter D Adams
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Lee Murphy
Edinburgh Clinical Research Facility, University of Edinburgh
Co-authored papers 1
Release 1.2