Author details

Full Name

David W H Riches

Affiliation

ORCID

Career Start Year

1980

Papers

132

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36752201	Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis.		2023
37768734	Regulation of epithelial transitional states in murine and human pulmonary fibrosis.		2023
36444345	Engineering Hybrid-Hydrogels Comprised of Healthy or Diseased Decellularized Extracellular Matrix to Study Pulmonary Fibrosis.	Cellular and Molecular Bioengineering	2022
36366982	Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models.	Biomaterials Science	2022
35679511	New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.	Am J Respir Cell Mol Biol	2022
33406369	Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice.	American Journal of Respiratory Cell and Molecular Biology	2021
33290280	Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis.	JCI insight	2020
32491951	Protein tyrosine phosphatase-Î± amplifies transforming growth factor-Î²-dependent profibrotic signaling in lung fibroblasts.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2020
31056475	FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury.	Stem Cell Reports	2019
31285305	Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases.	European Respiratory Journal	2019
29727583	Protein Tyrosine Phosphatase-N13 Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis.	American Journal of Respiratory and Critical Care Medicine	2018
29987779	Overview of Innate Lung Immunity and Inflammation.	Methods in Molecular Biology	2018
29543042	Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2018
28618253	Hypoxia-Inducible Factor 1Î± Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.	American Journal of Pathology	2017
26442449	Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs.	Nat Commun	2015
25830827	Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung.	Ann Am Thorac Soc	2015
25687558	ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis.	American Journal of Pathology	2015
24650563	Protein tyrosine phosphatase Î± mediates profibrotic signaling in lung fibroblasts through TGF-Î² responsiveness.	American Journal of Pathology	2014
24316673	Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.	Nature Cell Biology	2014
24325577	Tumor necrosis factor-Î± accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages.	American Journal of Respiratory Cell and Molecular Biology	2014
23520315	The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance.	Eur Respir J	2014
23529475	Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice.	Arthritis Rheum	2013
24012416	Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes.	Immunity	2013
23154082	Obesity impairs apoptotic cell clearance in asthma.	Journal of Allergy and Clinical Immunology	2013
22185348	A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice.	Exp Lung Res	2012
22301548	Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1.	Journal of Immunology	2012
22582160	Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs.	American Journal of Respiratory and Critical Care Medicine	2012
22472773	Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax.	Mucosal Immunology	2012
22312129	Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP.	Journal of Immunology	2012
23186914	Local delivery of biodegradable pirfenidone nanoparticles ameliorates bleomycin-induced pulmonary fibrosis in mice.	Nanotechnology	2012
21799120	Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-Î² release in lung epithelial cells.	American Journal of Respiratory Cell and Molecular Biology	2012
21871427	Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.	American Journal of Pathology	2011
21632719	Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis.	Journal of Immunology	2011
21587154	Non-surgical intratracheal instillation of mice with analysis of lungs and lung draining lymph nodes by flow cytometry.	Journal of Visualized Experiments	2011
21807741	Lung dendritic cells at the innate-adaptive immune interface.	Journal of Leukocyte Biology	2011
21743030	Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis.	Am J Physiol Lung Cell Mol Physiol	2011
20671265	Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling.	American Journal of Pathology	2010
19372246	Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis.	American Journal of Respiratory Cell and Molecular Biology	2010
20704259	TNF receptor-1 (TNF-R1) ubiquitous scaffolding and signaling protein interacts with TNF-R1 and TRAF2 via an N-terminal docking interface.	Biochemistry	2010
20887783	Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress.	Free Radical Biology and Medicine	2010
20805415	Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-Î³ in a nitric oxide-dependent manner.	Journal of Immunology	2010
20693431	PPARÎ³ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease.	Blood	2010
20458742	TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.	Journal of Cellular Physiology	2010
18952895	Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.	Blood	2009
19633071	Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2009
20044622	Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice.	Anticancer Research	2009
19834007	Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways.	Circulation Research	2009
18774390	Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages.	J Allergy Clin Immunol	2008
18403319	Symposium: Thomas L. Petty Aspen Lung Conference: lung injury and repair. Introduction and perspective.		2008
18218994	Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways.	American Journal of Respiratory Cell and Molecular Biology	2008