Author details

Full Name

Edward G Lakatta

Affiliation

ORCID

Career Start Year

1971

Papers

733

H Index

136

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37527539	Echocardiographic heart ageing patterns predict cardiovascular and non-cardiovascular events and reflect biological age: the SardiNIA study.	Eur J Prev Cardiol	2024
36845078	Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs.	Nat Aging	2023
35790659	Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices.	GeroScience	2023
37920273	Transcriptome of Left Ventricle and Sinoatrial Node in Young and Old C57 Mice.		2023
37737772	Enhanced Myocardial Adenylyl CyclaseÂ Activity Alters Heart-Brain Communication.		2023
37790465	Cardiomyocyte-specific adenylyl cyclase type-8 overexpression induces activation of RelA together with myocardial and systemic inflammation.		2023
36520341	Dilated hypertrophic phenotype of the carotid artery is associated with accelerated age-associated central arterial stiffening.	Geroscience	2023
37084120	cAMP signaling affects age-associated deterioration of pacemaker beating interval dynamics.		2023
36821717	Photobiomodulation therapy mitigates cardiovascular aging and improves survival.		2023
37122227	What makes the sinoatrial node tick? A question not for the faint of heart.		2023
36741836	A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan.	Front Cardiovasc Med	2023
37301747	Silencing of Gene Mimics Effect of Aging and Sensitizes Rat Vascular Smooth Muscle Cells to Cardiotonic Steroids: Impact on Fibrosis and Salt Sensitivity.		2023
37097759	DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice.	J Clin Invest	2023
35253449	Ankle-Brachial Index and Energy Production in People Without Peripheral Artery Disease: The BLSA.	J Am Heart Assoc	2022
36182566	The Heart's Pacemaker Mimics Brain Cytoarchitecture and Function: Novel Interstitial Cells Expose Complexity of the SAN.	JACC: Clinical Electrophysiology	2022
36359893	Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome.	Cells	2022
35759167	Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice.	Geroscience	2022
35574456	Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue.	Frontiers in Physiology	2022
36002468	Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study.	Sci Rep	2022
35562955	Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats.	International Journal of Molecular Sciences	2022
36000422	Inflammatory Role of Milk Fat Globule-Epidermal Growth Factor VIII in Age-Associated Arterial Remodeling.	J Am Heart Assoc	2022
36515265	A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8.	Elife	2022
36505046	Adenosine reduces sinoatrial node cell action potential firing rate by uncoupling its membrane and calcium clocks.		2022
36614028	Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via Inhibition of Discoidin Domain Receptor 2.	Int J Mol Sci	2022
34440893	Î²-Adrenergic Stimulation Synchronizes a Broad Spectrum of Action Potential Firing Rates of Cardiac Pacemaker Cells toward a Higher Population Average.	Cells	2021
33537555	Aging- and gender-related modulation of RAAS: potential implications in COVID-19 disease.		2021
33897445	cAMP-Dependent Signaling Restores AP Firing in Dormant SA Node Cells via Enhancement of Surface Membrane Currents and Calcium Coupling.	Front Physiol	2021
34001812	Association of central arterial stiffness with hippocampal blood flow and N-acetyl aspartate concentration in hypertensive adult Dahl salt sensitive rats.	Journal of Hypertension	2021
33785600	Transcriptional regulation of intermolecular Ca signaling in hibernating ground squirrel cardiomyocytes: The myocardin-junctophilin axis.	Proceedings of the National Academy of Sciences of the United States of America	2021
33465513	Heartbeat music.	Heart Rhythm	2021
34216536	Alterations in mitochondrial dynamics with age-related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility.	Aging Cell	2021
33462706	Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study.	Geroscience	2021
33933406	Self-Similar Synchronization of Calcium and Membrane Potential Transitions During ActionÂ Potential Cycles Predict Heart Rate Across Species.	JACC: Clinical Electrophysiology	2021
33876723	A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice.	Elife	2021
33598853	Longitudinal uncoupling of the heart and arteries with aging in a community-dwelling population.	Geroscience	2021
33499200	Carotid Beta Stiffness Association with Thyroid Function.	J Clin Med	2021
34305930	Auto-Antibody Production During Experimental Atherosclerosis in <i>ApoE<sup>-/-</sup></i> Mice.	Front Immunol	2021
33398019	Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan.	npj Aging and Mechanisms of Disease	2021
34566668	Ca and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation.	Frontiers in Physiology	2021
34502259	Discoidin Domain Receptor 2 Regulates AT1R Expression in Angiotensin II-Stimulated Cardiac Fibroblasts via Fibronectin-Dependent Integrin-Î²1 Signaling.	Int J Mol Sci	2021
34445119	Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond.	International Journal of Molecular Sciences	2021
30704792	Aging, MicroRNAs, and Heart Failure.	Current Problems in Cardiology	2020
32413333	Disulfiram Treatment Normalizes Body Weight in Obese Mice.	Cell Metab	2020
31896304	Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction.	Circ Res	2020
32242886	The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science.	JAMA Cardiology	2020
31884052	Impact of Stiffer Arteries on the Response to Antihypertensive Treatment: A Longitudinal Study of the SardiNIA Cohort.	J Am Med Dir Assoc	2020
31776883	Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice.	Geroscience	2020
32439900	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.	Nat Commun	2020
32819526	Synchronized Cardiac Impulses Emerge From Heterogeneous Local Calcium Signals Within and Among Cells of Pacemaker Tissue.	JACC: Clinical Electrophysiology	2020
33164652	Sex Differences in Longitudinal Determinants of Carotid Intima Medial Thickening With Aging in a Community-Dwelling Population: The Baltimore Longitudinal Study on Aging.	J Am Heart Assoc	2020