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Author Details

Christophe Romier
Institut de Genetique et de Biologie Moleculaire et Cellulaire
1993
92
35
PMIDPaper TitleJournal TitlePublished Year
36255625Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras.Methods Mol Biol2023
37902787Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.J Med Chem2023
36853683In cellulo and in vivo assays for compound testing against Trypanosoma cruzi.STAR Protoc2023
36250286Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages.ChemMedChem2023
35306288Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.Eur J Med Chem2022
35608330First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.Chembiochem2022
35496799Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in <i>Trypanosoma cruzi</i>.STAR Protoc2022
36449385Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties.J Med Chem2022
35983937Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni.ChemMedChem2022
35886887Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.Int J Mol Sci2022
34057470The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.Nucleic Acids Res2021
33741961Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.Nat Commun2021
33925246Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of <i>Schistosoma mansoni</i> Histone Deacetylase 8 (<i>sm</i>HDAC8) Inhibitors.Molecules2021
35008795Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.Int J Mol Sci2021
34936867Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.Cell Rep2021
34392190Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.Eur J Med Chem2021
32497960Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1.Eur J Med Chem2020
31816172Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.ChemMedChem2020
33357372La Société de Biologie de Strasbourg⿿: 100 ans au service de la science et de la société.Biol Aujourdhui2020
30645113Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.J Med Chem2019
31682411One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.Biochemistry2019
31496251Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from <i>Schistosoma mansoni</i> (<i>Sm</i>Sirt2).J Med Chem2019
29685969Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity.Philos Trans R Soc Lond B Biol Sci2018
29806110Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.ChemMedChem2018
30092367Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.Eur J Med Chem2018
30347148Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.J Med Chem2018
29498707A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.Molecules2018
28574690Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.J Med Chem2017
28406899Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.PLoS Negl Trop Dis2017
29190092Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.J Med Chem2017
28537315Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.Org Biomol Chem2017
28639720Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.Arch Pharm (Weinheim)2017
28581289Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.J Med Chem2017
28682233[History of the Strasbourg Society of Biology].Biol Aujourdhui2017
26974126Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.Nat Struct Mol Biol2016
28327287Combattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni.Biol Aujourdhui2016
26653328Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.J Med Chem2016
27165318Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput.Adv Exp Med Biol2016
27246211Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.Methods Mol Biol2016
26937828Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.J Med Chem2016
25325257Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.J Biomol Screen2015
26595183Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors.J Mol Graph Model2015
26013035HDAC8: a multifaceted target for therapeutic interventions.Trends Pharmacol Sci2015
25996070Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.Future Med Chem2015
25996069Schistosome sirtuins as drug targets.Future Med Chem2015
25502194Characterization and production of protein complexes by co-expression in Escherichia coli.Methods Mol Biol2015
24234454Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly.Nucleic Acids Res2014
25462986Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.Bioorg Chem2014
25209997TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.Elife2014
25243797Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.J Chem Inf Model2014
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Collaborators

Laboratory IGBMC (Institute of Genetics and of Molecular and Cellular Biology)
Co-authored papers 12
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 3
Universita` degli Studi di Milano
Co-authored papers 3
Weizmann Institute of Science
Co-authored papers 2
CNRS, Aix-Marseille Universite
Co-authored papers 2
Co-authored papers 1
Universita degli Studi di Milano
Co-authored papers 1
Global Phasing Ltd
Co-authored papers 1
and Clinical Immunology, Heinrich Heine University, University Hospital Dusseldorf
Co-authored papers 1
Universita di Torino
Co-authored papers 1
Co-authored papers 1
Weizmann Institute of Science
Co-authored papers 1
Co-authored papers 1
Weizmann Institute of Science
Co-authored papers 1
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
Weizmann Institute of Science
Co-authored papers 1
Aix Marseille University and CNRS
Co-authored papers 1
Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC)
Co-authored papers 1
Universita degli Studi di Milano
Co-authored papers 1
University of Milano
Co-authored papers 1
German Cancer Research Center (DKFZ)
Co-authored papers 1
J. David Gladstone Institutes
Co-authored papers 1
Helmholtz Centre for Infection Research
Co-authored papers 1
University of Oxford
Co-authored papers 1
Istituto di Ricerche Farmacologiche Mario Negri IRCCS
Co-authored papers 1
University of Milano
Co-authored papers 1