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Author Details

Mehdi Bouhaddou
J. David Gladstone Institutes
2014
42
20
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36692000Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms.Elife2023
37758692Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.Nat Commun2023
37738983Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.Cell Host Microbe2023
37738970SARS-CoV-2 variants evolve convergent strategies to remodel the host response.Cell2023
37938000Hepatitis C virus infects and perturbs liver stem cells.mBio2023
37291385Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.Nat Immunol2023
37213254Current proteomics methods applicable to dissecting the DNA damage response.NAR Cancer2023
37204043Network modeling suggests HIV infection phenocopies PI3K-AKT pathway mutations to enhance HPV-associated cervical cancer.Mol Omics2023
35332335Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35729113A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling.Nat Commun2022
35365639A functional map of HIV-host interactions in primary human T cells.Nat Commun2022
36549272How can systems approaches help us understand and treat infectious disease?Cell Syst2022
36316338Network inference from perturbation time course data.NPJ Syst Biol Appl2022
35189161Leveraging modeling and simulation to optimize the therapeutic window for epigenetic modifier drugs.Pharmacol Ther2022
35012962Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.Life Sci Alliance2022
34942634Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35150638Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.Cell Host Microbe2022
33333024Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.Cell2021
33495306Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.Science2021
34591612A protein interaction landscape of breast cancer.Science2021
34546978Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer.JCI Insight2021
34591642A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.Science2021
34075384Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.medRxiv2021
34127972Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.bioRxiv2021
34013269CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.bioRxiv2021
34031651CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.Res Sq2021
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
31729169Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer.Clin Transl Sci2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
32995787Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses.bioRxiv2020
32645325The Global Phosphorylation Landscape of SARS-CoV-2 Infection.Cell2020
32444466The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2.Cancer Discov2020
31288129Mapping the protein-protein and genetic interactions of cancer to guide precision medicine.Curr Opin Genet Dev2019
28950062Integrating Transcriptomic Data with Mechanistic Systems Pharmacology Models for Virtual Drug Combination Trials.ACS Chem Neurosci2018
30054510Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array.Sci Rep2018
30339749Fluorescence Multiplexing with Spectral Imaging and Combinatorics.ACS Comb Sci2018
29579036A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens.PLoS Comput Biol2018
29342193Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma.PLoS One2018
29116112A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries.Sci Rep2017
27905419Drug response consistency in CCLE and CGP.Nature2016
26549455Engineered Mammalian RNAi Can Elicit Antiviral Protection that Negates the Requirement for the Interferon Response.Cell Rep2015
24736836Dimerization-based control of cooperativity.Mol Biosyst2014
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University of California San Francisco
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J. David Gladstone Institutes
Co-authored papers 15
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J. David Gladstone Institutes
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Icahn School of Medicine at Mount Sinai
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Melanie Ott
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Ann-Kathrin Reuschl
University College London
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Minkyu Kim
University of California san francisco
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Manisha Ummadi
University of California, San Francisco
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Michael J McGregor
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Release 1.2