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Author Details

Alessandro Datti
University of Perugia
1991
97
38
PMIDPaper TitleJournal TitlePublished Year
36764576Academic drug discovery in an age of research abundance, and the curious case of chemical screens toward drug repositioning.Drug Discov Today2023
37511307Biochemical and Anthropometric Parameters for the Early Recognition of the Intrauterine Growth Restriction and Preterm Neonates at Risk of Impaired Neurodevelopment.Int J Mol Sci2023
37202533Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer.Commun Biol2023
35023164Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.EMBO J2022
35597023Retraction notice to "Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells" [Int. J. Biochem. Cell Biol. 43 (2011) 775-783].Int J Biochem Cell Biol2022
35914530Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis.Mol Cell2022
35913442Lesion Volume in a Bi- or Multivariate Prediction Model for the Management of PI-RADS v2.1 Score 3 Category Lesions.Turk J Urol2022
33234594An endogenous PI3K interactome promoting astrocyte-mediated neuroprotection identifies a novel association with RNA-binding protein ZC3H14.J Biol Chem2021
32295120Sorafenib as an Inhibitor of RUVBL2.Biomolecules2020
31864959Spleen tyrosine kinase expression is correlated with human papillomavirus in head and neck cancer.Oral Oncol2020
32094923A drug discovery platform to identify compounds that inhibit EGFR triple mutants.Nat Chem Biol2020
32062352Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis.EBioMedicine2020
32970704Flavopiridol causes cell cycle inhibition and demonstrates anti-cancer activity in anaplastic thyroid cancer models.PLoS One2020
30548903Cell-based high-throughput screen for small molecule inhibitors of Bax translocation.J Cell Mol Med2019
31534157Selenium maintains cytosolic Ca<sup>2+ </sup>homeostasis and preserves germination rates of maize pollen under H<sub>2</sub>O<sub>2</sub>-induced oxidative stress.Sci Rep2019
29617654Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.Cell Rep2018
29990484COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs.Life Sci2018
29899842High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.Oncotarget2018
30419054Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models.PLoS One2018
29069723Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer.Oncotarget2017
28157508Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors.Mol Cell2017
26781438Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer.Breast Cancer Res2016
26624983Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism.Oncotarget2016
27612511Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.Biol Open2016
27587383Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells.Haematologica2016
27571409RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.J Clin Invest2016
27521426The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.J Cell Sci2016
26942566High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor.Oncotarget2016
27006494Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma.Clin Cancer Res2016
26952093PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.J Transl Med2016
26724904Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.Stem Cell Reports2016
25877919Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.Genes Dev2015
26077472Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death.Cancer Res2015
26115765Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy.Mol Oncol2015
26109054Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.Genes Dev2015
25832785Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.Apoptosis2015
25165489A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.Genome Med2014
25330770Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.EMBO Mol Med2014
23129004Luteolin inhibition of V-ATPase a3-d2 interaction decreases osteoclast resorptive activity.J Cell Biochem2013
24104479A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.Mol Syst Biol2013
24265703RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.PLoS One2013
23835716MicroRNA signature obtained from the comparison of aggressive with indolent non-Hodgkin lymphomas: potential prognostic value in mantle-cell lymphoma.J Clin Oncol2013
23974104High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors.Cell Cycle2013
23439581Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing-remitting multiple sclerosis patients.Mult Scler2013
23202731Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.J Clin Invest2013
23319603High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.Proc Natl Acad Sci U S A2013
23318959Inhibition of intracellular dipeptidyl peptidases 8 and 9 enhances parthenolide's anti-leukemic activity.Leukemia2013
22160482A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside.Blood2012
22829238Drug-mediated inhibition of Fli-1 for the treatment of leukemia.Blood Cancer J2012
22585861Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Cancer Discov2012
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Collaborators

Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 34
Aaron D Schimmer
Princess Margaret Cancer Centre
Co-authored papers 20
Rose Hurren
Princess Margaret Cancer Centre
Co-authored papers 15
Frederick S Vizeacoumar
College of Medicine, University of Saskatchewan
Co-authored papers 14
Marcela Gronda
Princess Margaret Cancer Centre
Co-authored papers 13
Jason Moffat
University of Toronto
Co-authored papers 9
James W Dennis
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University Avenue R988
Co-authored papers 9
Rima Al-Awar
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 7
Eldad Zacksenhaus
University of Toronto
Co-authored papers 7
Paul C Boutros
University of California los angeles
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John W Barrett
University of Western Ontario
Co-authored papers 5
Stephanie Danielle MacNeil
Schulich School of Medicine and Dentistry, Western University
Co-authored papers 5
Joe S Mymryk
University of Western Ontario
Co-authored papers 5
John Yoo
Schulich School of Medicine & Dentistry, Western University
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Nicole Pinto
School of Public Policy at the University of Calgary
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David Uehling
Ontario Institute for Cancer Research, University Avenue
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Anthony C Nichols
University of Western Ontario
Co-authored papers 5
Franco J Vizeacoumar
College of Medicine, University of Saskatchewan
Co-authored papers 5
Kevin Fung
Schulich School of Medicine & Dentistry, Western University, Victoria Hospital
Co-authored papers 5
Kara M Ruicci
Schulich School of Medicine and Dentistry, Western University
Co-authored papers 5
Charles Boone
University of Toronto
Co-authored papers 4
Ahmed Aman
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 4
Shereen Ezzat
University of Toronto
Co-authored papers 4
Methvin Isaac
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 4
Farhad Ghasemi
Western University
Co-authored papers 4
Benjamin J Blencowe
University of Toronto
Co-authored papers 4
Brenda J Andrews
University of Toronto
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Michael Prakesch
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Hong Han
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Release 1.2