Author details

Full Name

Kevin Fitzgerald

Affiliation

ORCID

Career Start Year

1989

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37230214	Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.	Metabolism	2023
37031257	RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.		2023
36586437	Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.	J Lipid Res	2023
36747758	Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.	bioRxiv	2023
34154993	The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of -Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human.	Drug Metabolism and Disposition	2022
35654979	Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.	Nature Biotechnology	2022
35896531	Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.	Nature Communications	2022
35736224	From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.	Nucleic Acids Research	2022
33180328	Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model.	American Journal of Hematology	2021
33087494	Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis.	Neurology	2021
32735622	Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1-/- mouse model.	PLoS ONE	2020
32347936	Generation and validation of structurally defined antibody-siRNA conjugates.	Nucleic Acids Research	2020
31990410	Mild iron deficiency does not ameliorate the phenotype of a murine erythropoietic protoporphyria model.	American Journal of Hematology	2020
31981640	Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.	Toxicology and Applied Pharmacology	2020
32539694	Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence.	BMC Cancer	2020
31193726	Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis.	Molecular Therapy - Methods and Clinical Development	2019
31802031	The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs.	Nature Nanotechnology	2019
30463937	An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema.	RNA	2019
29206679	Predicting Intestinal Adaptation in Pediatric Intestinal Failure: A Retrospective Cohort Study.	Annals of Surgery	2019
30820542	Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.	Nucleic Acids Research	2019
31463950	Early Predictors of Enteral Autonomy in Pediatric Intestinal Failure Resulting From Short Bowel Syndrome: Development of a Disease Severity Scoring Tool.	Journal of Parenteral and Enteral Nutrition	2019
30803790	The evolution of the serial transverse enteroplasty for pediatric short bowel syndrome at a single institution.	Journal of Pediatric Surgery	2019
30726693	Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria.	New England Journal of Medicine	2019
29493547	Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.	J Clin Invest	2018
29687920	Jewish, Christian and Muslim theological perspectives about xenotransplantation.	Xenotransplantation	2018
29498084	RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of Î²-thalassemia intermedia.	Am J Hematol	2018
27959715	A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.	N Engl J Med	2017
28467871	A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.	New England Journal of Medicine	2017
28768177	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.		2017
28981809	Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.	Nucleic Acids Research	2017
28972537	Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.	J Clin Invest	2017
28877461	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.		2017
27432743	An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.	J Am Soc Nephrol	2017
28189450	Persistence of hepatic fibrosis in pediatric intestinal failure patients treated with intravenous fish oil lipid emulsion.	Journal of Pediatric Surgery	2017
28190552	Use of balloon dilatation for management of postoperative intestinal strictures in children with short bowel syndrome.	Journal of Pediatric Surgery	2017
26655602	Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.		2016
26921935	Prevalence of renal abnormality in pediatric intestinal failure.	Journal of Pediatric Surgery	2016
27377419	Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development.		2016
27280687	RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.	Sci Transl Med	2016
27033334	Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.	Amyloid	2016
27474787	Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys.	Hepatology	2016
27444755	Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.	Circ Res	2016
24950695	Silencing of CCR2 in myocarditis.	European Heart Journal	2015
25800955	Macrophages retain hematopoietic stem cells in the spleen via VCAM-1.	Journal of Experimental Medicine	2015
25786782	Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivo.	ChemBioChem	2015
25557851	Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of Î²-thalassemia intermedia.	American Journal of Hematology	2015
25957903	Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.		2015
26001325	QT interval correction assessment in the anesthetized guinea pig.		2015
26220182	Identification of siRNA delivery enhancers by a chemical library screen.	Nucleic Acids Research	2015
26528940	Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification.	Molecular Therapy - Nucleic Acids	2015