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Author Details

Mark Connors
National Institute of Allergy and Infectious Diseases, National Institutes of Health
1990
139
67
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37349337Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections.Nat Commun2023
38096385HIV vaccines induce CD8<sup>+</sup> T cells with low antigen receptor sensitivity.Science2023
36582240Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings.Front Immunol2022
35401559High-Throughput B Cell Epitope Determination by Next-Generation Sequencing.Front Immunol2022
33471124Lost in Translation: Lack of CD4 Expression due to a Novel Genetic Defect.J Infect Dis2021
33785631Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.mBio2021
33709324Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?Curr HIV/AIDS Rep2021
33536176Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity <i>Ex Vivo and In Vivo</i>.J Virol2021
33529172A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity.J Clin Invest2021
34200826Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography.Antibodies (Basel)2021
33460347SARS-CoV-2 Vaccines: Much Accomplished, Much to Learn.Ann Intern Med2021
32130953VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.Cell Host Microbe2020
32907983Antigenic Restimulation of Virus-Specific Memory CD8<sup>+</sup> T Cells Requires Days of Lytic Protein Accumulation for Maximal Cytotoxic Capacity.J Virol2020
31004012Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine.Sci Immunol2019
31787378High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity.Cell2019
31830058Toll-like receptor 7-adapter complex modulates interferon-α production in HIV-stimulated plasmacytoid dendritic cells.PLoS One2019
31415245Adoptive lymphocyte transfer to an HIV-infected progressor from an elite controller.JCI Insight2019
29309060Functional interrogation and mining of natively paired human V<sub>H</sub>:V<sub>L</sub> antibody repertoires.Nat Biotechnol2018
29875402MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.Mucosal Immunol2018
30270043RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.Cell2018
30552024Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.Immunity2018
30538178Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation.mBio2018
29444432Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.Cell Rep2018
29461980Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.J Clin Invest2018
29505593Potential of conventional &amp; bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C &amp; D infections.PLoS Pathog2018
28076415Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.PLoS Pathog2017
28514685Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.Immunity2017
28539448Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys.J Virol2017
28931639Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.Science2017
28052137Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting.PLoS Pathog2017
27053554Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.J Virol2016
28783677Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.Sci Immunol2016
26663780IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control.J Immunol2016
27851912Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.Immunity2016
27760334Class II-Restricted CD8s: New Lessons Violate Old Paradigms.Immunity2016
27630237Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size.J Virol2016
27654288Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding.J Virol2016
27453467Multiple Origins of Virus Persistence during Natural Control of HIV Infection.Cell2016
27174988Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.Science2016
27299673Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.PLoS One2016
27114034Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.Cell2016
27191167Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.PLoS Comput Biol2016
25807248Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.PLoS Pathog2015
26546609Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.J Immunol2015
26537682A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy.J Virol2015
26678998Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression.PLoS One2015
25865483Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.Cell2015
25900654Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.mBio2015
25988888Success and failure of the cellular immune response against HIV-1.Nat Immunol2015
26004070Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.Cell2015
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Collaborators

Stephen A Migueles
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 63
John R Mascola
Co-authored papers 42
Peter D Kwong
Co-authored papers 29
Nicole A Doria-Rose
Co-authored papers 28
Mark K Louder
Co-authored papers 21
Sijy O'Dell
Co-authored papers 21
Ivelin S Georgiev
Co-authored papers 19
Krisha McKee
Co-authored papers 19
Baoshan Zhang
Co-authored papers 16
Tongqing Zhou
Co-authored papers 15
Barton F Haynes
Co-authored papers 14
Stephen D Schmidt
Co-authored papers 14
Gwo-Yu Chuang
Co-authored papers 13
Lawrence Shapiro
Zuckerman Mind Brain Behaviour Institute
Co-authored papers 12
Michael G Joyce
Co-authored papers 12
Yongping Yang
Co-authored papers 12
Aliaksandr Druz
Co-authored papers 10
Richard T Davey
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 9
Young Do Kwon
Co-authored papers 9
Marie Pancera
Co-authored papers 8
Cinque Soto
Co-authored papers 8
Henry Clifford Lane
Division of Clinical Research, National Institutes of Allergy and Infectious Diseases
Co-authored papers 7
Michael S Seaman
Co-authored papers 6
James C Mullikin
National Human Genome Research Institute, National Institutes of Health
Co-authored papers 6
Jason M Brenchley
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 5
John-Paul Todd
Co-authored papers 5
Steven G Deeks
University of California san francisco
Co-authored papers 5
Bette Korber
Co-authored papers 4
Jeffrey D Lifson
Frederick National Laboratory
Co-authored papers 4
George M Shaw
Co-authored papers 4
Release 1.2