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Author Details

Aashish Manglik
Department of Pharmaceutical Chemistry, University of California San Francisco
2008
62
40
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36922591Structural basis of odorant recognition by a human odorant receptor.Nature2023
38014344Engineered odorant receptors illuminate structural principles of odor discrimination.bioRxiv2023
37828150Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets.Commun Biol2023
37292845GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.bioRxiv2023
34711980Selective G protein signaling driven by substance P-neurokinin receptor dynamics.Nat Chem Biol2022
36250629Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling.Elife2022
35940205Autoantibody mimicry of hormone action at the thyrotropin receptor.Nature2022
35902590Fusion protein strategies for cryo-EM study of G protein-coupled receptors.Nat Commun2022
34562250Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody.Methods Mol Biol2022
33974910Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.Cell2021
33893299Protein design and variant prediction using autoregressive generative models.Nat Commun2021
33727310Surface Proteomics Reveals CD72 as a Target for <i>In Vitro</i>-Evolved Nanobody-Based CAR-T Cells in <i>KMT2A/MLL1</i>-Rearranged B-ALL.Cancer Discov2021
34013269CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.bioRxiv2021
34031651CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.Res Sq2021
32511497Test performance evaluation of SARS-CoV-2 serological assays.medRxiv2020
34109255Universal Polymerase Chain Reaction and Antibody Testing Demonstrate Little to No Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in a Rural Community.Open Forum Infect Dis2020
32096468Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells.Elife2020
31653480Molecular Basis of Opioid Action: From Structures to New Leads.Biol Psychiatry2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
33139559Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.Proc Natl Acad Sci U S A2020
33154106An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.Science2020
32855547Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.Nat Biotechnol2020
32817938An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.bioRxiv2020
32699850Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.bioRxiv2020
32814342Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.Nature2020
32724208Author Correction: Structural insights into μ-opioid receptor activation.Nature2020
32412788β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19.Circulation2020
31263273Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.Nature2019
29434346Yeast surface display platform for rapid discovery of conformationally selective nanobodies.Nat Struct Mol Biol2018
30213947Development of an antibody fragment that stabilizes GPCR/G-protein complexes.Nat Commun2018
29932421Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor.Elife2018
29899455Structure of the µ-opioid receptor-G<sub>i</sub> protein complex.Nature2018
29754753A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.Neuron2018
29581292Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.Proc Natl Acad Sci U S A2018
27959623Nanobodies to Study G Protein-Coupled Receptor Structure and Function.Annu Rev Pharmacol Toxicol2017
28967738Structural Basis for G Protein-Coupled Receptor Activation.Biochemistry2017
26894529High-density grids for efficient data collection from multiple crystals.Acta Crystallogr D Struct Biol2016
27362234Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.Nature2016
27533032Structure-based discovery of opioid analgesics with reduced side effects.Nature2016
27409812Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.Nature2016
27042935Crystal structure of the human Ï¿1 receptor.Nature2016
25770216G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).J Biol Chem2015
26245379Structural insights into µ-opioid receptor activation.Nature2015
26245377Propagation of conformational changes during μ-opioid receptor activation.Nature2015
26604307Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.Proc Natl Acad Sci U S A2015
26089515SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.Science2015
25981665Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.Cell2015
25813845A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins.J Biomol NMR2015
24534489The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin.Curr Opin Cell Biol2014
25362050Goniometer-based femtosecond crystallography with X-ray free electron lasers.Proc Natl Acad Sci U S A2014
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Collaborators

Andrew C Kruse
Blavatnik Institute, Harvard Medical School
Co-authored papers 17
Yifan Cheng
Quantitative Bioscience Institute, University of California san francisco
Co-authored papers 10
Christian B Billesb??lle
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 9
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 7
Kaihua Zhang
Henan Normal University
Co-authored papers 7
Ishan Deshpande
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 6
Caleigh M Azumaya
Fred Hutchinson Cancer Center
Co-authored papers 6
Gregory E Merz
University of California san francisco
Co-authored papers 5
Kaitlin Schaefer
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 5
Alexandrea N Rizo
University of California san francisco
Co-authored papers 5
Danielle L Swaney
J. David Gladstone Institutes
Co-authored papers 5
David Bulkley
University of California, San Francisco (UCSF) School of Medicine
Co-authored papers 5
Sergei Pourmal
University of California san francisco
Co-authored papers 5
Daniel Asarnow
University of California San Francisco
Co-authored papers 5
Un Seng Chio
University of California san francisco
Co-authored papers 5
Raphael Trenker
Cardiovascular Research Institute, University of California San Francisco
Co-authored papers 5
Huong T Kratochvil
Department of Pharmaceutical Chemistry, University of California-San Francisco
Co-authored papers 5
Meghna Gupta
University of California san francisco
Co-authored papers 5
Amber M Smith
University of California san francisco
Co-authored papers 5
Axel F Brilot
University of California san francisco
Co-authored papers 5
Cristina Puchades
University of California San Francisco (UCSF) School of Medicine
Co-authored papers 5
Henry C Nguyen
Shanghai Clinical Research and Trial Center
Co-authored papers 5
Aaron M Ring
Yale University School of Medicine
Co-authored papers 4
Yanxin Liu
University of California san francisco
Co-authored papers 4
James S Fraser
University of California san francisco
Co-authored papers 4
Robert J Lefkowitz
Co-authored papers 4
Carl-Mikael Suomivuori
Stanford University School of Medicine
Co-authored papers 3
Nadia Herrera
University of California san francisco
Co-authored papers 3
Eric Tse
School of Clinical Medicine, University of Hong Kong
Co-authored papers 3
Lily Y-L Lee
Department of Pharmaceutical Chemistry, University of California san francisco
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