Author details

Full Name

Michael Costanzo

Affiliation

ORCID

Career Start Year

1999

Papers

104

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37436802	Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability.	Mol Biol Cell	2023
37891180	N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.	Nat Commun	2023
37205480	K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ).	bioRxiv	2023
37201508	Reproducibility metrics for context-specific CRISPR screens.	Cell Syst	2023
36037231	Repression of essential cell cycle genes increases cellular fitness.	PLoS Genet	2022
34739032	Tubulin isotypes optimize distinct spindle positioning mechanisms during yeast mitosis.	J Cell Biol	2021
34018332	A method for benchmarking genetic screens reveals a predominant mitochondrial bias.	Mol Syst Biol	2021
33751052	Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomal instability in Saccharomyces cerevisiae.	Genetics	2021
33958448	Environmental robustness of the global yeast genetic interaction network.	Science	2021
33462440	Ï¿-SGA: synthetic genetic array analysis for systematically screening and quantifying trigenic interactions in yeast.	Nat Protoc	2021
33974913	Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase.	Mol Cell	2021
32694731	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	Nat Metab	2020
32295767	Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in <i>Saccharomyces cerevisiae</i>.	G3 (Bethesda)	2020
32032354	Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.	PLoS Genet	2020
32586993	Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.	Science	2020
30901552	Global Genetic Networks and the Genotype-to-Phenotype Relationship.	Cell	2019
30763569	Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.	J Mol Biol	2019
31537791	Discovering genetic interactions bridging pathways in genome-wide association studies.	Nat Commun	2019
31172013	Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase.	Microb Cell	2019
29702647	Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs.	PLoS Genet	2018
30059827	Integrating genetic and protein-protein interaction networks maps a functional wiring diagram of a cell.	Curr Opin Microbiol	2018
30012561	A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A.	Genetics	2018
29875260	The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.	J Cell Biol	2018
30376562	Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.	PLoS Comput Biol	2018
30130531	Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis.	Dev Cell	2018
29674565	Systematic analysis of complex genetic interactions.	Science	2018
29526462	Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.	Cell	2018
28131822	Genome-Scale Networks Link Neurodegenerative Disease Genes to Î±-Synuclein through Specific Molecular Pathways.	Cell Syst	2017
28957314	Pathway-based discovery of genetic interactions in breast cancer.	PLoS Genet	2017
28903051	Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.	Cell Rep	2017
28542158	Identifying pathogenicity of human variants via paralog-based yeast complementation.	PLoS Genet	2017
28759014	Functional annotation of chemical libraries across diverse biological processes.	Nat Chem Biol	2017
28325812	TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network.	G3 (Bethesda)	2017
29161247	Errata: Functional annotation of chemical libraries across diverse biological processes.	Nat Chem Biol	2017
29161244	Errata: Functional annotation of chemical libraries across diverse biological processes.	Nat Chem Biol	2017
27820830	Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication.	PLoS Genet	2016
26975778	An extended set of yeast-based functional assays accurately identifies human disease mutations.	Genome Res	2016
26837754	Chromosome-Specific and Global Effects of Aneuploidy in Saccharomyces cerevisiae.	Genetics	2016
26871637	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	Cell	2016
27037078	Synthetic Genetic Arrays: Automation of Yeast Genetics.	Cold Spring Harb Protoc	2016
27037072	Synthetic Genetic Array Analysis.	Cold Spring Harb Protoc	2016
26582391	TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.	Mol Biol Cell	2016
27811238	Exploring genetic suppression interactions on a global scale.	Science	2016
27708008	A global genetic interaction network maps a wiring diagram of cellular function.	Science	2016
27617677	Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci.	Cell Syst	2016
26545110	Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.	PLoS Genet	2015
26878058	Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.	ACS Infect Dis	2015
24835459	Genome-wide analysis reveals novel and discrete functions for tubulin carboxy-terminal tails.	Curr Biol	2014
25213244	Synthetic genetic array analysis for global mapping of genetic networks in yeast.	Methods Mol Biol	2014
23651995	Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops.	Nat Commun	2013