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Author Details

Klaus H Kaestner
Department of Genetics and Institute for Diabetes, University of Pennsylvania
1986
400
102
PMIDPaper TitleJournal TitlePublished Year
37966551Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.Diabetologia2024
36503150H3K27me3 Demethylases Maintain the Transcriptional and Epigenomic Landscape of the Intestinal Epithelium.Cell Mol Gastroenterol Hepatol2023
37507088Mammalian Intestinal Development and Differentiation-The State of the Art.Cell Mol Gastroenterol Hepatol2023
37875977Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data.Genome Biol2023
37872177Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1.Nat Commun2023
37813160In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.Dev Biol2023
37188822Single-cell expression profiling of islets generated by the Human Pancreas Analysis Program.Nat Metab2023
37037491Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy.Cancer Commun (Lond)2023
36778447Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data.bioRxiv2023
36712052AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics.bioRxiv2023
36711819Computational workflow and interactive analysis of single-cell expression profiling of islets generated by the Human Pancreas Analysis Program.bioRxiv2023
36766701The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration.Cells2023
35108513Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.Cell Metab2022
35652923Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.Diabetologia2022
35477756β-Hydroxybutyrate suppresses colorectal cancer.Nature2022
35835117FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma.Dev Cell2022
35642629α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals.J Clin Invest2022
35537191Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits.Sleep2022
35941159Adaptation to chronic ER stress enforces pancreatic β-cell plasticity.Nat Commun2022
360706833D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk.Cell Metab2022
36206763Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program.Cell Metab2022
36100080Genetic activation of glucokinase in a minority of pancreatic beta cells causes hypoglycemia in mice.Life Sci2022
35988690Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling.J Hepatol2022
36117551In Vivo Screen Identifies Liver X Receptor Alpha Agonism Potentiates Sorafenib Killing of Hepatocellular Carcinoma.Gastro Hep Adv2022
34942163Offspring from trained male mice inherit improved muscle mitochondrial function through PPAR co-repressor modulation.Life Sci2022
35297680Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus.Hum Gene Ther2022
33432171Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations.Nat Med2021
33545036TCR<sup>+</sup>/BCR<sup>+</sup> dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes.Cell2021
33621209Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver.JCI Insight2021
33558985Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.Diabetologia2021
33636105FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity.Dev Cell2021
33610858Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states.Mol Metab2021
33859189Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.Nat Commun2021
35008427Paternal Exercise Improves the Metabolic Health of Offspring via Epigenetic Modulation of the Germline.Int J Mol Sci2021
34850398Cancer stem cells: advances in biology and clinical translation-a Keystone Symposia report.Ann N Y Acad Sci2021
34529988Highly Multiplexed Image Analysis of Intestinal Tissue Sections in Patients With Inflammatory Bowel Disease.Gastroenterology2021
34752420Gq signaling in α cells is critical for maintaining euglycemia.JCI Insight2021
34416394What is a β cell? - Chapter I in the Human Islet Research Network (HIRN) review series.Mol Metab2021
34772482CMGH: The year in review.Cell Mol Gastroenterol Hepatol2021
33993983FoxL1<sup>+</sup> mesenchymal cells are a critical source of Wnt5a for midgut elongation during mouse embryonic intestinal development.Cells Dev2021
33964205Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.Dev Cell2021
34029742A FoxL1-CreERT-2A-tdTomato Mouse Labels Subepithelial Telocytes.Cell Mol Gastroenterol Hepatol2021
33436641Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy.Nat Commun2021
31629814The Dynamic Chromatin Architecture of the Regenerating Liver.Cell Mol Gastroenterol Hepatol2020
31759059A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice.Gastroenterology2020
31866400Tracking Dysbiosis Where It Matters.Cell Mol Gastroenterol Hepatol2020
31636388Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer.Oncogene2020
32049053Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression.Immunity2020
33106804SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells.bioRxiv2020
33207245SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells.Cell Metab2020
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Collaborators

Jonathan Schug
University of Pennsylvania Perelman School of Medicine
Co-authored papers 54
Peter White
The Ohio State University
Co-authored papers 25
John Brestelli
University of Pennsylvania
Co-authored papers 16
Benjamin Glaser
Co-authored papers 12
Catherine S Lee
Children's Hospital of Philadelphia
Co-authored papers 11
Elisabetta Manduchi
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Co-authored papers 9
Christian J Stoeckert
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 9
Vincent W Yang
Co-authored papers 8
Vasumathi Kameswaran
Gladstone Institutes
Co-authored papers 8
Yuval Dor
Hadassah-Hebrew University Medical Center
Co-authored papers 8
Golnaz Vahedi
Co-authored papers 8
Maike Sander
Co-authored papers 7
A P Monaghan
University of Missouri Kansas City School of Medicine
Co-authored papers 7
Kyoung-Jae Won
Co-authored papers 6
Struan F A Grant
Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia
Co-authored papers 5
Deborah F Pinney
University of Pennsylvania
Co-authored papers 4
Jason K Kim
Co-authored papers 4
Athanasios Arsenlis
Lawrence Livermore National Laboratory
Co-authored papers 4
L M Scearce
University of Pennsylvania
Co-authored papers 4
Andrew D Wells
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Co-authored papers 4
Joan Mazzarelli
Center for Bioinformatics, University of Pennsylvania
Co-authored papers 4
Rexford S Ahima
Johns Hopkins University
Co-authored papers 4
Mingyao Li
Co-authored papers 4
Matthew E Johnson
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Co-authored papers 3
Peter Lichter
German Cancer Research Center (DKFZ)
Co-authored papers 3
Amr M Ghaleb
Co-authored papers 3
Shalev Itzkovitz
Co-authored papers 3
Shelley L Berger
Penn Epigenetics Institute, Perelman School of Medicine
Co-authored papers 3
Mukesh K Jain
Co-authored papers 3
Kyong-Mi Chang
Corporal Michael J Crescenz VA Medical Center
Co-authored papers 3
Release 1.2