Author details

Full Name

Brian M Baker

Affiliation

ORCID

Career Start Year

1996

Papers

117

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37227784	Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality.		2023
38085776	Structural and physical features that distinguish tumor-controlling from inactive cancer neoepitopes.		2023
37891435	T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome.	Nat Rev Drug Discov	2023
37966257	CD8+ T Cell-Dependent Antitumor Activity InÂ Vivo of a Mass Spectrometry-Identified Neoepitope despite Undetectable CD8+ Immunogenicity InÂ Vitro.		2023
37459192	The Energetic Landscape of Catch Bonds in TCR Interfaces.		2023
36798151	Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality.		2023
34995990	A previously unappreciated polymorphism in the beta chain of I-A expressed in autoimmunity-prone SJL mice: Combined impact on antibody, CD4 T cell recognition and MHC class II dimer structural stability.	Molecular Immunology	2022
35840635	Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma.	Scientific Reports	2022
35484264	Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.	Nat Med	2022
35550277	Peptide-dependent tuning of major histocompatibility complex motional properties and the consequences for cellular immunity.		2022
35547730	Physicochemical Heuristics for Identifying High Fidelity, Near-Native Structural Models of Peptide/MHC Complexes.	Frontiers in Immunology	2022
35725942	Chaperoning the dance of antigen presentation.	Nature Chemical Biology	2022
36424374	A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry.	Nature Communications	2022
35344834	Engineering the T cell receptor for fun and profit: Uncovering complex biology, interrogating the immune system, and targeting disease.	Current Opinion in Structural Biology	2022
34721421	Advanced Genomics-Based Approaches for Defining Allograft Rejection With Single Cell Resolution.	Frontiers in Immunology	2021
31552791	LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner its armadillo domain.	Small GTPases	2021
33468649	Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner.	Proceedings of the National Academy of Sciences of the United States of America	2021
33891944	Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.	Journal of Biological Chemistry	2021
33665637	Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting.	Cell Rep Med	2021
33990005	Tumor rejection properties of gp100-specific T cells correlate with T cell receptor binding affinity towards the wild type rather than anchor-modified antigen.	Molecular Immunology	2021
34260940	HLA class-I-peptide stability mediates CD8<sup>+</sup> TÂ cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV.	Cell Rep	2021
33355667	High-throughput modeling and scoring of TCR-pMHC complexes to predict cross-reactive peptides.	Bioinformatics	2021
33320837	An unbiased approach to defining bona fide cancer neoepitopes that elicit immune-mediated cancer rejection.	J Clin Invest	2021
34741035	Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope.	Nature Communications	2021
33074657	An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes.	Biochemistry	2020
31589793	Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen.	Proteins	2020
32162475	Synthesis and Biological Evaluation of Hapten-Clicked Analogues of The Antigenic Peptide Melan-A/MART-1.	ChemMedChem	2020
32807968	Structural dissimilarity from self drives neoepitope escape from immune tolerance.	Nature Chemical Biology	2020
31156737	Low-Dimensional Metal-Organic Coordination Structures on Graphene.	Journal of Physical Chemistry C	2019
31595324	Understanding TCR affinity, antigen specificity, and cross-reactivity to improve TCR gene-modified T cells for cancer immunotherapy.	Cancer Immunology, Immunotherapy	2019
31555277	Structure Based Prediction of Neoantigen Immunogenicity.	Frontiers in Immunology	2019
30009548	Molecular properties of gp100-reactive T-cell receptors drive the cytokine profile and antitumor efficacy of transgenic host T cells.	Pigment Cell Melanoma Res	2019
30617019	Improving T Cell Receptor On-Target Specificity via Structure-Guided Design.	Molecular Therapy	2019
31130956	Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility.	Frontiers in Immunology	2019
31219806	Mass spectrometry driven exploration reveals nuances of neoepitope-driven tumor rejection.	JCI insight	2019
29503203	Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells.	Mol Ther	2018
29052782	Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.	Cancer Immunol Immunother	2018
30449534	The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics.	Seminars in Cell and Developmental Biology	2018
30224695	T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability.	Nature Chemical Biology	2018
29264697	Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.	Cancer Immunol Immunother	2018
28160322	ATLAS: A database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes.	Proteins	2017
28824655	Peptide and Peptide-Dependent Motions in MHC Proteins: Immunological Implications and Biophysical Underpinnings.	Frontiers in Immunology	2017
28634816	Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.	Cancer Immunol Immunother	2017
28572406	How an alloreactive T-cell receptor achieves peptide and MHC specificity.	Proceedings of the National Academy of Sciences of the United States of America	2017
28923982	Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.	J Immunol	2017
28696685	Modeling Sequence-Dependent Peptide Fluctuations in Immunologic Recognition.	Journal of Chemical Information and Modeling	2017
27939452	MHC Bias by T Cell Receptors: Genetic Evidence for MHC and TCR Coevolution.	Trends in Immunology	2017
28197404	Using Global Analysis to Extend the Accuracy and Precision of Binding Measurements with T cell Receptors and Their Peptide/MHC Ligands.	Frontiers in Molecular Biosciences	2017
27624308	A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.	Protein Eng Des Sel	2016
26884163	How structural adaptability exists alongside HLA-A2 bias in the human Î±Î² TCR repertoire.	Proc Natl Acad Sci U S A	2016