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Author Details

Subramanyam Swaminathan
Brookhaven National Laboratory
1982
123
38
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
26818694β-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies.Biochemistry2016
27353886Small molecule non-peptide inhibitors of botulinum neurotoxin serotype E: Structure-activity relationship and a pharmacophore model.Bioorg Med Chem2016
27543389Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity.Bioorg Med Chem2016
25751268Recent developments with metalloprotease inhibitor class of drug candidates for botulinum neurotoxins.Curr Top Med Chem2015
26275678Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.Bioorg Med Chem2015
26639353Molecular Assembly of Clostridium botulinum progenitor M complex of type E.Sci Rep2015
26522088Interactions of a potent cyclic peptide inhibitor with the light chain of botulinum neurotoxin A: Insights from X-ray crystallography.Bioorg Med Chem2015
24955762Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate.Biochemistry2014
24832101Structural characterization and function determination of a nonspecific carboxylate esterase from the amidohydrolase superfamily with a promiscuous ability to hydrolyze methylphosphonate esters.Biochemistry2014
24831290Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1.Biochemistry2014
24872444Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.Proc Natl Acad Sci U S A2014
23295479Structure of alanine racemase from Oenococcus oeni with bound pyridoxal 5'-phosphate.Acta Crystallogr Sect F Struct Biol Cryst Commun2013
24060347Divergent evolution of ligand binding in the o-succinylbenzoate synthase family.Biochemistry2013
23972005Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes.Biochemistry2013
23779108The C terminus of the catalytic domain of type A botulinum neurotoxin may facilitate product release from the active site.J Biol Chem2013
23239355Structure-based drug discovery for botulinum neurotoxins.Curr Top Microbiol Immunol2013
23214420Functional annotation and three-dimensional structure of an incorrectly annotated dihydroorotase from cog3964 in the amidohydrolase superfamily.Biochemistry2013
22109989Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis.Chembiochem2012
23192024Structure of a periplasmic glucose-binding protein from Thermotoga maritima.Acta Crystallogr Sect F Struct Biol Cryst Commun2012
23097747Inhibition of catalytic activities of botulinum neurotoxin light chains of serotypes A, B and E by acetate, sulfate and calcium.Int J Biochem Mol Biol2012
22525749Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling.Acta Crystallogr D Biol Crystallogr2012
22274537Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening.Chem Commun (Camb)2012
22072612Structural insight into mechanism and diverse substrate selection strategy of L-ribulokinase.Proteins2012
20961849Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity.J Biol Chem2011
21998098The catalase activity of diiron adenine deaminase.Protein Sci2011
21914803Structural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum.J Biol Chem2011
21592305Molecular structures and functional relationships in clostridial neurotoxins.FEBS J2011
21710971Pa0148 from Pseudomonas aeruginosa catalyzes the deamination of adenine.Biochemistry2011
21387413Structural basis for a ribofuranosyl binding protein: insights into the furanose specific transport.Proteins2011
21185305Structural and functional studies of fatty acyl adenylate ligases from E. coli and L. pneumophila.J Mol Biol2011
21247091Catalytic mechanism and three-dimensional structure of adenine deaminase.Biochemistry2011
19787770Structural studies on cytosolic domain of magnesium transporter MgtE from Enterococcus faecalis.Proteins2010
20711775Low pH-induced pore formation by the T domain of botulinum toxin type A is dependent upon NaCl concentration.J Membr Biol2010
20737437Structure of a putative BenF-like porin from Pseudomonas fluorescens Pf-5 at 2.6 A resolution.Proteins2010
20415463Discovery and structure determination of the orphan enzyme isoxanthopterin deaminase .Biochemistry2010
20057058Structure of YqgQ protein from Bacillus subtilis, a conserved hypothetical protein.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
19219566Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies.J Struct Funct Genomics2009
19358546Functional annotation of two new carboxypeptidases from the amidohydrolase superfamily of enzymes.Biochemistry2009
19543288Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F.Nat Struct Mol Biol2009
19118561Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation.J Mol Biol2009
18175317X-ray crystal structure of the B component of Hemolysin BL from Bacillus cereus.Proteins2008
19079550UPF201 archaeal specific family members reveal structural similarity to RNA-binding proteins but low likelihood for RNA-binding function.PLoS One2008
18818739Substrate binding mode and its implication on drug design for botulinum neurotoxin A.PLoS Pathog2008
18498110Crystal structure of a putative lysostaphin peptidase from Vibrio cholerae.Proteins2008
18482846High level expression of the light chain of botulinum neurotoxin serotype C1 and an efficient HPLC assay to monitor its proteolytic activity.Protein Expr Purif2008
18658150SNAP-25 substrate peptide (residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E.J Biol Chem2008
18707125Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase.Biochemistry2008
18323598A novel acetate-bound complex of human carbonic anhydrase II.Acta Crystallogr Sect F Struct Biol Cryst Commun2008
18247349A novel mode of dimerization via formation of a glutamate anhydride crosslink in a protein crystal structure.Proteins2008
18245086Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complex.J Biol Chem2008
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Collaborators

The State University of New Jersey
Co-authored papers 39
Brookhaven National Laboratory
Co-authored papers 35
Brookhaven National Laboratory
Co-authored papers 25
National Forensic Sciences University
Co-authored papers 17
Eli Lilly and Co.
Co-authored papers 15
Albert Einstein College of Medicine
Co-authored papers 15
Texas A&M University, College Station
Co-authored papers 11
Albert Einstein College of Medicine
Co-authored papers 11
University of California San Francisco
Co-authored papers 8
Brookhaven National Laboratory
Co-authored papers 7
Case Western Reserve University
Co-authored papers 6
Defence Institute of Physiology and Allied Sciences (DIPAS)
Co-authored papers 5
Co-authored papers 5
Albert Einstein College of Medicine
Co-authored papers 4
NYU Langone Hospital - Brooklyn Brooklyn
Co-authored papers 4
Harvard University
Co-authored papers 4
Indian Institute of Science Education and Research Pune
Co-authored papers 3
Argonne National Laboratory
Co-authored papers 3
New York University Grossman School of Medicine
Co-authored papers 3
New York SGX Research Center for Structural Genomics
Co-authored papers 3
Brookhaven National Laboratory
Co-authored papers 3
Cue BioPharma Inc.
Co-authored papers 3
Manipal University Jaipur
Co-authored papers 3
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Texas A&M University, College Station
Co-authored papers 3
Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Texas A&M University , College Station
Co-authored papers 2
Weizmann Institute of Science
Co-authored papers 2
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 2
Armed Forces Radiobiology Research Institute
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