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Author Details

Ineke Braakman
Utrecht University
1987
96
44
PMIDPaper TitleJournal TitlePublished Year
36216744Structure basis of CFTR folding, function and pharmacology.J Cyst Fibros2023
37530578Neil J. Bulleid (1960-2023), a virtuoso of protein folding and redox biology.EMBO J2023
37958724Transmembrane Helices 7 and 8 Confer Aggregation Sensitivity to the Cystic Fibrosis Transmembrane Conductance Regulator.Int J Mol Sci2023
36314692Hold the fold: how delayed folding aids protein secretion.EMBO J2022
36499495Redefining Hypo- and Hyper-Responding Phenotypes of CFTR Mutants for Understanding and Therapy.Int J Mol Sci2022
33296276Clinical and molecular characterization of the R751L-CFTR mutation.Am J Physiol Lung Cell Mol Physiol2021
33771570Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain.J Mol Biol2021
33781744The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue.J Biol Chem2021
32342578The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19.Environ Microbiol2020
30659068Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants.Life Sci Alliance2019
31657788Slowing ribosome velocity restores folding and function of mutant CFTR.J Clin Invest2019
30829321Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase.J Vis Exp2019
29229473Cystic fibrosis research topics featured at the 14th ECFS Basic Science Conference: Chairman's summary.J Cyst Fibros2018
28753126Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide.Elife2017
29055231Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis.Curr Opin Pharmacol2017
29091273Analysis of Disulfide Bond Formation.Curr Protoc Protein Sci2017
28510592Alteration of protein function by a silent polymorphism linked to tRNA abundance.PLoS Biol2017
26947578Co- and Post-Translational Protein Folding in the ER.Traffic2016
27713507Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G.Sci Rep2016
27744338Protein quality control at the endoplasmic reticulum.Essays Biochem2016
26769631Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus.J Gen Virol2016
25828453Folding of influenza virus hemagglutinin in insect cells is fast and efficient.J Biotechnol2015
26054799TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules.J Cell Sci2015
24967714Deletion of the highly conserved N-glycan at Asn260 of HIV-1 gp120 affects folding and lysosomal degradation of gp120, and results in loss of viral infectivity.PLoS One2014
23530257Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum.Philos Trans R Soc Lond B Biol Sci2013
24223594Quantifying Changes in the Cellular Thiol-Disulfide Status during Differentiation of B Cells into Antibody-Secreting Plasma Cells.Int J Cell Biol2013
24247433Two phases of disulfide bond formation have differing requirements for oxygen.J Cell Biol2013
23637286Protein folding in the endoplasmic reticulum.Cold Spring Harb Perspect Biol2013
23704559Cell biology. A sweet send-off.Science2013
23769672ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor.Mol Cell2013
23414306Peroxisome formation and maintenance are dependent on the endoplasmic reticulum.Annu Rev Biochem2013
22500805Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomes.Cell2012
21495850Protein folding and modification in the mammalian endoplasmic reticulum.Annu Rev Biochem2011
21547742CFTR Folding Consortium: methods available for studies of CFTR folding and correction.Methods Mol Biol2011
20089850Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum.J Biol Chem2010
21152102The primary folding defect and rescue of οF508 CFTR emerge during translation of the mutant domain.PLoS One2010
20144991Regulated increase in folding capacity prevents unfolded protein stress in the ER.J Cell Sci2010
20427571Peroxisomal membrane proteins insert into the endoplasmic reticulum.Mol Biol Cell2010
18922866Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution.J Virol2009
19630152Entering a new era with Ero.Nat Rev Mol Cell Biol2009
19805154Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1.Proc Natl Acad Sci U S A2009
18237398The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion.Retrovirology2008
18753405Evolution rescues folding of human immunodeficiency virus-1 envelope glycoprotein GP120 lacking a conserved disulfide bond.Mol Biol Cell2008
18653871Biochemistry. Cargo load reduction.Science2008
18653472Only five of 10 strictly conserved disulfide bonds are essential for folding and eight for function of the HIV-1 envelope glycoprotein.Mol Biol Cell2008
18619829Peroxisomes: minted by the ER.Curr Opin Cell Biol2008
18680510Protein folding includes oligomerization - examples from the endoplasmic reticulum and cytosol.FEBS J2008
16525120The return of the peroxisome.J Cell Sci2006
17030445Formation of peroxisomes: present and past.Biochim Biophys Acta2006
16464948A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients.J Clin Endocrinol Metab2006
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Collaborators

Albert J R Heck
Utrecht University
Co-authored papers 4
Sandrine Duvet
University Lille, CNRS
Co-authored papers 1
Marian J A Groot Koerkamp
Princess Maxima Center for Pediatric Oncology Research
Co-authored papers 1
Antoine Danchin
University of Hong Kong
Co-authored papers 1
Ryan A Rumantir
Co-authored papers 1
Jeroen J J P van den Beucken
Radboud University Medical Center
Co-authored papers 1
Krystn R Wagner
Johns Hopkins University School of Medicine
Co-authored papers 1
Thomas Pertel
Co-authored papers 1
Jeremy Luban
Co-authored papers 1
Thorsten Marquardt
University Children's Hospital Munster
Co-authored papers 1
Kenneth C Chu
Ontario Institute for Cancer Research
Co-authored papers 1
Nicholas J Harding
Big Data Institute, University of Oxford
Co-authored papers 1
Paul C Boutros
University of California los angeles
Co-authored papers 1
Andr?? G Uitterlinden
Erasmus University Medical Center
Co-authored papers 1
Alexandre M J J Bonvin
Bijvoet Center for Biomolecular Research, Utrecht University
Co-authored papers 1
Martijn A Huynen
Radboud University Medical Centre Nijmegen
Co-authored papers 1
Bradly G Wouters
Princess Margaret Cancer Centre, University Health Network and, University of Toronto
Co-authored papers 1
Gunnar von Heijne
Stockholm University
Co-authored papers 1
Marianne Koritzinsky
Princess Margaret Cancer Centre University Health Network
Co-authored papers 1
Huibert A P Pols
Co-authored papers 1
Fiana Levitin
Princess Margaret Cancer Center, University Health Network
Co-authored papers 1
Release 1.2