Author details

Full Name

Tarek M El-Achkar

Affiliation

ORCID

Career Start Year

2005

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37839688	Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project.	Am J Kidney Dis	2024
36454700	Defining protein expression in the kidney at large scale: from antibody validation to cytometry analysis.		2023
37986991	Single Nucleus RNA Sequencing of Remnant Kidney Biopsies and Urine Cell RNA Sequencing Reveal Cell Specific Markers of Covid-19 Acute Kidney Injury.	bioRxiv	2023
36913267	Computational Pathology Fusing Spatial Technologies.		2023
37468493	A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease.		2023
37340540	Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene.		2023
37333123	The chromatin landscape of healthy and injured cell types in the human kidney.	bioRxiv	2023
37256909	Water Loading and Uromodulin Secretion in Healthy Individuals and Idiopathic Calcium Stone Formers.		2023
36867975	Integrated Cytometry With Machine Learning Applied to High-Content Imaging of Human Kidney Tissue for In Situ Cell Classification and Neighborhood Analysis.		2023
35100812	The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain.		2022
35759740	The kidney protects against sepsis by producing systemic uromodulin.		2022
35675394	A reference tissue atlas for the human kidney.	Sci Adv	2022
36128490	Profiling Immune Cells in the Kidney Using Tissue Cytometry and Machine Learning.	Kidney360	2022
35406730	Alterations in Protein Translation and Carboxylic Acid Catabolic Processes in Diabetic Kidney Disease.	Cells	2022
36411194	Systemic Effects of Tamm-Horsfall Protein in Kidney Disease.	Seminars in Nephrology	2022
34091721	Human jackstone arms show a protein-rich, X-ray lucent core, suggesting that proteins drive their rapid and linear growth.	Urolithiasis	2022
35309077	Tissue Cytometry With Machine Learning in Kidney: From Small Specimens to Big Data.	Front Physiol	2022
34982521	Cellular and molecular interrogation of kidney biopsy specimens.	Current Opinion in Nephrology and Hypertension	2022
34915736	Stone Morphology Distinguishes Two Pathways of Idiopathic Calcium Oxalate Stone Pathogenesis.	Journal of Endourology	2022
35133089	Label-free imaging of non-deparaffinized sections of the human kidney to determine tissue quality and signatures of disease.	Physiological Reports	2022
34825513	Collagen fibrils and cell nuclei are entrapped within Randall's plaques but not in CaOx matrix overgrowth: A microscopic inquiry into Randall's plaque stone pathogenesis.	Anatomical Record	2022
34658261	VEGFR3 tyrosine kinase inhibition aggravates cisplatin nephrotoxicity.		2021
34017058	Quantitative 3-dimensional imaging and tissue cytometry reveals lymphatic expansion in acute kidney injury.	Laboratory Investigation	2021
33637194	Rationale and design of the Kidney Precision Medicine Project.	Kidney Int	2021
33537765	Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans.	Nephrology Dialysis Transplantation	2021
34169214	Increased Urinary Leukocyte Esterase Distinguishes Patients With Brushite Kidney Stones.	Kidney International Reports	2021
34003797	Integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury.	JCI insight	2021
33568476	Molecular characterization of the human kidney interstitium in health and disease.	Sci Adv	2021
34208140	Pretransplant Serum Uromodulin and Its Association with Delayed Graft Function Following Kidney Transplantation-A Prospective Cohort Study.	Journal of Clinical Medicine	2021
33448928	The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline.	eLife	2021
32769629	Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes.	Transplantation	2021
33252180	In Situ Classification of Cell Types in Human Kidney Tissue Using 3D Nuclear Staining.	Cytometry. Part A : the journal of the International Society for Analytical Cytology	2021
33026465	Multimodal imaging reveals a unique autofluorescence signature of Randall's plaque.	Urolithiasis	2021
33408350	Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline.	Laboratory Investigation	2021
33403824	Demineralization and sectioning of human kidney stones: A molecular investigation revealing the spatial heterogeneity of the stone matrix.	Physiological Reports	2021
33159963	Targeting fibroblast growth factor 23-responsive pathways uncovers controlling genes in kidney mineral metabolism.	Kidney International	2021
30649494	Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis.	Nephrology Dialysis Transplantation	2020
32371628	Hospital-Acquired Versus Community-Acquired Acute Kidney Injury in Patients With Cirrhosis: A Prospective Study.	American Journal of Gastroenterology	2020
32405588	A Precision Medicine Approach Uncovers a Unique Signature of Neutrophils in Patients With Brushite Kidney Stones.	Kidney Int Rep	2020
32336487	Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study.	American Journal of Kidney Diseases	2020
32597856	Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue.	J Vis Exp	2020
32828237	Autosomal dominant tubulointerstitial kidney disease: a new tool to guide genetic testing.	Kidney International	2020
31411505	Admission plasma uromodulin and the risk of acute kidney injury in hospitalized patients with cirrhosis: a pilot study.	Am J Physiol Gastrointest Liver Physiol	2019
31578243	Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel.	Sci Transl Med	2019
31478958	Development and Validation of a Model to Predict Acute Kidney Injury in Hospitalized Patients With Cirrhosis.	Clinical and Translational Gastroenterology	2019
29180395	Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.	Journal of the American Society of Nephrology : JASN	2018
29018138	Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney.	Journal of the American Society of Nephrology : JASN	2018
29870980	Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease.	Nephron	2018
29357410	Tamm-Horsfall protein/uromodulin deficiency elicits tubular compensatory responses leading to hypertension and hyperuricemia.	Am J Physiol Renal Physiol	2018
28154201	Quantitative Three-Dimensional Tissue Cytometry to Study Kidney Tissue and Resident Immune Cells.	Journal of the American Society of Nephrology : JASN	2017