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Author Details

Aaron D Gitler
Stanford University School of Medicine
1999
159
65
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36603548Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein.Neuron2023
37961381FTLD targets brain regions expressing recently evolved genes.medRxiv2023
37577463A molecular atlas of adult <i>C. elegans</i> motor neurons reveals ancient diversity delineated by conserved transcription factor codes.bioRxiv2023
37461476A 3'UTR Insertion Is a Candidate Causal Variant at the <i>TMEM106B</i> Locus Associated with Increased Risk for FTLD-TDP.medRxiv2023
37468412Drugging "undruggable" neurodegenerative disease targets with small molecules.Sci Bull (Beijing)2023
37295429Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.Mol Cell2023
36446586Radiogenomics of <i>C9orf72</i> Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment.J Neurosci2023
36810653Author Correction: Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.Nat Neurosci2023
34654581You come at the misfolded proteins, you best not miss.Trends Biochem Sci2022
35567447Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers.Clin Transl Med2022
35487823Singling out motor neurons in the age of single-cell transcriptomics.Trends Genet2022
35750028APOE told me put my fat in the bag and nobody gets hurt.Cell2022
35588711Why you always in a mood? Pumpin' polyP, actin' brand new.Neuron2022
36400005Rnq1! You are still dangerous, but you can be my wingman anytime.Mol Cell2022
36351406Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics.Cell Rep2022
36163138The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems.Nat Commun2022
36288715Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2.Cell Rep2022
36288714Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2.Cell Rep2022
35052839Phenotypic Heterogeneity among <i>GBA</i> p.R202X Carriers in Lewy Body Spectrum Disorders.Biomedicines2022
35197626TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A.Nature2022
33482083p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).Cell2021
33589834Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons.Nat Neurosci2021
33837088<i>C9orf72</i>-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.Sci Adv2021
34901437Confirming Pathogenicity of the F386L <i>PSEN1</i> Variant in a South Asian Family With Early-Onset Alzheimer Disease.Neurol Genet2021
34647036An optimized ATAC-seq protocol for genome-wide mapping of active regulatory elements in primary mouse cortical neurons.STAR Protoc2021
34616039Neurotoxic reactive astrocytes induce cell death via saturated lipids.Nature2021
34233164A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation.Cell2021
32325033BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.Cell Syst2020
31843624Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.Brain Res2020
31832771Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.Acta Neuropathol2020
33025906A versatile system to record cell-cell interactions.Elife2020
32719333Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model.Nat Commun2020
32853540BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.Cell Syst2020
32814910Neurodegenerative gene's function is not all about those bases.Nature2020
32750315Evolution of a Human-Specific Tandem Repeat Associated with ALS.Am J Hum Genet2020
32302539Just Took a DNA Test, Turns Out 100% Not That Phase.Mol Cell2020
32463448A memory of eS25 loss drives resistance phenotypes.Nucleic Acids Res2020
31110321Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.Nat Neurosci2019
31647889Axons Gonna Ride 'til They Can't No More.Neuron2019
31358992RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats.Nat Neurosci2019
30927072LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.Acta Neuropathol2019
30926670Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties.Proc Natl Acad Sci U S A2019
30982135Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly.Hum Genet2019
30976389Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice.Transl Neurodegener2019
30887850Identification and functional analysis of novel mutations in the <i>SOD1</i> gene in Chinese patients with amyotrophic lateral sclerosis.Amyotroph Lateral Scler Frontotemporal Degener2019
30940688A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS.Genome Res2019
29677512Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.Cell2018
30193092Pour Some Sugar on TDP(-43).Mol Cell2018
29942091Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.Nat Med2018
30129439A matter of balance.Elife2018
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University of Pennsylvania
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Co-authored papers 9
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Co-authored papers 8
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UCSF Weill Institute for Neurosciences, University of California san francisco
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David B Goldstein
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Maria Armakola
Massachusetts General Hospital
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Steven Finkbeiner
J. David Gladstone Institutes
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Richard M Myers
HudsonAlpha Institute for Biotechnology
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Tania F Gendron
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Release 1.2