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Author Details

Yona Levites
Emory University School of Medicine
2001
56
28
PMIDPaper TitleJournal TitlePublished Year
38076912Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease.bioRxiv2023
38027063A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies.Mol Ther Methods Clin Dev2023
35328748Intracerebral but Not Peripheral Infection of Live <i>Porphyromonas gingivalis</i> Exacerbates Alzheimer's Disease Like Amyloid Pathology in APP-TgCRND8 Mice.Int J Mol Sci2022
35352880AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model.EMBO Mol Med2022
35494163Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts.Free Neuropathol2022
33480174Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease.Alzheimers Dement2021
33741985Il-10 signaling reduces survival in mouse models of synucleinopathy.NPJ Parkinsons Dis2021
33508158Biophysical characteristics of lipid-induced Aβ oligomers correlate to distinctive phenotypes in transgenic mice.FASEB J2021
33833060Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.Proc Natl Acad Sci U S A2021
33957936Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.Mol Neurodegener2021
33128896Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes.Mol Ther2021
32252825Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis.Acta Neuropathol Commun2020
33069251Aÿ40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aÿ42 toxicity in Drosophila.Alzheimers Res Ther2020
32665013Fyn depletion ameliorates tau<sup>P301L</sup>-induced neuropathology.Acta Neuropathol Commun2020
32668255Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.Cell Rep2020
32122372Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.Mol Neurodegener2020
31109378Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils.Acta Neuropathol Commun2019
31685865Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus.Sci Rep2019
31472250Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis.Neuroimage2019
31467037An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.J Exp Med2019
30770411rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies.J Exp Med2019
29208777Short Aβ peptides attenuate Aβ42 toxicity in vivo.J Exp Med2018
30261006Designing antibodies against LRRK2-targeted tau epitopes.PLoS One2018
29608591Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.PLoS One2018
28760159Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.Acta Neuropathol Commun2017
28098204Strain-specific Fibril Propagation by an Aβ Dodecamer.Sci Rep2017
27531960Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila.Proc Natl Acad Sci U S A2016
26418152Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis.Hippocampus2016
25228069Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.Mol Ther2015
26253732Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease.Hum Mol Genet2015
26156074IFN-γ promotes Ͽ phosphorylation without affecting mature tangles.FASEB J2015
25904780A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo.J Neurosci2015
25286085Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction.J Vis Exp2014
23347239Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo.Eur J Neurosci2013
24252149Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.Acta Neuropathol Commun2013
23825679Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain.PLoS One2013
23666556Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.Acta Neuropathol2013
22156046Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP.J Alzheimers Dis2012
22910355Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo.Nat Commun2012
22621179Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.Alzheimers Res Ther2012
21073877Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.J Mol Biol2011
19825975Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.FASEB J2010
19275635Quantitative and mechanistic studies of Abeta immunotherapy.CNS Neurol Disord Drug Targets2009
19638957Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.Mol Ther2009
18524908BRI2 (ITM2b) inhibits Abeta deposition in vivo.J Neurosci2008
17611268Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis.J Neurosci2007
16341263Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.J Clin Invest2006
17108166Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.J Neurosci2006
17068112Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.FASEB J2006
16872492Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy.J Neuroinflammation2006
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Collaborators

Todd E Golde
Emory Center for Neurodegenerative Disease
Co-authored papers 41
Paramita Chakrabarty
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 17
Pedro E Cruz
College of Medicine, University of Florida
Co-authored papers 12
Carolina Ceballos-Diaz
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 11
Dennis W Dickson
Mayo Clinic Jacksonville
Co-authored papers 8
Pritam Das
Institute of Medical Sciences, Banaras Hindu University
Co-authored papers 7
Brenda D Moore
College of Medicine, University of Florida
Co-authored papers 7
Christopher Janus
College of Medicine, University of Florida
Co-authored papers 4
Diego E Rincon-Limas
University of Florida
Co-authored papers 4
Cory C Funk
Institute for Systems Biology
Co-authored papers 4
Nil??fer Ertekin-Taner
Mayo Clinic
Co-authored papers 4
Awilda M Rosario
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 4
Eric B Dammer
Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine
Co-authored papers 3
Xue Wang
Mayo Clinic
Co-authored papers 3
Mariet Allen
Mayo Clinic
Co-authored papers 3
Karen N McFarland
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 3
Allan I Levey
Emory University School of Medicine
Co-authored papers 3
Nathan D Price
Institute for Systems Biology
Co-authored papers 3
Edna Grünblatt
Co-authored papers 2
Nadia DiNunno
College of Medicine, Penn State College of Medicine
Co-authored papers 2
Steven G Younkin
Mayo Clinic
Co-authored papers 2
Andrew Li
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 2
Kevin H Strang
College of Medicine, University of Florida
Co-authored papers 2
Minerva M Carrasquillo
Mayo Clinic
Co-authored papers 2
Amanda N Sacino
Johns Hopkins University School of Medicine
Co-authored papers 2
Christophe Verbeeck
Mayo Clinic College of Medicine
Co-authored papers 2
Jungwoo Wren Kim
Institute for Cell Engineering, Johns Hopkins University School of Medicine
Co-authored papers 1
James J Lah
Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine
Co-authored papers 1
David A Bennett
Rush University Medical Center
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Ying-Wooi Wan
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Release 1.2