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Author Details

Jonas Demeulemeester
VIB-KU Leuven Center for Cancer Biology
2010
63
24
PMIDPaper TitleJournal TitlePublished Year
37098241The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia.J Clin Oncol2023
37656621System-wide mapping of peptide-GPCR interactions in C. elegans.Cell Rep2023
37783803Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule.Nat Cancer2023
37609320Single-cell somatic copy number variants in brain using different amplification methods and reference genomes.bioRxiv2023
35145300Biallelic mutations in cancer genomes reveal local mutational determinants.Nat Genet2022
35611992Primary mediastinal large B-cell lymphoma is characterized by large-scale copy-neutral loss of heterozygosity.Genes Chromosomes Cancer2022
35697807Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression.Nat Biotechnol2022
34282324A pan-cancer landscape of somatic mutations in non-unique regions of the human genome.Nat Biotechnol2021
33679782Transcriptional Profiling of STAT1 Gain-of-Function Reveals Common and Mutation-Specific Fingerprints.Front Immunol2021
33832990Interpretation of allele-specific chromatin accessibility using cell state-aware deep learning.Genome Res2021
34874265Analysis of long and short enhancers in melanoma cell states.Elife2021
34824211Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.Nat Commun2021
34822292A ubiquitous disordered protein interaction module orchestrates transcription elongation.Science2021
34143978Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma.Cancer Cell2021
32866294Drivers underpinning the malignant transformation of giant cell tumour of bone.J Pathol2020
32879494Pervasive chromosomal instability and karyotype order in tumour evolution.Nature2020
32870932Correction: LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs.PLoS Pathog2020
32727499Correction to: LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.Retrovirology2020
32727480Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.Retrovirology2020
30692535Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.Nat Commun2019
29329553Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import.Retrovirology2018
29997176Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.Proc Natl Acad Sci U S A2018
29858576Recurrent rearrangements of FOS and FOSB define osteoblastoma.Nat Commun2018
30559362Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.Nat Commun2018
29084774LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.Blood2018
28624199Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy.Mol Ther Nucleic Acids2017
28460266Atom probe tomography analysis of SiGe fins embedded in SiO<sub>2</sub>: Facts and artefacts.Ultramicroscopy2017
29089486Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.Nat Commun2017
27428435LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.EBioMedicine2016
27931250Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing.Genome Biol2016
27788138Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras.PLoS One2016
25809198HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.Retrovirology2015
26245978Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.Nat Commun2015
26293289Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection.Bioessays2015
26346774Mapping interfacial excess in atom probe data.Ultramicroscopy2015
24654558HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.ACS Nano2014
25525795HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort.Cell Host Microbe2014
25063804The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.J Biol Chem2014
25072693BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.Mol Ther Nucleic Acids2014
25082813Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.Cancer Res2014
24915079Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.Acta Crystallogr F Struct Biol Commun2014
24666332LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).Expert Opin Ther Pat2014
24632996Structure, mechanics, and binding mode heterogeneity of LEDGF/p75-DNA nucleoprotein complexes revealed by scanning force microscopy.Nanoscale2014
23318960Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).Leukemia2013
249007184-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.ACS Med Chem Lett2013
24451643Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection.Drug Discov Today Technol2013
24183673The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.Cell Rep2013
23878195Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase.J Biol Chem2013
23721378LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions.Retrovirology2013
235174582-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.ACS Chem Biol2013
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Collaborators

The Francis Crick Institute
Co-authored papers 12
Wellcome Sanger Institute
Co-authored papers 6
Co-authored papers 4
Institute for Cancer Research, Oslo University Hospital
Co-authored papers 4
Manchester Cancer Research Centre, University of Manchester
Co-authored papers 4
Faculty of Clinical Medicine, University of Oslo
Co-authored papers 4
F Hoffmann-La Roche Ltd
Co-authored papers 3
Wellcome Sanger Institute
Co-authored papers 3
ULB-Cancer Research Center (U-CRC), Universite Libre de Bruxelles
Co-authored papers 3
University of Oslo
Co-authored papers 3
University College London, UCL Cancer Institute
Co-authored papers 3
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 3
KU Leuven - University of Leuven
Co-authored papers 3
University College London, UCL Cancer Institute
Co-authored papers 2
Francis Crick Institute
Co-authored papers 2
Royal National Orthopaedic Hospital
Co-authored papers 2
Wellcome Sanger Institute
Co-authored papers 2
KU Leuven Institute for Single Cell Omics (LISCO)
Co-authored papers 2
Universidade de Santiago de Compostela
Co-authored papers 2
Memorial Sloan Kettering Cancer Center
Co-authored papers 1
University of Toronto
Co-authored papers 1
Institute of Microbiology of the CAS
Co-authored papers 1
University of Pennsylvania Perelman School of Medicine
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
University of Basel and University Hospital Basel
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Wellcome Sanger Institute
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The University of Texas MD Anderson Cancer Center
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1