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Author Details

Alexander W Wyatt
University of British Columbia
2007
122
42
PMIDPaper TitleJournal TitlePublished Year
37676819Molecular features of prostate cancer after neoadjuvant therapy in the phase 3 CALGB 90203 trial.J Natl Cancer Inst2024
37980367Phase 1b study of enzalutamide plus CC-115, a dual mTORC1/2 and DNA-PK inhibitor, in men with metastatic castration-resistant prostate cancer (mCRPC).Br J Cancer2024
36914848A generalizable machine learning framework for classifying DNA repair defects using ctDNA exomes.NPJ Precis Oncol2023
37289025The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer.Cancer Res2023
37250326A genome-wide CRISPR screen maps endogenous regulators of PPARG gene expression in bladder cancer.iScience2023
37207301Genetic and Genomic Testing for Prostate Cancer: Beyond DNA Repair.Am Soc Clin Oncol Educ Book2023
37330052Fragmentomic analysis of circulating tumor DNA-targeted cancer panels.Ann Oncol2023
36996325Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer.Clin Cancer Res2023
36437155IBCN Seminar Series 2021: Circulating tumor DNA in bladder cancer.Urol Oncol2023
30528886Molecular tumor heterogeneity in muscle invasive bladder cancer: Biomarkers, subtypes, and implications for therapy.Urol Oncol2022
35507889Genomic Features of Lung-Recurrent Hormone-Sensitive Prostate Cancer.JCO Precis Oncol2022
35859180Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer.Nature2022
35657159Androgen receptor genomic alterations and treatment resistance in metastatic prostate cancer.Prostate2022
35657158Genomic biomarkers to guide precision radiotherapy in prostate cancer.Prostate2022
36439451Towards clinical implementation of circulating tumor DNA in metastatic prostate cancer: Opportunities for integration and pitfalls to interpretation.Front Oncol2022
36001857Long-Term Outcomes and Genetic Predictors of Response to Metastasis-Directed Therapy Versus Observation in Oligometastatic Prostate Cancer: Analysis of STOMP and ORIOLE Trials.J Clin Oncol2022
36309516The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors.Nat Commun2022
36166584TP53 Alterations Are Associated With Poor Survival in Patients With Primary Mediastinal Nonseminoma Germ Cell Tumors.Oncologist2022
36251389The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.Cancer Res2022
35065838Quality and Quantity: Evaluating Tumor Biology Alongside Novel Imaging on Diagnosis of Metastatic Hormone-sensitive Prostate Cancer.Eur Urol2022
34895867Somatic Features of Response and Relapse in Non-muscle-invasive Bladder Cancer Treated with Bacillus Calmette-Guérin Immunotherapy.Eur Urol Oncol2022
34812730Considerations on the identification and management of metastatic prostate cancer patients with DNA repair gene alterations in the Canadian context.Can Urol Assoc J2022
33414135<i>BRCA2</i>, <i>ATM</i>, and <i>CDK12</i> Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression.Clin Cancer Res2021
33769071Olaparib for the treatment of metastatic prostate cancer.Future Oncol2021
33742188Building confidence in circulating tumour DNA assays for metastatic castration-resistant prostate cancer.Nat Rev Urol2021
33836265Cabazitaxel versus abiraterone or enzalutamide in poor prognosis metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase II trial.Ann Oncol2021
33808193Increased Pathway Complexity Is a Prognostic Biomarker in Metastatic Castration-Resistant Prostate Cancer.Cancers (Basel)2021
33690902Differential treatment outcomes in BRCA1/2-, CDK12-, and ATM-mutated metastatic castration-resistant prostate cancer.Cancer2021
33658587Cell-free DNA concentration and fragment size as a biomarker for prostate cancer.Sci Rep2021
33630412Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer.J Pathol Clin Res2021
34804843A marrow-minded look at immune checkpoint blockade resistance in metastatic castration resistant prostate cancer.Transl Androl Urol2021
34801437Tissue- and Blood-derived Genomic Biomarkers for Metastatic Hormone-sensitive Prostate Cancer: A Systematic Review.Eur Urol Oncol2021
34219051Technical and biological constraints on ctDNA-based genotyping.Trends Cancer2021
34171218The evolving role of germline genetic testing and management in prostate cancer: Report from the Princess Margaret Cancer Centre international retreat.Can Urol Assoc J2021
34197212Prospective Evaluation of Clinical Outcomes Using a Multiplex Liquid Biopsy Targeting Diverse Resistance Mechanisms in Metastatic Prostate Cancer.J Clin Oncol2021
34112710Blood Biomarker Landscape in Patients with High-risk Nonmetastatic Castration-Resistant Prostate Cancer Treated with Apalutamide and Androgen-Deprivation Therapy as They Progress to Metastatic Disease.Clin Cancer Res2021
34258232Development of secondary urothelial carcinoma following complete response to immune checkpoint inhibitors.Urol Case Rep2021
34083234Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition.Clin Cancer Res2021
33373705Prostate Cancer Foundation Hormone-Sensitive Prostate Cancer Biomarker Working Group Meeting Summary.Urology2021
33452452Clinical implications of genomic alterations in metastatic prostate cancer.Prostate Cancer Prostatic Dis2021
33422353Quantitative and Qualitative Analysis of Blood-based Liquid Biopsies to Inform Clinical Decision-making in Prostate Cancer.Eur Urol2021
33420073Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer.Nat Commun2021
32451180Activating AKT1 and PIK3CA Mutations in Metastatic Castration-Resistant Prostate Cancer.Eur Urol2020
31640893Clinical Outcomes in Cyclin-dependent Kinase 12 Mutant Advanced Prostate Cancer.Eur Urol2020
32046920Plasma Circulating Tumor DNA and Clonal Hematopoiesis in Metastatic Renal Cell Carcinoma.Clin Genitourin Cancer2020
31744831Identification of Hypermutation and Defective Mismatch Repair in ctDNA from Metastatic Prostate Cancer.Clin Cancer Res2020
32574722HSD3B1 (1245A&gt;C) germline variant and clinical outcomes in metastatic castration-resistant prostate cancer patients treated with abiraterone and enzalutamide: results from two prospective studies.Ann Oncol2020
32847979Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer.Mol Cancer Ther2020
32724107Evaluating the quantity, quality and size distribution of cell-free DNA by multiplex droplet digital PCR.Sci Rep2020
32218990Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer.NPJ Genom Med2020
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Collaborators

University of British Columbia
Co-authored papers 43
University of British Columbia
Co-authored papers 36
University of British Columbia
Co-authored papers 35
University of British Columbia
Co-authored papers 29
University of British Columbia
Co-authored papers 21
UCSF Medical Center-Mount Zion
Co-authored papers 19
University of British Columbia
Co-authored papers 16
University of British Columbia
Co-authored papers 15
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
Co-authored papers 15
University of California san francisco
Co-authored papers 13
Prostate Cancer Research Center, Tampere University and Tays Cancer Center
Co-authored papers 13
University of British Columbia
Co-authored papers 13
University of British Columbia
Co-authored papers 13
Oxford Brookes University
Co-authored papers 11
University of California San Francisco
Co-authored papers 11
Prostate Cancer Research Center, Tampere University and Tays Cancer Center
Co-authored papers 10
University of British Columbia
Co-authored papers 10
Fujian Medical University Cancer Hospital and Fujian Cancer Hospital
Co-authored papers 10
Dana-Farber Cancer Institute
Co-authored papers 10
University of British Columbia
Co-authored papers 10
University of British Columbia
Co-authored papers 9
University of British Columbia
Co-authored papers 8
University of California-San Francisco
Co-authored papers 8
University of British Columbia
Co-authored papers 8
University of British Columbia
Co-authored papers 8
UF Health Cancer Center
Co-authored papers 7
Ghent University, GZA Ziekenhuizen
Co-authored papers 7
OHSU Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 7
University of British Columbia
Co-authored papers 7
Peter MacCallum Cancer Centre
Co-authored papers 7