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Author Details

William F DeGrado
Department of Pharmaceutical Chemistry, University of California san francisco
1982
452
99
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36927157EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.Proc Natl Acad Sci U S A2023
37632140Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface.Protein Sci2023
37961414Docking for molecules that bind in a symmetric stack with SymDOCK.bioRxiv2023
38014268<i>De novo</i> Design of Peptides that Bind Specific Conformers of α-Synuclein.bioRxiv2023
37425793Patterning and folding of intestinal villi by active mesenchymal dewetting.bioRxiv2023
37308712Transient water wires mediate selective proton transport in designed channel proteins.Nat Chem2023
37236970Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.Nat Commun2023
36399277Aβ and Tau Prions Causing Alzheimer's Disease.Methods Mol Biol2023
36778268EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.bioRxiv2023
36824741Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology.bioRxiv2023
34985907Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior.J Am Chem Soc2022
35756531Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides.Chem Sci2022
35811759De novo metalloprotein design.Nat Rev Chem2022
35655098Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.Nat Struct Mol Biol2022
36219675SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers.Biochemistry2022
35320345The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.J Exp Med2022
35082148Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.Proc Natl Acad Sci U S A2022
35080027Brilacidin, a COVID-19 drug candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell.J Med Virol2022
33373215<i>De Novo</i> Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species.J Am Chem Soc2021
33635059Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site.J Am Chem Soc2021
33723045Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA.Proc Natl Acad Sci U S A2021
34908093Theoretical and experimental comparisons of simple peptide-membrane systems; towards defining the reaction space: general discussion.Faraday Discuss2021
34904568Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ.Elife2021
34961556Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome.Acta Neuropathol Commun2021
34693965Spiers Memorial Lecture: Analysis and <i>de novo</i> design of membrane-interactive peptides.Faraday Discuss2021
34570183Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction.Blood Adv2021
34155106Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors.Proc Natl Acad Sci U S A2021
34010565Visualization of Platelet Integrins via Two-Photon Microscopy Using Anti-transmembrane Domain Peptides Containing a Blue Fluorescent Amino Acid.Biochemistry2021
33983722Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy.J Am Chem Soc2021
34342217Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity.Biochemistry2021
33956668Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.J Clin Invest2021
33972753Constructing ion channels from water-soluble α-helical barrels.Nat Chem2021
32152544Deep mutational scanning reveals the structural basis for α-synuclein activity.Nat Chem Biol2020
31894969X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.Biochemistry2020
32041676<i>De novo</i> protein design, a retrospective.Q Rev Biophys2020
33301681Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates.J Am Chem Soc2020
33318174Allosteric cooperation in a de novo-designed two-domain protein.Proc Natl Acad Sci U S A2020
33007395Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.Bioorg Med Chem Lett2020
32883865A defined structural unit enables de novo design of small-molecule-binding proteins.Science2020
32933245Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics.J Am Chem Soc2020
32786289Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.ACS Chem Biol2020
32949533Prion biology: implications for Alzheimer's disease therapeutics.Lancet Neurol2020
30694671Exposing the Nucleation Site in α-Helix Folding: A Joint Experimental and Simulation Study.J Phys Chem B2019
31640988A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion.J Biol Chem2019
31854299De novo design of a homo-trimeric amantadine-binding protein.Elife2019
31358628In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments.Proc Natl Acad Sci U S A2019
31184871X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case.J Am Chem Soc2019
31264850Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts.Biochemistry2019
31264413Proton-Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel.J Am Chem Soc2019
307440044-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics.Molecules2019
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Collaborators

Hyunil Jo
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 35
Jeffery G Saven
University of Pennsylvania
Co-authored papers 11
Haifan Wu
Wichita State University
Co-authored papers 11
David Eisenberg
university of california los angeles
Co-authored papers 11
Thomas Lemmin
Co-authored papers 11
Carlo Condello
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 10
Cinque Soto
Co-authored papers 10
Stanley B Prusiner
Weill Institute for Neurosciences, University of California San Francisco
Co-authored papers 8
Kathleen S Molnar
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 7
Jan St??hr
Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 7
Huong T Kratochvil
Department of Pharmaceutical Chemistry, University of California-San Francisco
Co-authored papers 7
Gregory A Voth
Co-authored papers 6
John W Weisel
University of Pennsylvania
Co-authored papers 6
Aparna Sundaram
Formerly with the Guttmacher Institute.
Co-authored papers 4
Matteo Dal Peraro
Institute of Bioengineering
Co-authored papers 4
Mark Goulian
University of Pennsylvania
Co-authored papers 4
Alison M Maxwell
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 4
Shalom D Goldberg
Janssen Pharmaceuticals
Co-authored papers 4
Luigi Di Costanzo
University of Naples Federico II
Co-authored papers 4
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 3
James S Fraser
University of California san francisco
Co-authored papers 3
Duilio Cascio
Co-authored papers 3
Ivaylo Ivanov
Georgia State University, GA 30302 USA Center for Diagnostics and Therapeutics
Co-authored papers 3
Graham D Clinthorne
University of Pennsylvania
Co-authored papers 3
David Baker
University of Washington
Co-authored papers 3
Kurt Giles
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Abby Oehler
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 2
Gabriel Gonzalez
Harbor university of california los angeles Medical Center
Co-authored papers 2
Daniel L Minor
Cardiovascular Research Institute, University of California san francisco
Co-authored papers 2
Gregory E Merz
University of California san francisco
Co-authored papers 2
Release 1.2