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Author Details

Richard C Boucher
1977
513
124
PMIDPaper TitleJournal TitlePublished Year
37349353Development of a novel air-liquid interface airway tissue equivalent model for in vitro respiratory modeling studies.Sci Rep2023
36342131Prolonged, physiologically relevant nicotine concentrations in the airways of smokers.American Journal of Physiology - Lung Cellular and Molecular Physiology2023
38016030Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non-Cystic Fibrosis Bronchiectasis (NCFB).2023
37695863Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators.2023
37217548A blood and bronchoalveolar lavage protein signature of rapid FEV<sub>1</sub> decline in smoking-associated COPD.Sci Rep2023
37285404Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.2023
36965846Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection.J Theor Biol2023
37399831Associations of COVID-19 symptoms with omicron subvariants BA.2 and BA.5, host status, and clinical outcomes in Japan: a registry-based observational study.2023
36563691An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2.Cell Host Microbe2023
36798223Associations of COVID-19 Symptoms with Omicron Subvariants BA.2 and BA.5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan.2023
34697091Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier.Thorax2022
35512490The clinical impact of maternal COVID-19 on mothers, their infants, and placentas with an analysis of vertical transfer of maternal SARS-CoV-2-specific IgG antibodies.Placenta2022
36166305Immunogenetics associated with severe coccidioidomycosis.JCI Insight2022
35816430Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease.Am J Respir Crit Care Med2022
35437233Mucus and mucus flake composition and abundance reflect inflammatory and infection status in cystic fibrosis.Journal of Cystic Fibrosis2022
35378080Modeling insights into SARS-CoV-2 respiratory tract infections prior to immune protection.Biophys J2022
35879412Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.Nat Genet2022
35486871Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence.American Journal of Respiratory Cell and Molecular Biology2022
35363522Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis.Science advances2022
35677067A Multitrait Locus Regulates Sarbecovirus Pathogenesis.bioRxiv2022
35862771A Multitrait Locus Regulates Sarbecovirus Pathogenesis.mBio2022
35857635SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice.Sci Transl Med2022
35355018Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.Nature2022
35353667SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13.Proc Natl Acad Sci U S A2022
34801592Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD.Chest2022
35040594Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial.Int Forum Allergy Rhinol2022
35239513Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.Journal of Clinical Investigation2022
35217407Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications.eBioMedicine2022
35194605A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies.bioRxiv2022
35001665Physiology and pathophysiology of human airway mucus.Physiological Reviews2022
35074895Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein.Proc Natl Acad Sci U S A2022
35221375Molecular Dynamics Simulations to Explore the Structure and Rheological Properties of Normal and Hyperconcentrated Airway Mucus.Studies in Applied Mathematics2021
34013253Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections.Res Sq2021
34058148Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.Lancet Respiratory Medicine,The2021
33788673Reuse of Cell Culture Inserts for Human Primary Airway Epithelial Cell Studies.American Journal of Respiratory Cell and Molecular Biology2021
34109248Acute and durable effect of inhaled hypertonic saline on mucociliary clearance in adult asthma.ERJ Open Res2021
33358825Purinergic receptors in airway hydration.Biochemical Pharmacology2021
33232302Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene.JCI Insight2021
33321047Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.American Journal of Respiratory and Critical Care Medicine2021
32946266FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms.American Journal of Respiratory Cell and Molecular Biology2020
31855577Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.JCI insight2020
31800264Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.American Journal of Physiology - Lung Cellular and Molecular Physiology2020
32298651Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis.Cell2020
32084371Phenotypic Characterization and Comparison of Cystic Fibrosis Rat Models Generated Using CRISPR/Cas9 Gene Editing.American Journal of Pathology2020
32817334The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.Journal of Immunology2020
33140061Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis.medRxiv2020
32526206SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.Cell2020
33031744A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.Cell2020
32802823Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis.ERJ Open Research2020
33184236SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.Science2020
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