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Author Details

Alexei A Podtelezhnikov
Genetics and Pharmacogenomics, Merck & Co., Inc.
1994
34
17
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35404422A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.Toxicol Sci2022
33549674Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells.J Biotechnol2021
32559289Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.Toxicol Sci2020
32119089Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities.Toxicol Sci2020
32409700Author Correction: The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.Sci Rep2020
32559301Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.Toxicol Sci2020
31127949AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats.Toxicol Sci2019
29848382Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis.Fluids Barriers CNS2018
29222421The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.Sci Rep2017
28419375Transcriptional Profiling of Cholinergic Neurons From Basal Forebrain Identifies Changes in Expression of Genes Between Sleep and Wake.Sleep2017
27050123Toxicogenomics in drug development: a match made in heaven?Expert Opin Drug Metab Toxicol2016
26587671Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys: Differentiation From Alendronate.J Bone Miner Res2016
27216421Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.Mol Neurodegener2016
26955841Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA).J Biol Rhythms2016
26765077An accessible pharmacodynamic transcriptional biomarker for notch target engagement.Clin Pharmacol Ther2016
27112350Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain.Mol Neurodegener2016
25197809Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation.Sleep2014
23622250Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.Cell2013
22547604Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors.J Clin Oncol2012
22445337Transcriptional architecture of the primate neocortex.Neuron2012
21054384Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.J Neurochem2011
22216330Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging.PLoS One2011
19486664Reconstruction and stability of secondary structure elements in the context of protein structure prediction.Biophys J2009
18624565Comment on "Efficient Monte Carlo trial moves for polypeptide simulations" [J. Chem. Phys. 123, 174905 (2005)].J Chem Phys2008
18577227CRANKITE: A fast polypeptide backbone conformation sampler.Source Code Biol Med2008
17109405Learning about protein hydrogen bonding by minimizing contrastive divergence.Proteins2007
17048397Bayesian segmental models with multiple sequence alignment profiles for protein secondary structure and contact map prediction.IEEE/ACM Trans Comput Biol Bioinform2006
16049911Exhaustive Metropolis Monte Carlo sampling and analysis of polyalanine conformations adopted under the influence of hydrogen bonds.Proteins2005
12579583Modeling HIV-1 integrase complexes based on their hydrodynamic properties.Biopolymers2003
11248029Mechanism of topology simplification by type II DNA topoisomerases.Proc Natl Acad Sci U S A2001
11053141Multimerization-cyclization of DNA fragments as a method of conformational analysis.Biophys J2000
10512709Large-scale effects of transcriptional DNA supercoiling in vivo.J Mol Biol1999
10557257Equilibrium distributions of topological states in circular DNA: interplay of supercoiling and knotting.Proc Natl Acad Sci U S A1999
7850350Testing the quality of electron microscope mapping data for DNA molecules with sequence-specific ligands.Micron1994
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Collaborators

Andrey Loboda
Merck & Co., Inc.
Co-authored papers 8
David S Knopman
Mayo Clinic Rochester
Co-authored papers 2
Ruo-Pan Huang
Raybiotech Co.
Co-authored papers 2
Ronald C Petersen
Mayo Clinic Rochester
Co-authored papers 2
Rachelle Abbey
Stanford University School of Medicine
Co-authored papers 2
Steven G Younkin
Mayo Clinic
Co-authored papers 2
Matan Hofree
Broad Institute of Harvard and MIT
Co-authored papers 2
Chung-Huan J Sun
University of California san francisco
Co-authored papers 2
Ramya Narasimhan
Stanford University School of Medicine
Co-authored papers 2
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 2
Adam L Boxer
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Allan I Pack
University of Pennsylvania Perelman School of Medicine
Co-authored papers 2
Hudson Johns
Stanford University School of Medicine
Co-authored papers 2
Tony Wyss-Coray
Stanford University
Co-authored papers 2
Suraj Pradhan
Stanford University
Co-authored papers 2
Bruce L Miller
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Kurt M Lucin
Eastern Connecticut State University
Co-authored papers 2
Badri N Vardarajan
Columbia University Irving Medical Center, New York Presbyterian Hospital
Co-authored papers 2
Rosa Rademakers
University of Antwerp
Co-authored papers 2
Markus Britschgi
Roche Pharma Research and Early Development
Co-authored papers 2
Ruochun Huang
RayBiotech Inc., USA RayBiotech Inc.
Co-authored papers 2
NiCole A Finch
Mayo Clinic
Co-authored papers 2
Philipp A Jaeger
University of California
Co-authored papers 2
Eliezer Masliah
National Institute On Aging
Co-authored papers 2
Anna Karydas
Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Bradley F Boeve
Mayo Clinic Rochester
Co-authored papers 2
Elizabeth Head
University of California Irvine
Co-authored papers 2
Neill R Graff-Radford
Mayo Clinic Florida
Co-authored papers 2
Lindsay A Farrer
Boston University Chobanian & Avedisian School of Medicine
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Release 1.2