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Author Details

Mason W Freeman
Center for Computational and Integrative Biology, Massachusetts General Hospital
1980
109
52
PMIDPaper TitleJournal TitlePublished Year
36266539Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers.Hypertens Res2023
37409573Bexagliflozin as an adjunct to metformin for the treatment of type 2 diabetes in adults: A 24-week, randomized, double-blind, placebo-controlled trial.Diabetes Obes Metab2023
36790596Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects.Am J Cardiovasc Drugs2023
36342143Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension.N Engl J Med2023
36178197A 96-week, double-blind, randomized controlled trial comparing bexagliflozin to glimepiride as an adjunct to metformin for the treatment of type 2 diabetes in adults.Diabetes Obes Metab2023
35285245Correction for Jeyaseelan et al., "Distinct Roles of Pattern Recognition Receptors CD14 and Toll-Like Receptor 4 in Acute Lung Injury".Infect Immun2022
34367681An overview of the process, progress, and outcomes of a National Center for Accelerated Innovation: The Boston Biomedical Innovation Center Experience.J Clin Transl Sci2021
31749238A 12-week, randomized, double-blind, placebo-controlled, four-arm dose-finding phase 2 study evaluating bexagliflozin as monotherapy for adults with type 2 diabetes.Diabetes Obes Metab2020
31161692A 24-week, randomized, double-blind, active-controlled clinical trial comparing bexagliflozin with sitagliptin as an adjunct to metformin for the treatment of type 2 diabetes in adults.Diabetes Obes Metab2019
31644864Case 22-2019: A 65-Year-Old Woman with Myopathy. Reply.N Engl J Med2019
31297965A 96-week, multinational, randomized, double-blind, parallel-group, clinical trial evaluating the safety and effectiveness of bexagliflozin as a monotherapy for adults with type 2 diabetes.Diabetes Obes Metab2019
31314973Case 22-2019: A 65-Year-Old Woman with Weakness, Dark Urine, and Dysphagia.N Engl J Med2019
31101403Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD.Am J Kidney Dis2019
29767459Long-term effects of patiromer for hyperkalaemia treatment in patients with mild heart failure and diabetic nephropathy on angiotensin-converting enzymes/angiotensin receptor blockers: results from AMETHYST-DN.ESC Heart Fail2018
28775338NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges.Nat Rev Drug Discov2017
28267733US immigration order strikes against biotech.Nat Biotechnol2017
25632026Exome sequencing in suspected monogenic dyslipidemias.Circ Cardiovasc Genet2015
26376130Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia.Kidney Int2015
26172895Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial.JAMA2015
25882488Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.Circulation2015
24293640Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.J Lipid Res2014
25734176High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection.Open Forum Infect Dis2014
22116191The Creating an Optimal Warfarin Nomogram (CROWN) Study.Thromb Haemost2012
23012897Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis.Ann Otol Rhinol Laryngol2012
21441830The path from bench to bedside: considerations before starting the journey.J Investig Med2011
22097147Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.Ann Otol Rhinol Laryngol2011
21860089Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-β production independent of cholesterol efflux activity.J Alzheimers Dis2011
18948635Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.Arterioscler Thromb Vasc Biol2009
18484747SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.Biochemistry2008
19430537Targeting Innate Immunity for CV Benefit.Drug Discov Today Ther Strateg2008
18957418ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.J Biol Chem2008
17142808ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.J Lipid Res2007
17303779Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects.Arterioscler Thromb Vasc Biol2007
17196452Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol.Am J Cardiol2007
16449790Statins, cholesterol, and the prevention of coronary heart disease.FASEB J2006
16728653Scavenger receptors in atherosclerosis: beyond lipid uptake.Arterioscler Thromb Vasc Biol2006
16823376A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies.Nat Biotechnol2006
15731076Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.Infect Immun2005
30795382Spatial Analysis of Almond Leaf Scorch Disease in the San Joaquin Valley of California: Factors Affecting Pathogen Distribution and Spread.Plant Dis2005
16646848Generalized rank tests for replicated microarray data.Stat Appl Genet Mol Biol2005
16192269Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.J Biol Chem2005
16043658Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.Circulation2005
16078385Nonparametric methods for microarray data based on exchangeability and borrowed power.J Biopharm Stat2005
16026120Atherosclerosis and innate immune signaling.Ann Med2005
16075060Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice.J Clin Invest2005
15550377Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.J Biol Chem2005
15781429Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia.Eur Heart J2005
14617740ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.J Lipid Res2004
15567863Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis.Science2004
15367722The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.Physiol Genomics2004
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Collaborators

Co-authored papers 22
Co-authored papers 3
Center for Computational and Integrative Biology, Massachusetts General Hospital
Co-authored papers 3
Co-authored papers 2
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Broad Institute of MIT and Harvard
Co-authored papers 2
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University of Virginia
Co-authored papers 2
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Broad Institute
Co-authored papers 1
Beth Israel Deaconess Medical Center
Co-authored papers 1
Stanford University
Co-authored papers 1
Novo Nordisk Research Centre
Co-authored papers 1
Inc., Lehigh University
Co-authored papers 1
Howard Hughes Medical Institute, Princeton University
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
Washington University School of Medicine
Co-authored papers 1
Simons Center for Systems Biology, Institute for Advanced Study
Co-authored papers 1
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
Co-authored papers 1
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1
university of california san diego School of Medicine
Co-authored papers 1
University of Washington
Co-authored papers 1
Co-authored papers 1
ALS Therapy Development Institute
Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1
Center for Bioinformatics, University of Oslo
Co-authored papers 1