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Author Details

Debra Dunaway-Mariano
University of New Mexico
1978
176
41
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
32786412Structural Analysis of Binding Determinants of <i>Salmonella typhimurium</i> Trehalose-6-phosphate Phosphatase Using Ground-State Complexes.Biochemistry2020
32972137Proteomic Profiles of Thyroid Gland and Gene Expression of the Hypothalamic-Pituitary-Thyroid Axis Are Modulated by Exposure to AgNPs during Prepubertal Rat Stages.Chem Res Toxicol2020
29695157Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions.Biochemistry2018
29952545Mechanism of Substrate Recognition and Catalysis of the Haloalkanoic Acid Dehalogenase Family Member α-Phosphoglucomutase.Biochemistry2018
28741300Catalytic Mechanism of the Hotdog-Fold Thioesterase PA1618 Revealed by X-ray Structure Determination of a Substrate-Bound Oxygen Ester Analogue Complex.Chembiochem2017
28192710Rational design of reversible inhibitors for trehalose 6-phosphate phosphatases.Eur J Med Chem2017
27526404Catalytic scaffolds for phosphoryl group transfer.Curr Opin Struct Biol2016
25848029Panoramic view of a superfamily of phosphatases through substrate profiling.Proc Natl Acad Sci U S A2015
24577717Structure-guided approach for detecting large domain inserts in protein sequences as illustrated using the haloacid dehalogenase superfamily.Proteins2014
25210039Enzyme promiscuity: engine of evolutionary innovation.J Biol Chem2014
25010423Structure and catalysis in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.Biochemistry2014
24992697Divergence of substrate specificity and function in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.Biochemistry2014
24992307Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs.PLoS Pathog2014
23094589Design, synthesis, and evaluation of inhibitors of pyruvate phosphate dikinase.J Org Chem2013
24308306W. W. "Mo" Cleland: a catalytic life.Biochemistry2013
23851007Co-evolution of HAD phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins BF1314 and PG1653.FEBS Lett2013
23848398Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis.Biochemistry2013
23992466Effects of alkoxy groups on arene rings of lignin β-O-4 model compounds on the efficiencies of single electron transfer-promoted photochemical and enzymatic C-C Bond Cleavage Reactions.J Org Chem2013
23989152Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase.Acta Crystallogr Sect F Struct Biol Cryst Commun2013
23959887Consequences of domain insertion on sequence-structure divergence in a superfold.Proc Natl Acad Sci U S A2013
22347769A Thioester Substrate Binds to the Enzyme Arthrobacter Thioesterase in Two Ionization States; Evidence from Raman Difference Spectroscopy.J Raman Spectrosc2012
22873756The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU.Biochemistry2012
22871024Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.Biochemistry2012
22897136Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function.Biochemistry2012
22208697Investigation of the catalytic mechanism of the hotdog-fold enzyme superfamily Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase.Biochemistry2012
21413788Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.Biochemistry2011
21999478The Enzyme Function Initiative.Biochemistry2011
21989931The X-ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: comparison of paralogous functions in B. thetaiotaomicron.Proteins2011
21894910Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase.Biochemistry2011
21384857Regioselectivity of enzymatic and photochemical single electron transfer promoted carbon-carbon bond fragmentation reactions of tetrameric lignin model compounds.J Org Chem2011
21366328Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase.Biochemistry2011
21333622Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase.J Inorg Biochem2011
20050615Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).Biochemistry2010
20831160Nature and kinetic analysis of carbon-carbon bond fragmentation reactions of cation radicals derived from SET-oxidation of lignin model compounds.J Org Chem2010
20383005X-ray structure and characterization of carbamate kinase from the human parasite Giardia lamblia.Acta Crystallogr Sect F Struct Biol Cryst Commun2010
20050614Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB) .Biochemistry2010
18986982Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members.J Biol Chem2009
19889535Markers of fitness in a successful enzyme superfamily.Curr Opin Struct Biol2009
19635449Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry.Anal Biochem2009
19640561Mechanisms of catalysis and inhibition operative in the arginine deiminase from the human pathogen Giardia lamblia.Bioorg Chem2009
19453107The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family.Biochemistry2009
19507245X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasite Giardia lamblia.Proteins2009
19119850In vitro kinetic analysis of substrate specificity in enterobactin biosynthetic lower pathway enzymes provides insight into the biochemical function of the hot dog-fold thioesterase EntH.Biochemistry2009
19170545The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis.Biochemistry2009
19133276Structure and function of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily member.J Mol Biol2009
19154134Analysis of the structural determinants underlying discrimination between substrate and solvent in beta-phosphoglucomutase catalysis.Biochemistry2009
19236002Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase.Biochemistry2009
19320426The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase.Biochemistry2009
17654544The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function.Proteins2008
18804026Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).Chem Biol2008
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Collaborators

Karen N Allen
Boston University
Co-authored papers 46
Patricia C Babbitt
University of California san francisco
Co-authored papers 7
Chetanya Pandya
Icahn School of Medicine at Mount Sinai
Co-authored papers 5
Marc C Morais
University of Texas Medical Branch
Co-authored papers 4
Steven C Almo
Albert Einstein College of Medicine
Co-authored papers 4
Ezra Peisach
The State University of New Jersey
Co-authored papers 4
Yu Xia
College of Information Engineering, Zhejiang University of Technology
Co-authored papers 2
Yury Patskovsky
New York University Grossman School of Medicine
Co-authored papers 2
Frank M Raushel
Texas A&M University, College Station
Co-authored papers 2
Alexander Maxwell Burroughs
National Center for Biotechnology Information, National Institutes of Health
Co-authored papers 2
Barry L Wanner
Harvard Medical School
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Daniel J Saltzberg
University of California san francisco
Co-authored papers 1
Jonathan V Sweedler
University of Illinois at Urbana-Champaign
Co-authored papers 1
C. Dale Poulter
University of Utah
Co-authored papers 1
Ronald D Seidel
Albert Einstein College of Medicine
Co-authored papers 1
Heidi J Imker
Harvard Medical School
Co-authored papers 1
Vladimir N Malashkevich
Albert Einstein College of Medicine
Co-authored papers 1
John E Cronan
University of Illinois
Co-authored papers 1
Rafael Toro
Medical College of Wisconsin
Co-authored papers 1
Jeremy D Selengut
Craig Venter Institute, 9704 Medical Center Drive
Co-authored papers 1
J Michael Sauder
Eli Lilly and Co.
Co-authored papers 1
Katherine H O'Toole
Boston University
Co-authored papers 1
Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Richard N Armstrong
The Hospital for Sick Children
Co-authored papers 1
Brandan Hillerich
Cue BioPharma Inc.
Co-authored papers 1
Shoshana D Brown
University of California san francisco
Co-authored papers 1
John A Buglino
Sloan Kettering Institute
Co-authored papers 1
Matthew P Jacobson
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Randy J Read
Cambridge Institute for Medical Research, University of Cambridge
Co-authored papers 1
Release 1.2